BEMORADAN

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H13N3O3
Molecular Weight	259.2606
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1CC(=O)NN=C1C2=CC3=C(NC(=O)CO3)C=C2

InChI

InChIKey=XZPGINPFWXLYNW-UHFFFAOYSA-N

InChI=1S/C13H13N3O3/c1-7-4-11(17)15-16-13(7)8-2-3-9-10(5-8)19-6-12(18)14-9/h2-3,5,7H,4,6H2,1H3,(H,14,18)(H,15,17)

HIDE SMILES / InChI

Molecular Formula	C13H13N3O3
Molecular Weight	259.2606
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2153210

Bemoradan (RWJ-22867), a potent positive inotropic agent, inhibits cardiac phosphodiesterase fraction III. This compound was developed for the management of congestive heart failure. However, the information about the nowadays study of bemoradan is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Heteroatom analogues of bemoradan: chemistry and cardiotonic activity of 1,4-benzothiazinylpyridazinones.	1992 Jan	1732525
Simultaneous monitoring of bemoradan pharmacokinetics and hemodynamics in mongrel dogs.	1992 Oct	1489944
Pharmacokinetics and bioavailability of bemoradan, a long-acting inodilator in healthy males.	1994 Feb	8004360
Evaluation of the excretion, and metabolism of the cardiotonic agent bemoradan in male rats and female beagle dogs.	2001 Oct-Dec	11808869

Patents

Sample Use Guides

In Vivo Use Guide

bemoradan HCL salt in capsules. 0.5, 1, 1.5 and 2 mg of bemoradan

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:57:25 GMT 2023` Edited by `admin` on `Fri Dec 15 15:57:25 GMT 2023`
Record UNII	G2S2V1ETBQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BEMORADAN

Official Name

English

7-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-2H-1,4-benzoxazin-3(4H)-one

Systematic Name

English

2H-1,4-BENZOXAZIN-3(4H)-ONE, 7-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)-

Systematic Name

English

ORF 22867

Code

English

BEMORADAN [USAN]

Common Name

English

bemoradan [INN]

Common Name

English

ORF-22867

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C744