Details
Stereochemistry | ACHIRAL |
Molecular Formula | C2H5NO2 |
Molecular Weight | 75.0666 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NCC(O)=O
InChI
InChIKey=DHMQDGOQFOQNFH-UHFFFAOYSA-N
InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
Molecular Formula | C2H5NO2 |
Molecular Weight | 75.0666 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Glycine (Cly) is a natural amino acid neurotransmitter that acts as a co-agonist at Glutamate [NMDA] receptors in the brain and is an activator of glycine receptors, GLRA1-3, GLRB. The abnormal Gly levels have been implicated in neuropsychiatric disorders. Alterations in Gly levels are implicated in several diseases of the central nervous system. Glycine was studied in phase II of clinical trials in patients with schizophrenia. The results have shown that using of glycine was associated with reduced symptoms with promising effect sizes and a possibility of improvement in cognitive function. Besides, glycine was also studied in clinical trials phase II in children with cystic fibrosis. The clinical, spirometric and inflammatory status of subjects with cystic fibrosis improved after just 8 weeks of glycine intake, suggesting that this amino acid might constitute a novel therapeutic tool for these patients. In addition, Gly was proposed as a biomarker for brain tumor malignancy. Glycine is a component of a nutrients mixture for peripheral administration to well-nourished mildly catabolic adult patients who require only short-term parenteral nutrition.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1262868
Curator's Comment: Known to be CNS non-penetrant in rabbit. Human data not available.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2094124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28828606 |
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Target ID: CHEMBL5845 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17154252 |
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Target ID: CHEMBL5871 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17154252 |
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Target ID: CHEMBL1075092 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28514141 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Diagnostic | Unknown Approved UseUnknown |
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Palliative | Unknown Approved UseUnknown |
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Palliative | Unknown Approved UseUnknown |
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Preventing | FREAMINE III 8.5% Approved UseAminosyn, Sulfite-Free, (a crystalline amino acid solution) infused with dextrose by peripheral vein infusion is indicated as a source of nitrogen in the nutritional support of patients with adequate stores of body fat, in whom, for short periods of time, oral nutrition cannot be tolerated, is undesirable, or inadequate. SUPPLEMENTAL ELECTROLYTES, IN ACCORDANCE WITH THE PRESCRIPTION OF THE ATTENDING PHYSICIAN, MUST BE ADDED TO AMINOSYN SOLUTIONS WITHOUT ELECTROLYTES. Aminosyn can be administered peripherally with dilute (5 to 10%) dextrose solution and I.V. fat emulsion as a source of nutritional support. This form of nutritional support can help to preserve protein and reduce catabolism in stress conditions where oral intake is inadequate. When administered with concentrated dextrose solutions with or without fat emulsions, Aminosyn is also indicated for central vein infusion to prevent or reverse negative nitrogen balance in patients where: (a) the alimentary tract, by the oral, gastrostomy or jejunostomy route cannot or should not be used; (b) gastrointestinal absorption of protein is impaired; (c) metabolic requirements for protein are substantially increased as with extensive burns and (d) morbidity and mortality may be reduced by replacing amino acids lost from tissue breakdown, thereby preserving tissue reserves, as in acute renal failure. Launch Date1971 |
PubMed
Title | Date | PubMed |
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Differences in phosphorylation of human and chicken stathmin by MAP kinase. | 2001 |
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The effect of amino acid spacers on the antigenicity of dimeric peptide--inducing cross-reacting antibodies to a cell surface protein antigen of Streptococcus mutans. | 2001 Feb |
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The folate cycle and disease in humans. | 2001 Feb |
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Functional projection distances of spinal interneurons mediating reciprocal inhibition during swimming in Xenopus tadpoles. | 2001 Feb |
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Distribution of transcripts for the brain-specific GDP/GTP exchange factor collybistin in the developing mouse brain. | 2001 Feb |
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Biosynthesis of threonine from homoserine by mixed rumen microorganisms: an in vitro study. | 2001 Feb |
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Trimethylamine oxide counteracts effects of hydrostatic pressure on proteins of deep-sea teleosts. | 2001 Feb 15 |
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Isolation of a new melanoma antigen, MART-2, containing a mutated epitope recognized by autologous tumor-infiltrating T lymphocytes. | 2001 Feb 15 |
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vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma. | 2001 Feb 2 |
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Ligand-independent dimerization and activation of the oncogenic Xmrk receptor by two mutations in the extracellular domain. | 2001 Feb 2 |
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DNA recognition by the methyl-CpG binding domain of MeCP2. | 2001 Feb 2 |
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Amino acid residues outside of the pore region contribute to N-type calcium channel permeation. | 2001 Feb 23 |
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Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure. | 2001 Feb 6 |
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Critical role of the residue size at position 87 in H2O2- dependent substrate hydroxylation activity and H2O2 inactivation of cytochrome P450BM-3. | 2001 Feb 9 |
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Ehlers-Danlos syndrome type IV with a unique point mutation in COL3A1 and familial phenotype of myocardial infarction without organic coronary stenosis. | 2001 Jan |
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A missense mutation encoding cys(67) --> gly in neurophysin ii is associated with early onset autosomal dominant neurohypophyseal diabetes insipidus. | 2001 Jan |
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Determination of bile acids in biological fluids by liquid chromatography-electrospray tandem mass spectrometry. | 2001 Jan |
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Slow dorsal-ventral rhythm generator in the lamprey spinal cord. | 2001 Jan |
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Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse. | 2001 Jan |
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Neither GABA(A) nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane. | 2001 Jan |
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Ethanol potentiation of glycine-induced responses in dissociated neurons of rat ventral tegmental area. | 2001 Jan |
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A high resolution (1)H magic angle spinning NMR study of a high-M(r) subunit of wheat glutenin. | 2001 Jan |
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Selective activation of group I metabotropic glutamate receptors upregulates preprodynorphin, substance P, and preproenkephalin mRNA expression in rat dorsal striatum. | 2001 Jan |
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Analysis of glycoconjugate patterns of normal and hormone-induced dysplastic Noble rat prostates, and an androgen-independent Noble rat prostate tumor, by lectin histochemistry and protein blotting. | 2001 Jan 1 |
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Crystal structure of soybean proglycinin A1aB1b homotrimer. | 2001 Jan 12 |
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Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor. | 2001 Jan 15 |
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Intracellular folding pathway of the cystine knot-containing glycoprotein hormone alpha-subunit. | 2001 Jan 16 |
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Flavonoid 6-hydroxylase from soybean (Glycine max L.), a novel plant P-450 monooxygenase. | 2001 Jan 19 |
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The function of Arg-94 in the oxidation and decarboxylation of glutaryl-CoA by human glutaryl-CoA dehydrogenase. | 2001 Jan 5 |
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Genetics, an alternative way to discover, characterize and understand ion channels. | 2001 Jan-Feb |
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Computed free energy differences between point mutations in a collagen-like peptide. | 2001 Mar |
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(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. | 2001 Mar |
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Pet111p, an inner membrane-bound translational activator that limits expression of the Saccharomyces cerevisiae mitochondrial gene COX2. | 2001 Mar 2 |
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Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid. | 2001 Mar 30 |
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Amino acid residue penultimate to the amino-terminal gly residue strongly affects two cotranslational protein modifications, N-myristoylation and N-acetylation. | 2001 Mar 30 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29246256
Daily oral supplement of glycine at a dose of 0.5 g/kg divided in three doses during 8 weeks
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15388434
The excess of glycine inhibits the growth of many bacteria, and it is used as a nonspecific antiseptic agent due to its low level of toxicity in animals. The MIC at which 90% of strains are inhibited for glycine was almost 2.5 mg/ml for 31 strains of H. pylori, including CLR-resistant strains.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:14:33 GMT 2023
by
admin
on
Fri Dec 15 15:14:33 GMT 2023
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Record UNII |
TE7660XO1C
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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LOINC |
25922-6
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CFR |
21 CFR 520.1060
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2389-5
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2390-3
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GLYCINE
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LOINC |
13750-5
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CFR |
21 CFR 172.320
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LOINC |
47635-8
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56681-0
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WHO-ATC |
B05CX03
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47636-6
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15135-7
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32244-6
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2392-9
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47639-0
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CFR |
21 CFR 170.50
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LOINC |
22650-6
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13397-5
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30066-5
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47634-1
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26929-0
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26807-8
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27325-0
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32245-3
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47637-4
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LOINC |
25921-8
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CFR |
21 CFR 310.532
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admin on Fri Dec 15 15:14:33 GMT 2023 , Edited by admin on Fri Dec 15 15:14:33 GMT 2023
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CFR |
21 CFR 582.5049
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LOINC |
47633-3
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LOINC |
55862-7
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CFR |
21 CFR 331.11
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LOINC |
22709-0
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DSLD |
177 (Number of products:5)
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LOINC |
15143-1
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2391-1
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2393-7
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DSLD |
92 (Number of products:1270)
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LOINC |
22718-1
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CFR |
21 CFR 331.15
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WHO-VATC |
QB05CX03
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CFR |
21 CFR 172.812
Created by
admin on Fri Dec 15 15:14:33 GMT 2023 , Edited by admin on Fri Dec 15 15:14:33 GMT 2023
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SUB12000MIG
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TE7660XO1C
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |
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SALT/SOLVATE -> PARENT |
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |
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SALT/SOLVATE -> PARENT | |||
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TARGET -> INHIBITOR |
Binding assay
IC50
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |
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SALT/SOLVATE -> PARENT |
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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TARGET -> INHIBITOR |
IC50
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Related Record | Type | Details | ||
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PRODRUG -> METABOLITE ACTIVE |
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Related Record | Type | Details | ||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
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