DIHYDROETORPHINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H35NO4
Molecular Weight	413.5497
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12OC3=C(O)C=CC4=C3[C@@]15CCN(C)[C@]([H])(C4)[C@]56CC[C@@]2(OC)[C@]([H])(C6)[C@](C)(O)CCC

InChI

InChIKey=BRTSNYPDACNMIP-FAWZKKEFSA-N

InChI=1S/C25H35NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,17-18,21,27-28H,5,8-14H2,1-4H3/t17-,18-,21-,22-,23-,24+,25-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C25H35NO4
Molecular Weight	413.5497
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
A protective effect against undesirable increase of dihydroetorphine permeation through damaged skin by using pressure-sensitive adhesive tape with an ethylene-vinyl acetate co-polymer membrane.	2001 Jan	11201250
Tolerance to analgesia and dependence liability by topical application of dihydroetorphine to hairless rats.	2001 Jul 6	11448480
Cell death-inducing activity of opiates in human oral tumor cell lines.	2002 Jan-Feb	12017290
Biochemical characterisation of newly developed beta-etorphine and beta-dihydroetorphine derivatives.	2002 May 3	12020678
Dihydroetorphine: a potent analgesic: pharmacology, toxicology, pharmacokinetics, and clinical effects.	2002 Winter	12481194
Discriminative stimulus and antinociceptive effects of dihydroetorphine in rhesus monkeys.	2003 Apr	12601499
Binding affinity to and dependence on some opioids in Sf9 insect cells expressing human mu-opioid receptor.	2003 Sep	12956932
Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic.	2003 Sep 11	12954070

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:31:24 GMT 2023` Edited by `admin` on `Sat Dec 16 10:31:24 GMT 2023`
Record UNII	QQX8S479YV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIHYDROETORPHINE

Common Name

English

TETRAHYDRO-7.ALPHA.-(1-HYDROXY-1-METHYLBUTYL)-6,14-ENDO-ETHANOORIPAVINE

Common Name

English

Dihydroetorphine [WHO-DD]

Common Name

English

IDS-ND-025

Code

English

6,14-ETHENOMORPHINAN-7-METHANOL, 4,5-EPOXY-18,19-DIHYDRO-3-HYDROXY-6-METHOXY-.ALPHA.,17-DIMETHYL-.ALPHA.-PROPYL-, (.ALPHA.R,5.ALPHA.,7.ALPHA.)

Common Name

English

7,8-DIHYDRO-7.ALPHA.-(1-(R)-HYDROXY-1-METHYLBUTYL)-6,14-ENDOETHANOTETRAHYDROORIPAVINE

Systematic Name

English

Classification Tree Code System Code

DEA NO.

9334