Details
Stereochemistry | RACEMIC |
Molecular Formula | C19H22ClNO4 |
Molecular Weight | 363.835 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H](CC1=CC=C(OCC(O)=O)C=C1)NC[C@H](O)C2=CC(Cl)=CC=C2
InChI
InChIKey=ZGGNJJJYUVRADP-ACJLOTCBSA-N
InChI=1S/C19H22ClNO4/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24)/t13-,18+/m1/s1
Molecular Formula | C19H22ClNO4 |
Molecular Weight | 363.835 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/15684518 | https://www.rndsystems.com/products/brl-37344-sodium-salt_0948 | https://www.ncbi.nlm.nih.gov/pubmed/23955701 | https://www.ncbi.nlm.nih.gov/pubmed/25462854 | https://www.ncbi.nlm.nih.gov/pubmed/1345889 |https://www.ncbi.nlm.nih.gov/pubmed/23890664 | http://adisinsight.springer.com/drugs/800006890 | https://www.ncbi.nlm.nih.gov/pubmed/12237641 | https://www.ncbi.nlm.nih.gov/pubmed/8773403 | https://www.ncbi.nlm.nih.gov/pubmed/20930473
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15684518 | https://www.rndsystems.com/products/brl-37344-sodium-salt_0948 | https://www.ncbi.nlm.nih.gov/pubmed/23955701 | https://www.ncbi.nlm.nih.gov/pubmed/25462854 | https://www.ncbi.nlm.nih.gov/pubmed/1345889 |https://www.ncbi.nlm.nih.gov/pubmed/23890664 | http://adisinsight.springer.com/drugs/800006890 | https://www.ncbi.nlm.nih.gov/pubmed/12237641 | https://www.ncbi.nlm.nih.gov/pubmed/8773403 | https://www.ncbi.nlm.nih.gov/pubmed/20930473
BRL-37344 is a selective β3-adrenergic receptor agonist originated by GlaxoSmithKline. Ki value is 287 nM for β3 receptor, 1750 nM for β1 receptor and 1120 nM for β2 receptor. BRL-37344 can decrease nerve-evoked contractions in human detrusor smooth muscle isolated strips, it can also stimulate fuel oxidation by soleus muscle in vitro. In fasted rabbits, BRL-37344 significantly increased plasma nonesterified fatty acids (NEFA) levels through β3-adrenoceptor. However, BRL-37344 had no effect on plasma glucose levels. In mice, BRL-37344 increased circulating transaminase levels through activation of β3-adrenoceptor. BRL-37344 increases glucose transport into L6 myocytes through a mechanism different from that of insulin. But preclinical for Diabetes mellitus was discontinued.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23955701https://www.ncbi.nlm.nih.gov/pubmed/20164362
Curator's Comment: BRL-37344 is systemically active and crosses the blood-brain barrier
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
430.0 nM [Ki] | |||
Target ID: P13945 Gene ID: 155.0 Gene Symbol: ADRB3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15684518 |
17.0 nM [EC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Adrenergic stimulation of lipoprotein lipase gene expression in rat brown adipocytes differentiated in culture: mediation via beta3- and alpha1-adrenergic receptors. | 1997 Feb 1 |
|
Enhancement of memory consolidation in chicks by beta(3)-adrenoceptor agonists. | 2001 Feb 16 |
|
Beta2-adrenoceptor-mediated inhibition of field stimulation induced contractile responses of the smooth muscle of the rat prostate gland. | 2001 Nov 9 |
|
Metabolic markers following beta-adrenoceptor agonist infusion in footshock-stressed rats. | 2001 Sep |
|
Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. | 2004 Feb |
|
The effects and selectivity of beta-adrenoceptor agonists in rat myometrium and urinary bladder. | 2007 Nov 14 |
|
Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and beta2-adrenoceptor mechanisms. | 2008 Oct |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25462854
Curator's Comment: In mice BRL-37344 has also being used i.p. https://www.ncbi.nlm.nih.gov/pubmed/20930473
The effect of SB-206606 on the liver uptake of Brown Adipose Tissue in the Liver (BAT/L) was examined in mice. Obese mice and mice with Diabetes Mellitus (DM) received an intraperitoneal injection of SB-206606 (2.5 mg/kg) three times per week for two weeks. After two weeks of treatment with SB-206606, there was a significant increase in BAT/L for both obese mice (6.64±1.97) and DM mice (5.25±1.50) compared with the controls without SB-206606 treatment (4.20±1.13 in obese control mice, P = 0.010; 2.32±1.01 in DM control mice, P = 0.004). In normal control mice, even a single-dose of SB-206606 would significantly increase BAT/L compared with the untreated controls (31.74±21.39 versus 7.61±1.44, P = 0.002).
Route of Administration:
Intraperitoneal
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15684518
Human B3-AR cDNA was cloned from total RNA extracted from human neuroblastoma cell SK-N-MC (ATCC HTB 10), and inserted into a pKCN1 plasmid, which was subsequently transformed into Chinese Hamster Ovary Cell line (CHO-K1). B3-AR agonistic activity was assessed by measurement of cAMP accumulation level in CHO cells expressing human b3-AR. Cells were treated with varying concentrations of SB-206606 and the EC50 value was determined as the concentration required to achieve 50% of cAMP accumulation. BRL 37344 exhibited agonistic activity with EC50 17 nM.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:05:16 UTC 2023
by
admin
on
Sat Dec 16 08:05:16 UTC 2023
|
Record UNII |
5DZZ1926YW
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
BRL-37344
Created by
admin on Sat Dec 16 08:05:16 UTC 2023 , Edited by admin on Sat Dec 16 08:05:16 UTC 2023
|
PRIMARY | |||
|
5DZZ1926YW
Created by
admin on Sat Dec 16 08:05:16 UTC 2023 , Edited by admin on Sat Dec 16 08:05:16 UTC 2023
|
PRIMARY | |||
|
DTXSID20921329
Created by
admin on Sat Dec 16 08:05:16 UTC 2023 , Edited by admin on Sat Dec 16 08:05:16 UTC 2023
|
PRIMARY | |||
|
9841972
Created by
admin on Sat Dec 16 08:05:16 UTC 2023 , Edited by admin on Sat Dec 16 08:05:16 UTC 2023
|
PRIMARY | |||
|
114333-71-0
Created by
admin on Sat Dec 16 08:05:16 UTC 2023 , Edited by admin on Sat Dec 16 08:05:16 UTC 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |