DIHYDROETORPHINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H35NO4
Molecular Weight	413.5497
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DIHYDROETORPHINE

Structure Search

SMILES

CCC[C@@](C)(O)[C@H]1C[C@@]23CC[C@]1(OC)[C@@H]4OC5=C(O)C=CC6=C5[C@]24CCN(C)[C@@H]3C6

InChI

InChIKey=BRTSNYPDACNMIP-FAWZKKEFSA-N

InChI=1S/C25H35NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,17-18,21,27-28H,5,8-14H2,1-4H3/t17-,18-,21-,22-,23-,24+,25-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C25H35NO4
Molecular Weight	413.5497
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:18:10 GMT 2025` Edited by `admin` on `Mon Mar 31 23:18:10 GMT 2025`
Record UNII	QQX8S479YV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IDS-ND-025

Preferred Name

English

DIHYDROETORPHINE

Common Name

English

TETRAHYDRO-7.ALPHA.-(1-HYDROXY-1-METHYLBUTYL)-6,14-ENDO-ETHANOORIPAVINE

Common Name

English

Dihydroetorphine [WHO-DD]

Common Name

English

6,14-ETHENOMORPHINAN-7-METHANOL, 4,5-EPOXY-18,19-DIHYDRO-3-HYDROXY-6-METHOXY-.ALPHA.,17-DIMETHYL-.ALPHA.-PROPYL-, (.ALPHA.R,5.ALPHA.,7.ALPHA.)

Common Name

English

7,8-DIHYDRO-7.ALPHA.-(1-(R)-HYDROXY-1-METHYLBUTYL)-6,14-ENDOETHANOTETRAHYDROORIPAVINE

Systematic Name

English

R-dihydroetorphine

Common Name

English

Classification Tree Code System Code

DEA NO.

9334

Created by admin on Mon Mar 31 23:18:10 GMT 2025 , Edited by admin on Mon Mar 31 23:18:10 GMT 2025

Code System Code Type Description

PUBCHEM

107765

Created by admin on Mon Mar 31 23:18:10 GMT 2025 , Edited by admin on Mon Mar 31 23:18:10 GMT 2025

PRIMARY

EVMPD

SUB195347

Created by admin on Mon Mar 31 23:18:10 GMT 2025 , Edited by admin on Mon Mar 31 23:18:10 GMT 2025

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WIKIPEDIA

DIHYDROETORPHINE

Created by admin on Mon Mar 31 23:18:10 GMT 2025 , Edited by admin on Mon Mar 31 23:18:10 GMT 2025

PRIMARY

EPA CompTox

DTXSID60905082

Created by admin on Mon Mar 31 23:18:10 GMT 2025 , Edited by admin on Mon Mar 31 23:18:10 GMT 2025

PRIMARY

CAS

14357-76-7

Created by admin on Mon Mar 31 23:18:10 GMT 2025 , Edited by admin on Mon Mar 31 23:18:10 GMT 2025

PRIMARY

SMS_ID

100000181584

Created by admin on Mon Mar 31 23:18:10 GMT 2025 , Edited by admin on Mon Mar 31 23:18:10 GMT 2025

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DRUG BANK

DB01450

Created by admin on Mon Mar 31 23:18:10 GMT 2025 , Edited by admin on Mon Mar 31 23:18:10 GMT 2025

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FDA UNII

QQX8S479YV

Created by admin on Mon Mar 31 23:18:10 GMT 2025 , Edited by admin on Mon Mar 31 23:18:10 GMT 2025

PRIMARY

Related Record Type Details


					42M2Y6NU9O

ETORPHINE

PARENT -> DERIVATIVE

Comments:

7,8-dihydro-7α-[1-(R)-hydroxy-1-methylbutyl]-6,14-endoethanotetrahydrooripavine (derivative of etorphine) as per INCB

Amount:


					1PE72K8X46

MU-TYPE OPIOID RECEPTOR

TARGET -> AGONIST

Qualification:

Ki

Amount:


					42M2Y6NU9O

ETORPHINE

PARENT -> DERIVATIVE

Amount:


					2BJ58BX78W

KAPPA-TYPE OPIOID RECEPTOR

TARGET -> AGONIST

Comments:

Opioid agonists acting at nociception/ orphanin FQ, ?-opioid, and ?-opioid receptors may counteract, at least in part, the respiratory depression induced by the activation of the ?-opioid receptor.

Qualification:

Ki

Amount:


					YPU5B72OOI

DIHYDROETORPHINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					EV0PWK6TT6

DELTA-TYPE OPIOID RECEPTOR

TARGET -> AGONIST

Qualification:

Ki

Amount:


					DVO6VKD7IJ

NOCICEPTIN RECEPTOR

TARGET->WEAK AGONIST

Qualification:

Ki

Amount:

Related Record Type Details


					QQX8S479YV

DIHYDROETORPHINE

ACTIVE MOIETY

Comments:

Several thousand times stronger than morphine (between 1000× and 12000× more potent depending what method is used for comparison

Amount: