ARTICAINE ACID

Details

Stereochemistry	RACEMIC
Molecular Formula	C12H18N2O3S
Molecular Weight	270.348
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCNC(C)C(=O)NC1=C(SC=C1C)C(O)=O

InChI

InChIKey=LUPKINKNYDFRIB-UHFFFAOYSA-N

InChI=1S/C12H18N2O3S/c1-4-5-13-8(3)11(15)14-9-7(2)6-18-10(9)12(16)17/h6,8,13H,4-5H2,1-3H3,(H,14,15)(H,16,17)

HIDE SMILES / InChI

Molecular Formula	C12H18N2O3S
Molecular Weight	270.348
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15966499

Articaine, a dental local anesthetic, is metabolized into articaine acid. The last is excreted as such or further transforms into the glucuronidated metabolite.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
UDP-glucuronosyltransferase 2 Target ID: UDP-glucuronosyltransferase Sources: https://www.ncbi.nlm.nih.gov/pubmed/15966499	Substrate 661

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Pharmacokinetics, metabolism, and renal excretion of articaine and its metabolite articainic acid in patients after epidural administration.	1989 Jan	2714265
A simple method for the determination of articaine and its metabolite articainic acid in dentistry: application to a comparison of articaine and lidocaine concentrations in alveolus blood.	1993 Oct	8309318
Clinical pharmacology and the use of articaine for local and regional anaesthesia.	2005 Jun	15966499

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:33:33 GMT 2023` Edited by `admin` on `Fri Dec 15 15:33:33 GMT 2023`
Record UNII	99R4WP7QC7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ARTICAINE ACID

Common Name

English

2-THIOPHENECARBOXYLIC ACID, 4-METHYL-3-((1-OXO-2-(PROPYLAMINO)PROPYL)AMINO)-

Common Name

English

ARTICAINIC ACID

Common Name

English

ARTICAINE RELATED COMPOUND B

Common Name

English

ARTICAINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

4-METHYL-3-(((2RS)-2-(PROPYLAMINO)PROPANOYL)AMINO)THIOPHENE-2-CARBOXYLIC ACID

Systematic Name

English

ARTICAINE RELATED COMPOUND B [USP-RS]

Common Name

English

Code System Code Type Description

PUBCHEM

163921