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Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Verazide, which is related to Isoniazid has
been developed in Australia for the treatment of pulmonary tuberculosis. It is equally effective as Isoniazid and less toxic.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Lexipafant is a platelet-activating factor (PAF) antagonist. It was hypothesized that the substance could beneficially affect the cognitive performance of HIV infected people. Lexipafant was as tolerable as placebo. At week 6 and week 10 after baseline evaluations, the lexipafant group showed trends toward improvement on the Rey Auditory Verbal Learning test as well as the timed gait test. A phase IIa placebo-controlled study reported that lexipafant was not effective in patients with severe ulcerative colitis receiving corticosteroids. Two lexipafant treated patient had adverse events: severe influenza-like symptoms in one and hypotension with iliac artery thrombosis in one. The clinical trials of lexipafant in the treatment of acute pancreatitis were undertaken with considerable optimism. There was a significant reduction in the incidence of organ failure and in total organ failure score at the end of medication (72 h).
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Ilonidap, a tenidap derivative agent possesses an anti-inflammatory properties.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Bemoradan (RWJ-22867), a potent positive inotropic agent, inhibits cardiac phosphodiesterase fraction III. This compound was developed for the management of congestive heart failure. However, the information about the nowadays study of bemoradan is not available.
Class (Stereo):
CHEMICAL (ACHIRAL)
Tribuzone is a non-steroidal anti-inflammatory drug (NSAID) that has been used to treat gout and Gilbert's syndrome. The usual adverse effects of NSAIDs have been observed with tribuzone, namely gastric effects, fluid retention and headache. Like other 3-oxoalkyl substituted diphenyldioxopyrazolidines it inhibits platelet aggregation.
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Trifezolac is an ibufenac derivative. It is an analgesic, antipyretic, anti-inflammatory agent.
Status:
Investigational
Source:
INN:triclodazol [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Triclodazol is a tranquilizer.
Status:
Investigational
Source:
Physiol Res. Nov 2019;68(Suppl 1):S65-S74.: Not Applicable Human clinical trial Completed Low Back Pain
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Trimecaine is an amide series local anesthetic with antiarrhythmic activity. It was shown to be capable of eliminating the flutter of atria in dogs simulated by an electric stimulation of the myocardium and atrial fibrillation in cats induced with aconitin and precludes ventricular fibrillation in rats arising due to intoxication with calcium chloride. Trimecaine noticeably mitigates the toxic effect of strophanthin. While depressing the automatism of the sinoatrial node the drug does not affect the conduction function. The combination of epidural trimecaine with morphine after a major urological surgery provides a superior analgesia with fewer side effects when compared to epidurally delivered bupivacaine with fentanyl.
Class (Stereo):
CHEMICAL (ACHIRAL)
Trifosmin is used for the preparation of 99mTc-labeled myocardial perfusion imaging agents.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Trizoxime is an antidepressant.