Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C25H35NO4.ClH |
| Molecular Weight | 450.011 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCC[C@@](C)(O)[C@H]1C[C@@]23CC[C@]1(OC)[C@@H]4OC5=C(O)C=CC6=C5[C@]24CCN(C)[C@@H]3C6
InChI
InChIKey=XRHDQSKAXOSHGA-DTUSRQQPSA-N
InChI=1S/C25H35NO4.ClH/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24;/h6-7,17-18,21,27-28H,5,8-14H2,1-4H3;1H/t17-,18-,21-,22-,23-,24+,25-;/m1./s1
| Molecular Formula | C25H35NO4 |
| Molecular Weight | 413.5497 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence. | 2010-04 |
|
| Tramadol and dihydroetorphine produce synergistic analgesic effect and postpones acute opiate tolerance in rats. | 2005-12-25 |
|
| The orvinols and related opioids--high affinity ligands with diverse efficacy profiles. | 2004 |
|
| Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic. | 2003-09-11 |
|
| Binding affinity to and dependence on some opioids in Sf9 insect cells expressing human mu-opioid receptor. | 2003-09 |
|
| Discriminative stimulus and antinociceptive effects of dihydroetorphine in rhesus monkeys. | 2003-04 |
|
| Cell death-inducing activity of opiates in human oral tumor cell lines. | 2002-05-23 |
|
| Biochemical characterisation of newly developed beta-etorphine and beta-dihydroetorphine derivatives. | 2002-05-03 |
|
| Dihydroetorphine: a potent analgesic: pharmacology, toxicology, pharmacokinetics, and clinical effects. | 2002 |
|
| Tolerance to analgesia and dependence liability by topical application of dihydroetorphine to hairless rats. | 2001-07-06 |
|
| Pharmacokinetic and pharmacodynamic evaluations of a potent analgesic, dihydroetorphine, in hairless rat. | 2001-02 |
|
| A protective effect against undesirable increase of dihydroetorphine permeation through damaged skin by using pressure-sensitive adhesive tape with an ethylene-vinyl acetate co-polymer membrane. | 2001-01 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:17:43 GMT 2025
by
admin
on
Mon Mar 31 23:17:43 GMT 2025
|
| Record UNII |
YPU5B72OOI
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID00935227
Created by
admin on Mon Mar 31 23:17:43 GMT 2025 , Edited by admin on Mon Mar 31 23:17:43 GMT 2025
|
PRIMARY | |||
|
YPU5B72OOI
Created by
admin on Mon Mar 31 23:17:43 GMT 2025 , Edited by admin on Mon Mar 31 23:17:43 GMT 2025
|
PRIMARY | |||
|
155536-45-1
Created by
admin on Mon Mar 31 23:17:43 GMT 2025 , Edited by admin on Mon Mar 31 23:17:43 GMT 2025
|
PRIMARY | |||
|
76966344
Created by
admin on Mon Mar 31 23:17:43 GMT 2025 , Edited by admin on Mon Mar 31 23:17:43 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
PARENT -> SALT/SOLVATE |
|
||
|
|
PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |