U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 12:04:46 GMT 2023
Edited
by admin
on Sat Dec 16 12:04:46 GMT 2023
Protein Type RECEPTOR
Protein Sub Type OPIOID RECEPTOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
2BJ58BX78W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
KAPPA-TYPE OPIOID RECEPTOR
Common Name English
OPRK1
Common Name English
OPRK
Common Name English
KOR-1
Common Name English
κ-Opioid Receptor
Common Name English
K-OR-1
Common Name English
Code System Code Type Description
FDA UNII
2BJ58BX78W
Created by admin on Sat Dec 16 12:04:51 GMT 2023 , Edited by admin on Sat Dec 16 12:04:51 GMT 2023
PRIMARY
PHAROS
P41145
Created by admin on Sat Dec 16 12:04:51 GMT 2023 , Edited by admin on Sat Dec 16 12:04:51 GMT 2023
PRIMARY
UNIPROT
P41145
Created by admin on Sat Dec 16 12:04:51 GMT 2023 , Edited by admin on Sat Dec 16 12:04:51 GMT 2023
PRIMARY
From To
1_131 1_210
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_25
N 1_39
Related Record Type Details
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
[35S]-GTPγS Assay Emax
EC50
INHIBITOR -> TARGET
AGONIST -> TARGET
Ki
INHIBITOR -> TARGET
Assumed Kd similar to all opioid receptors
Kd
AGONIST -> TARGET
Ki
AGONIST -> TARGET
Mouse tail test.
ED50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
IC50
RADIOLIGAND->TARGET
Ki
RADIOLIGAND->TARGET
NON-INHIBITOR->OFF TARGET
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
Ki
AGONIST -> TARGET
TARGET->RADIOLIGAND
Ki
AGONIST -> TARGET
AGONIST -> TARGET
RADIOLIGAND->TARGET
Ki
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Selective for the kappa receptor no mu activity.
BINDING
IC50
RADIOLIGAND->TARGET
Ki
RADIOLIGAND->TARGET
Kd
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
NON-INHIBITOR->OFF TARGET
AGONIST -> TARGET
IC50
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Naloxone is a non-selective and competitive opioid receptor antagonist
IC50
RADIOLIGAND->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
NON-INHIBITOR->OFF TARGET
AGONIST -> TARGET
TARGET -> AGONIST
AGONIST -> TARGET
LIGAND->TARGET
TARGET->RADIOLIGAND
Ki
INHIBITOR -> TARGET
ANTAGONIST
AGONIST -> TARGET
A potent analgesic with a low dependence liability and with no respiratory depressant effects in preliminary pharmacologic screening.
Kd
INHIBITOR -> TARGET
WEAK AGONIST->TARGET
EC50
INHIBITOR -> TARGET
BINDING
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Ki
RADIOLIGAND->TARGET
Ki
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL