Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Nalmefene is the first medication approved for alcoholism
with the primary goal of reducing alcohol intake in an as
needed approach. Nalmefene
received a marketing authorization valid throughout the
European Union on February 25, 2013 and is under de...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Dexoxadrol is a sigma receptor agonist. Dexoxadrol, the D-isomer of dioxodrol, which produces PCP-like behavioural effects and displaces bound [3H]PCP, was a potent blocker of the PCP-sensitive, voltage-gated K+ channel. Dexoxadrol was developed as ...
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
DOV-102,677 is a “Triple” Monoamine Neurotransmitter Uptake Inhibitor being developed by Merck for treating the major depressive disorder. In preclinical studies, DOV 102,677 increased extracellular levels of DA and 5-HT in the prefrontal cortex at 1...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I, with IC50 values of 7.7 and 14 nM respectively, and >30 selectivity relative to 42 other kinases tested. Casein kinase Iε phosphorylates PER proteins, which are involv...
Status:
Other
Class (Stereo):
CHEMICAL (EPIMERIC)
Targets:
Conditions:
BIIE-0246 is a highly potent, high affinity antagonist selective for the Y2 receptor subtype. BIIE-0246 is a drug used in scientific research, it was one of the first non-peptide Y2-selective antagonists developed, and remains among the most widely ...
Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
SB-206606 (better known as BRL-37344) was developed by Beecham Pharmaceuticals and is currently licensable from GlaxoSmithKline. SB-206606 is an agonist for the Beta-3 adrenergic receptor with an EC 50 value of 17 nM (human B3AR expressed in CHO cell...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Norharman or beta-carboline (9H-pyrido[3,4-b]indole) is a neuroactive alkaloid first isolated from Peganum harmala L. It is implicated in a number of human diseases including Parkinson's disease, tremor, addiction and cancer. Norharman formed endogen...
Class (Stereo):
CHEMICAL (ACHIRAL)
Picamilon (also known as N-nicotinoyl-GABA, Pycamilon, and Pikamilon) is a drug formed by a synthetic combination of niacin and GABA. It was developed in the Soviet Union in 1969 and further studied in both Russia and Japan as a prodrug of GABA. Pica...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Lithium orotate consists of lithium, an alkali metal, and orotic acid, a compound produced naturally in the body. Lithium orotate is marketed as a dietary supplement. It has a “GRAS” status. The chronic administration of lithium helps to support heal...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Nitrefazole (2-methyl-4-nitro-1-(4-nitro-phenyl)imidazole, Altimol) is a strong and long lasting inhibitor of aldehyde dehydrogenase, an enzyme involved in the metabolism of alcohol. It was used for the treatment of alcoholism as an alcohol-sensitizi...