TRIBUZONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H24N2O3
Molecular Weight	364.4376
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)C(=O)CCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=OFVFGKQCUDMLLP-UHFFFAOYSA-N

InChI=1S/C22H24N2O3/c1-22(2,3)19(25)15-14-18-20(26)23(16-10-6-4-7-11-16)24(21(18)27)17-12-8-5-9-13-17/h4-13,18H,14-15H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C22H24N2O3
Molecular Weight	364.4376
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7192607 | Aronson, J.K. (2015) Meyler's Side Effects of Drugs, page 136, retrieved from: https://books.google.ca/books?id=NOKoBAAAQBAJ | Aronson, J.K. (2014) Meyler's Side Effects of Drugs 15E, retrieved from: https://books.google.ca/books?id=tqsXzG1W8HgC

Tribuzone is a non-steroidal anti-inflammatory drug (NSAID) that has been used to treat gout and Gilbert's syndrome. The usual adverse effects of NSAIDs have been observed with tribuzone, namely gastric effects, fluid retention and headache. Like other 3-oxoalkyl substituted diphenyldioxopyrazolidines it inhibits platelet aggregation.

Approval Year

PubMed

Title	Date	PubMed
Determination of some non-steroid anti-inflammatory drugs by capillary isotachophoresis.	1995-08	8573641
[Uricosuria after administration of benethazone].	1985	4095639
[Use of benetazon in gout therapy].	1981-10-01	7199218
[The effect of adjuvant arthritis on the tribuzone levels in the blood of rats].	1981-03	7195318
[Pharmacokinetics of tribuzone (Benetazone Spofa) in patients with Gilbert's syndrome (author's transl)].	1980-10	7192607
The effect of azathioprine, hydrocortisone and trimethazone on the occurrence of active lymphocytes in liver of endotoxin treated rabbits.	1979-12	398656
[Interactions of benetazon with modified starches. II. An increase in the solubility of benetazon in water by interactions with modified starches].	1979-09	575315
[Interaction of benetazon with modified starches. I. Changes in the separation coefficient of benetazon in the hexane:water system by interaction with modified starches].	1979-07	575073
Pyrazolidine derivatives: a comparative study of their effects on platelet aggregation.	1979	94876
[Biotransformation of tribuzone in vitro].	1976-02	945132

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:14:29 GMT 2025` Edited by `admin` on `Mon Mar 31 18:14:29 GMT 2025`
Record UNII	DUU9GVA746
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRIBUZONE

Official Name

English

BENETAZON

Preferred Name

English

tribuzone [INN]

Common Name

English

Tribuzone [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257