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Details

Stereochemistry ACHIRAL
Molecular Formula C7H16N2O.ClH
Molecular Weight 180.676
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MILACEMIDE HYDROCHLORIDE

SMILES

Cl.CCCCCNCC(N)=O

InChI

InChIKey=DNSCECUSJKDSKP-UHFFFAOYSA-N
InChI=1S/C7H16N2O.ClH/c1-2-3-4-5-9-6-7(8)10;/h9H,2-6H2,1H3,(H2,8,10);1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C7H16N2O
Molecular Weight 144.2147
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Milacemide, a prodrug for glycine, is an inhibitor of the B form of monoamine oxidase. This drug could enhance dopaminergic activity in the brain and could be used as therapy for Parkinson's disease. Milacemide participated in clinical trials as a treatment for senile dementia of the Alzheimer type (SDAT). However, results have shown the drug was not an effective treatment in enhancing cognition in SDAT patients. In addition, milacemide has been tested for antiepileptic efficacy; however, this study was discontinued.

CNS Activity

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Milacemide therapy for Parkinson's disease.
1993

Sample Use Guides

In Vivo Use Guide
1200 mg/day milacemide treatment for 1 month (113 patients received milacemide, and 115 patients received placebo
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:06:46 GMT 2023
Edited
by admin
on Fri Dec 15 16:06:46 GMT 2023
Record UNII
6XK4G40F6W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MILACEMIDE HYDROCHLORIDE
MART.   USAN  
USAN  
Official Name English
MILACEMIDE HCL
Common Name English
MILACEMIDE HYDROCHLORIDE [MART.]
Common Name English
2-(Pentylamino)acetamide monohydrochloride
Systematic Name English
MILACEMIDE HYDROCHLORIDE [USAN]
Common Name English
CP 1552 S
Code English
CP-1552 S
Code English
ACETAMIDE, 2-(PENTYLAMINO)-, MONOHYDROCHLORIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C264
Created by admin on Fri Dec 15 16:06:46 GMT 2023 , Edited by admin on Fri Dec 15 16:06:46 GMT 2023
Code System Code Type Description
CAS
76990-85-7
Created by admin on Fri Dec 15 16:06:46 GMT 2023 , Edited by admin on Fri Dec 15 16:06:46 GMT 2023
PRIMARY
FDA UNII
6XK4G40F6W
Created by admin on Fri Dec 15 16:06:46 GMT 2023 , Edited by admin on Fri Dec 15 16:06:46 GMT 2023
PRIMARY
ChEMBL
CHEMBL75838
Created by admin on Fri Dec 15 16:06:46 GMT 2023 , Edited by admin on Fri Dec 15 16:06:46 GMT 2023
PRIMARY
EPA CompTox
DTXSID70227787
Created by admin on Fri Dec 15 16:06:46 GMT 2023 , Edited by admin on Fri Dec 15 16:06:46 GMT 2023
PRIMARY
NCI_THESAURUS
C81470
Created by admin on Fri Dec 15 16:06:46 GMT 2023 , Edited by admin on Fri Dec 15 16:06:46 GMT 2023
PRIMARY
USAN
X-85
Created by admin on Fri Dec 15 16:06:46 GMT 2023 , Edited by admin on Fri Dec 15 16:06:46 GMT 2023
PRIMARY
PUBCHEM
53568
Created by admin on Fri Dec 15 16:06:46 GMT 2023 , Edited by admin on Fri Dec 15 16:06:46 GMT 2023
PRIMARY
Related Record Type Details
Structure of MILACEMIDE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of MILACEMIDE
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