TRIMECAINE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H24N2O
Molecular Weight	248.3639
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CC(=O)NC1=C(C)C=C(C)C=C1C

InChI

InChIKey=GOZBHBFUQHMKQB-UHFFFAOYSA-N

InChI=1S/C15H24N2O/c1-6-17(7-2)10-14(18)16-15-12(4)8-11(3)9-13(15)5/h8-9H,6-7,10H2,1-5H3,(H,16,18)

HIDE SMILES / InChI

Molecular Formula	C15H24N2O
Molecular Weight	248.3639
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1027568 | https://www.ncbi.nlm.nih.gov/pubmed/18517133 | Morton, I.K., Hall, J.M. (2012) Concise Dictionary of Pharmacological Agents, page 281, retrieved from: https://books.google.ru/books?id=tsjrCAAAQBAJ

Trimecaine is an amide series local anesthetic with antiarrhythmic activity. It was shown to be capable of eliminating the flutter of atria in dogs simulated by an electric stimulation of the myocardium and atrial fibrillation in cats induced with aconitin and precludes ventricular fibrillation in rats arising due to intoxication with calcium chloride. Trimecaine noticeably mitigates the toxic effect of strophanthin. While depressing the automatism of the sinoatrial node the drug does not affect the conduction function. The combination of epidural trimecaine with morphine after a major urological surgery provides a superior analgesia with fewer side effects when compared to epidurally delivered bupivacaine with fentanyl.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
hydrogen transport 2 Target ID: GO:0006818 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2553153	Inhibitor 8504

PubMed

Title	Date	PubMed
[Detection of certain local anesthetics in biological fluids by chemo-toxicological analysis].	2009-07-03	19569536
Convergence of nasal and tracheal neural pathways in modulating the cough response in guinea pigs.	2009-06	19617651
Prenatal diagnosis and management of fetal Long QT syndrome.	2009-02	18709401
The epidural postoperative analgesia after a major urological procedures--a comparison of trimecaine and morphine to bupivacaine and fentanyl.	2008	18517133
Local administration of 2% trimecaine affects the content of fucosylated glycoconjugates in goblet cells in rabbit tracheal epithelium.	2006-08	16875493
Membrane mechanisms of antiarrhythmic effect of quaternidine.	2005-06	16224582
[Effect of polymer concentration on rheological properties of Carbopol 980 hydrogels containing trimecainium chloride].	2005-03	15895974
[Effect of trimecaine derivatives and lidocaine on hemodynamics].	2004-06-11	15188755
[Study of antiarrhythmic activity and duration of action of quaternidine].	2003-12-03	14650209
[The antiarrhythmic activity of the trimecain ammonium derivative in myocardial ischemia].	2003-08-20	12924229
[Disarticulation of the knee joint].	2003	12807042
[Infiltration of local anesthetics into the thyroid gland capsule for surgery and the postoperative period].	2002-10	12564092
[Laboratory and clinical study of therapeutic efficacy of medicinal films for surgical procedures].	2002-09-14	12227104
[Magnetically-guided anesthetics based on highly dispersed iron powders coated by polyacrylamide].	2002-04-24	11969173
[A rare complication of conduction anesthesia in the treatment of finger injury].	2002	12528622
[Some aspects of epidural anesthesia in patients with chronic renal insufficiency].	2001-11-06	11692688
The effect of local administration of 2% trimecaine on the glycoconjugate content of goblet cells in the rabbit tracheal epithelium.	2001	12092112
[Pathogenesis of hemodynamic disorders during treatment of cardiac arrythmias in heart surgery patients with obsidan, trimecaine and lidocaine].	1984-09-01	6083737
[Comparative study of the activity of anti-arrhythmia agents in calcium chloride-induced arrhythmia in mice].	1983-05-01	6861988
[Complications after intravenous administration of anti-arrhythmia agents].	1982-11	7154501
[Antiarrhythmic activity of trimecaine in experimental arrhythmia and its effect on the heart conduction system].	1976-06-01	1027568

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:14:28 GMT 2025` Edited by `admin` on `Mon Mar 31 18:14:28 GMT 2025`
Record UNII	IN1233R0JO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRIMECAINE [MI]

Preferred Name

English

TRIMECAINE

Official Name

English

Trimecaine [WHO-DD]

Common Name

English

trimecaine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C245