Approval Year
Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 12:04:46 GMT 2023
by
admin
on
Sat Dec 16 12:04:46 GMT 2023
|
Protein Type | RECEPTOR |
Protein Sub Type | OPIOID RECEPTOR |
Sequence Origin | HUMAN |
Sequence Type | COMPLETE |
Record UNII |
2BJ58BX78W
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
Code System | Code | Type | Description | ||
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2BJ58BX78W
Created by
admin on Sat Dec 16 12:04:51 GMT 2023 , Edited by admin on Sat Dec 16 12:04:51 GMT 2023
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PRIMARY | |||
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P41145
Created by
admin on Sat Dec 16 12:04:51 GMT 2023 , Edited by admin on Sat Dec 16 12:04:51 GMT 2023
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PRIMARY | |||
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P41145
Created by
admin on Sat Dec 16 12:04:51 GMT 2023 , Edited by admin on Sat Dec 16 12:04:51 GMT 2023
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PRIMARY |
From | To |
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1_131 | 1_210 |
Glycosylation Type | HUMAN |
Glycosylation Link Type | Site |
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N | 1_25 |
N | 1_39 |
Related Record | Type | Details | ||
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AGONIST -> TARGET |
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AGONIST -> TARGET |
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INHIBITOR -> TARGET |
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PARTIAL AGONIST->TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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AGONIST -> TARGET |
[35S]-GTPγS Assay Emax
EC50
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INHIBITOR -> TARGET | |||
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AGONIST -> TARGET |
Ki
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INHIBITOR -> TARGET |
Assumed Kd similar to all opioid receptors
Kd
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AGONIST -> TARGET |
Ki
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AGONIST -> TARGET |
Mouse tail test.
ED50
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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AGONIST -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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RADIOLIGAND->TARGET |
Ki
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RADIOLIGAND->TARGET | |||
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NON-INHIBITOR->OFF TARGET |
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AGONIST -> TARGET |
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AGONIST -> TARGET |
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INHIBITOR -> TARGET |
Ki
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AGONIST -> TARGET |
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TARGET->RADIOLIGAND |
Ki
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AGONIST -> TARGET | |||
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AGONIST -> TARGET |
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RADIOLIGAND->TARGET |
Ki
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INHIBITOR -> TARGET |
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AGONIST -> TARGET |
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AGONIST -> TARGET |
Selective for the kappa receptor no mu activity.
BINDING
IC50
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RADIOLIGAND->TARGET |
Ki
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RADIOLIGAND->TARGET |
Kd
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AGONIST -> TARGET |
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AGONIST -> TARGET |
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AGONIST -> TARGET |
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NON-INHIBITOR->OFF TARGET |
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AGONIST -> TARGET |
IC50
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AGONIST -> TARGET |
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AGONIST -> TARGET |
Ki
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AGONIST -> TARGET | |||
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PARTIAL AGONIST->TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
Naloxone is a non-selective and competitive opioid receptor antagonist
IC50
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RADIOLIGAND->TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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AGONIST -> TARGET | |||
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NON-INHIBITOR->OFF TARGET |
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AGONIST -> TARGET |
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TARGET -> AGONIST | |||
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AGONIST -> TARGET |
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LIGAND->TARGET | |||
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TARGET->RADIOLIGAND |
Ki
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INHIBITOR -> TARGET |
ANTAGONIST
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AGONIST -> TARGET |
A potent analgesic with a low dependence liability and with no respiratory depressant effects in preliminary pharmacologic screening.
Kd
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INHIBITOR -> TARGET | |||
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WEAK AGONIST->TARGET |
EC50
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INHIBITOR -> TARGET |
BINDING
Ki
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AGONIST -> TARGET |
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AGONIST -> TARGET |
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AGONIST -> TARGET |
Ki
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RADIOLIGAND->TARGET |
Ki
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AGONIST -> TARGET |
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Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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Molecular Formula | CHEMICAL |
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MOL_WEIGHT | CHEMICAL |
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