MILACEMIDE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H16N2O.ClH
Molecular Weight	180.676
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCCCCNCC(N)=O

InChI

InChIKey=DNSCECUSJKDSKP-UHFFFAOYSA-N

InChI=1S/C7H16N2O.ClH/c1-2-3-4-5-9-6-7(8)10;/h9H,2-6H2,1H3,(H2,8,10);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C7H16N2O
Molecular Weight	144.2147
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1634705 | https://www.ncbi.nlm.nih.gov/pubmed/2769256 | https://adisinsight.springer.com/drugs/800001228 | https://www.ncbi.nlm.nih.gov/pubmed/3516669

Milacemide, a prodrug for glycine, is an inhibitor of the B form of monoamine oxidase. This drug could enhance dopaminergic activity in the brain and could be used as therapy for Parkinson's disease. Milacemide participated in clinical trials as a treatment for senile dementia of the Alzheimer type (SDAT). However, results have shown the drug was not an effective treatment in enhancing cognition in SDAT patients. In addition, milacemide has been tested for antiepileptic efficacy; however, this study was discontinued.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
The novel neuropsychotropic agent milacemide is a specific enzyme-activated inhibitor of brain monoamine oxidase B.	1989 Oct	2769256
Milacemide therapy for Parkinson's disease.	1993	8380487
Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat.	1998 Jul	9755023
[New therapeutic options in Alzheimer's disease].	2006 Apr 16-30	16625510
Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome.	2007 Jul	17659477

Sample Use Guides

In Vivo Use Guide

1200 mg/day milacemide treatment for 1 month (113 patients received milacemide, and 115 patients received placebo

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:06:46 UTC 2023` Edited by `admin` on `Fri Dec 15 16:06:46 UTC 2023`
Record UNII	6XK4G40F6W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MILACEMIDE HYDROCHLORIDE

Official Name

English

MILACEMIDE HCL

Common Name

English

MILACEMIDE HYDROCHLORIDE [MART.]

Common Name

English

2-(Pentylamino)acetamide monohydrochloride

Systematic Name

English

MILACEMIDE HYDROCHLORIDE [USAN]

Common Name

English

CP 1552 S

Code

English

CP-1552 S

Code

English

ACETAMIDE, 2-(PENTYLAMINO)-, MONOHYDROCHLORIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C264