Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H10N2O |
| Molecular Weight | 210.2313 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(=CN=C1)C#CC2=NC=CC=C2
InChI
InChIKey=VRTFKUFTEWQHDD-UHFFFAOYSA-N
InChI=1S/C13H10N2O/c1-16-13-8-11(9-14-10-13)5-6-12-4-2-3-7-15-12/h2-4,7-10H,1H3
| Molecular Formula | C13H10N2O |
| Molecular Weight | 210.2313 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/12877935
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/12877935
Methoxy-PEPy is a selective ligand for the Metabotropic Glutamate Subtype 5 (mGlu5) Receptor. [3H]Methoxy-PEPy is used as a radiolabel to study mGlu5 R distribution and binding with other agents.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). | 2003-07-18 |
|
| [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. | 2003-02-10 |
Patents
Sample Use Guides
For in vivo mGlu5 receptor occupancy study [3H]Methoxy-PEPy was administered to rats and mice intravenously at 50 microCi/kg.
Route of Administration:
Intravenous
The functional potency of compounds in vitro was assessed using an automated assay employing Ltk-cells stably expressing human recombinant mGlu5 receptors. This cell-based assay measures changes in cytosolic Ca2+ concentrations ([Ca2+]i) by fluorescence detection using the Ca2+-sensitive dye fura-2. Methoxy-PEPy is antagonist of mGlu5 receptor with IC50 of 1nM.
| Substance Class |
Chemical
Created
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admin
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Edited
Wed Apr 02 09:16:05 GMT 2025
by
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on
Wed Apr 02 09:16:05 GMT 2025
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0868W4SS6C
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| Record Status |
Validated (UNII)
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524924-76-3
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0868W4SS6C
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