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Details

Stereochemistry ACHIRAL
Molecular Formula C7H16N2O
Molecular Weight 144.2147
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MILACEMIDE

SMILES

CCCCCNCC(N)=O

InChI

InChIKey=GJNNXIYZWIZFRH-UHFFFAOYSA-N
InChI=1S/C7H16N2O/c1-2-3-4-5-9-6-7(8)10/h9H,2-6H2,1H3,(H2,8,10)

HIDE SMILES / InChI

Molecular Formula C7H16N2O
Molecular Weight 144.2147
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Milacemide, a prodrug for glycine, is an inhibitor of the B form of monoamine oxidase. This drug could enhance dopaminergic activity in the brain and could be used as therapy for Parkinson's disease. Milacemide participated in clinical trials as a treatment for senile dementia of the Alzheimer type (SDAT). However, results have shown the drug was not an effective treatment in enhancing cognition in SDAT patients. In addition, milacemide has been tested for antiepileptic efficacy; however, this study was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed

Sample Use Guides

1200 mg/day milacemide treatment for 1 month (113 patients received milacemide, and 115 patients received placebo
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:26:27 GMT 2023
Edited
by admin
on Fri Dec 15 15:26:27 GMT 2023
Record UNII
0HXT24RECU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MILACEMIDE
INN  
INN  
Official Name English
2-(PENTYLAMINO)ACETAMIDE
Systematic Name English
milacemide [INN]
Common Name English
ACETAMIDE, 2-(PENTYLAMINO)-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C264
Created by admin on Fri Dec 15 15:26:27 GMT 2023 , Edited by admin on Fri Dec 15 15:26:27 GMT 2023
Code System Code Type Description
MESH
C039332
Created by admin on Fri Dec 15 15:26:27 GMT 2023 , Edited by admin on Fri Dec 15 15:26:27 GMT 2023
PRIMARY
EVMPD
SUB08960MIG
Created by admin on Fri Dec 15 15:26:27 GMT 2023 , Edited by admin on Fri Dec 15 15:26:27 GMT 2023
PRIMARY
CAS
76990-56-2
Created by admin on Fri Dec 15 15:26:27 GMT 2023 , Edited by admin on Fri Dec 15 15:26:27 GMT 2023
PRIMARY
INN
5266
Created by admin on Fri Dec 15 15:26:27 GMT 2023 , Edited by admin on Fri Dec 15 15:26:27 GMT 2023
PRIMARY
NCI_THESAURUS
C81467
Created by admin on Fri Dec 15 15:26:27 GMT 2023 , Edited by admin on Fri Dec 15 15:26:27 GMT 2023
PRIMARY
SMS_ID
100000080631
Created by admin on Fri Dec 15 15:26:27 GMT 2023 , Edited by admin on Fri Dec 15 15:26:27 GMT 2023
PRIMARY
WIKIPEDIA
MILACEMIDE
Created by admin on Fri Dec 15 15:26:27 GMT 2023 , Edited by admin on Fri Dec 15 15:26:27 GMT 2023
PRIMARY
ChEMBL
CHEMBL75838
Created by admin on Fri Dec 15 15:26:27 GMT 2023 , Edited by admin on Fri Dec 15 15:26:27 GMT 2023
PRIMARY
EPA CompTox
DTXSID10227786
Created by admin on Fri Dec 15 15:26:27 GMT 2023 , Edited by admin on Fri Dec 15 15:26:27 GMT 2023
PRIMARY
FDA UNII
0HXT24RECU
Created by admin on Fri Dec 15 15:26:27 GMT 2023 , Edited by admin on Fri Dec 15 15:26:27 GMT 2023
PRIMARY
PUBCHEM
53569
Created by admin on Fri Dec 15 15:26:27 GMT 2023 , Edited by admin on Fri Dec 15 15:26:27 GMT 2023
PRIMARY
Related Record Type Details
METABOLIC ENZYME -> SUBSTRATE
SALT/SOLVATE -> PARENT
Related Record Type Details
METABOLITE ACTIVE -> PARENT
METABOLITE ACTIVE -> PRODRUG
Related Record Type Details
ACTIVE MOIETY