Stereochemistry | ACHIRAL |
Molecular Formula | C11H8N2 |
Molecular Weight | 168.1946 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
N1C2=CC=CC=C2C3=C1C=NC=C3
InChI
InChIKey=AIFRHYZBTHREPW-UHFFFAOYSA-N
InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
Norharman or beta-carboline (9H-pyrido[3,4-b]indole) is a neuroactive alkaloid first isolated from Peganum harmala L. It is implicated in a number of human diseases including Parkinson's disease, tremor, addiction and cancer. Norharman formed endogenously but external sources have been identified (among others fried meat and fish, meat extracts, alcoholic drinks, coffee brews, tobacco smoke). It inhibits monoamine oxidase and indoleamine 2,3-dioxygenase. In addition norharman binds with high affinity to imidazoline I2B receptors. Plasma norharman levels are elevated in chronic alcoholics and Parkinson's disease patients.
CNS Activity
Approval Year
PubMed
Sample Use Guides
Pharmacokinetics of oral norharman in healthy subjects: 7, 65 and 110 microg/kg.
Rats: 0.2-20 mg/kg, i.p.
Mice: 2.5-10 mg/kg, i.p.
Route of Administration:
Other