ARTICAINE ACID

Details

Stereochemistry	RACEMIC
Molecular Formula	C12H18N2O3S
Molecular Weight	270.348
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCNC(C)C(=O)NC1=C(SC=C1C)C(O)=O

InChI

InChIKey=LUPKINKNYDFRIB-UHFFFAOYSA-N

InChI=1S/C12H18N2O3S/c1-4-5-13-8(3)11(15)14-9-7(2)6-18-10(9)12(16)17/h6,8,13H,4-5H2,1-3H3,(H,14,15)(H,16,17)

HIDE SMILES / InChI

Molecular Formula	C12H18N2O3S
Molecular Weight	270.348
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15966499

Articaine, a dental local anesthetic, is metabolized into articaine acid. The last is excreted as such or further transforms into the glucuronidated metabolite.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
UDP-glucuronosyltransferase 2 Target ID: UDP-glucuronosyltransferase Sources: https://www.ncbi.nlm.nih.gov/pubmed/15966499	Substrate 661

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Clinical pharmacology and the use of articaine for local and regional anaesthesia.	2005-06	15966499
A simple method for the determination of articaine and its metabolite articainic acid in dentistry: application to a comparison of articaine and lidocaine concentrations in alveolus blood.	1993-10	8309318
Pharmacokinetics, metabolism, and renal excretion of articaine and its metabolite articainic acid in patients after epidural administration.	1989-01	2714265

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:01:07 GMT 2025` Edited by `admin` on `Mon Mar 31 18:01:07 GMT 2025`
Record UNII	99R4WP7QC7
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ARTICAINE RELATED COMPOUND B

Preferred Name

English

ARTICAINE ACID

Common Name

English

2-THIOPHENECARBOXYLIC ACID, 4-METHYL-3-((1-OXO-2-(PROPYLAMINO)PROPYL)AMINO)-

Common Name

English

ARTICAINIC ACID

Common Name

English

ARTICAINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

4-METHYL-3-(((2RS)-2-(PROPYLAMINO)PROPANOYL)AMINO)THIOPHENE-2-CARBOXYLIC ACID

Systematic Name

English

ARTICAINE RELATED COMPOUND B [USP-RS]

Common Name

English

Code System Code Type Description

PUBCHEM

163921