U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 18:29:14 GMT 2025
Edited
by admin
on Tue Apr 01 18:29:14 GMT 2025
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
DVO6VKD7IJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
KAPPA-TYPE 3 OPIOID RECEPTOR
Preferred Name English
NOCICEPTIN RECEPTOR
Common Name English
ORPHANIN FQ RECEPTOR
Common Name English
KOR-3
Common Name English
NOP Receptor
Common Name English
nociceptin/orphanin FQ receptor
Common Name English
Code System Code Type Description
FDA UNII
DVO6VKD7IJ
Created by admin on Tue Apr 01 18:29:14 GMT 2025 , Edited by admin on Tue Apr 01 18:29:14 GMT 2025
PRIMARY
UNIPROT
P41146
Created by admin on Tue Apr 01 18:29:14 GMT 2025 , Edited by admin on Tue Apr 01 18:29:14 GMT 2025
PRIMARY
From To
1_123 1_200
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_21
N 1_28
N 1_39
Related Record Type Details
Structure of Buprenorphine
PARTIAL AGONIST->TARGET
[35S]GTP?S Binding, 21.0 +/- 8.4 simulation
EC50
Structure of LEXANOPADOL
AGONIST -> TARGET
Structure of AT-076
INHIBITOR -> TARGET
ANTAGONIST
Structure of GRT-6010
AGONIST -> TARGET
Structure of MK-5757
INHIBITOR -> TARGET
NOCICEPTIN
AGONIST -> TARGET
[35S]GTP?S Binding
EC50
Structure of MCOPPB
AGONIST -> TARGET
Structure of LY-2940094
INHIBITOR -> TARGET
Structure of SUNOBINOP
AGONIST -> TARGET
Structure of NOP-1A C-11
RADIOLIGAND->TARGET
SENREBOTASE
INHIBITOR -> TARGET
Engineered Botulinum Toxins that cleaves NOCICEPTIN RECEPTOR
Structure of CEBRANOPADOL
AGONIST -> TARGET
Structure of DIHYDROETORPHINE
WEAK AGONIST->TARGET
Ki

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_363] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966