MILACEMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H16N2O
Molecular Weight	144.2147
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCNCC(N)=O

InChI

InChIKey=GJNNXIYZWIZFRH-UHFFFAOYSA-N

InChI=1S/C7H16N2O/c1-2-3-4-5-9-6-7(8)10/h9H,2-6H2,1H3,(H2,8,10)

HIDE SMILES / InChI

Molecular Formula	C7H16N2O
Molecular Weight	144.2147
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1634705 | https://www.ncbi.nlm.nih.gov/pubmed/2769256 | https://adisinsight.springer.com/drugs/800001228 | https://www.ncbi.nlm.nih.gov/pubmed/3516669

Milacemide, a prodrug for glycine, is an inhibitor of the B form of monoamine oxidase. This drug could enhance dopaminergic activity in the brain and could be used as therapy for Parkinson's disease. Milacemide participated in clinical trials as a treatment for senile dementia of the Alzheimer type (SDAT). However, results have shown the drug was not an effective treatment in enhancing cognition in SDAT patients. In addition, milacemide has been tested for antiepileptic efficacy; however, this study was discontinued.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome.	2007-07	17659477
[New therapeutic options in Alzheimer's disease].	2006-04-21	16625510
Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat.	1998-07	9755023
Milacemide therapy for Parkinson's disease.	1993	8380487
The novel neuropsychotropic agent milacemide is a specific enzyme-activated inhibitor of brain monoamine oxidase B.	1989-10	2769256

Sample Use Guides

In Vivo Use Guide

1200 mg/day milacemide treatment for 1 month (113 patients received milacemide, and 115 patients received placebo

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:57:48 GMT 2025` Edited by `admin` on `Mon Mar 31 17:57:48 GMT 2025`
Record UNII	0HXT24RECU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

milacemide [INN]

Preferred Name

English

MILACEMIDE

Official Name

English

2-(PENTYLAMINO)ACETAMIDE

Systematic Name

English

ACETAMIDE, 2-(PENTYLAMINO)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C264