U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 18:08:27 GMT 2025
Edited
by admin
on Tue Apr 01 18:08:27 GMT 2025
Protein Type RECEPTOR
Protein Sub Type OPIOID RECEPTOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
2BJ58BX78W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
K-OR-1
Preferred Name English
KAPPA-TYPE OPIOID RECEPTOR
Common Name English
OPRK1
Common Name English
OPRK
Common Name English
KOR-1
Common Name English
?-Opioid Receptor
Common Name English
Code System Code Type Description
FDA UNII
2BJ58BX78W
Created by admin on Tue Apr 01 18:08:28 GMT 2025 , Edited by admin on Tue Apr 01 18:08:28 GMT 2025
PRIMARY
PHAROS
P41145
Created by admin on Tue Apr 01 18:08:28 GMT 2025 , Edited by admin on Tue Apr 01 18:08:28 GMT 2025
PRIMARY
UNIPROT
P41145
Created by admin on Tue Apr 01 18:08:28 GMT 2025 , Edited by admin on Tue Apr 01 18:08:28 GMT 2025
PRIMARY
From To
1_131 1_210
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_25
N 1_39
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Structure of BENZAMIDINE
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EC50
Structure of NALDEMEDINE
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Structure of SALVINORIN A
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Structure of DIPRENORPHINE
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Kd
Structure of TIFLUADOM, (R)-
AGONIST -> TARGET
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Structure of KETAZOCINE
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Mouse tail test.
ED50
Structure of ATICAPRANT
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Structure of NALDEMEDINE-CARBOXYLIC ACID
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Structure of PF-05089771
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Ki
Structure of ETORPHINE
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DPDPE-Cl binding to guinea pig brain membranes
Ki
Structure of CMX-020
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Structure of Navacaprant
INHIBITOR -> TARGET
IC50
Structure of EKAP
RADIOLIGAND->TARGET
Ki
Structure of LY-2459989 F-18
RADIOLIGAND->TARGET
Structure of THIOBROMADOL
NON-INHIBITOR->OFF TARGET
Structure of CEBRANOPADOL
AGONIST -> TARGET
Structure of NALFURAFINE
AGONIST -> TARGET
Structure of LY-2795050
INHIBITOR -> TARGET
Ki
Structure of DIFELIKEFALIN
AGONIST -> TARGET
Structure of ICI-199441
AGONIST -> TARGET
Structure of NALBUPHINE
AGONIST -> TARGET
Structure of LY-2795050 C-11
RADIOLIGAND->TARGET
Ki
Structure of CYX-6
INHIBITOR -> TARGET
Structure of Anrikefon
AGONIST -> TARGET
Structure of U-50488
AGONIST -> TARGET
Selective for the kappa receptor no mu activity.
BINDING
IC50
Structure of FEKAP C-11
RADIOLIGAND->TARGET
Ki
Structure of U-69593 H-3
RADIOLIGAND->TARGET
Kd
Structure of TIFLUADOM, (S)-
AGONIST -> TARGET
Structure of APADOLINE
AGONIST -> TARGET
BINDING
IC50
Structure of PENTAZOCINE, (+)-
AGONIST -> TARGET
Structure of FENTANYL
NON-INHIBITOR->OFF TARGET
Structure of ASIMADOLINE
AGONIST -> TARGET
IC50
Structure of NIRAVOLINE
AGONIST -> TARGET
Structure of MORPHINE
AGONIST -> TARGET
Ki
Structure of Oxycodone
AGONIST -> TARGET
Structure of Samidorphan
PARTIAL AGONIST->TARGET
Structure of NALDEMEDINE 3-O-.BETA.-D-GLUCURONIDE
INHIBITOR -> TARGET
Structure of NALOXONE
INHIBITOR -> TARGET
Naloxone is a non-selective and competitive opioid receptor antagonist
IC50
Structure of LY-2459989 C-11
RADIOLIGAND->TARGET
Structure of NALDEMEDINE 6-O-.BETA.-D-GLUCURONIDE
INHIBITOR -> TARGET
Structure of NOR-NALDEMEDINE
INHIBITOR -> TARGET
Structure of BUTORPHANOL
AGONIST -> TARGET
Structure of PF-05150122
INHIBITOR->OFF-TARGET
Ki
Structure of DERMORPHIN
NON-INHIBITOR->OFF TARGET
3-METHYLFENTANYL
AGONIST -> TARGET
Structure of CEBRANOPADOL
TARGET -> AGONIST
Structure of RB-64
AGONIST -> TARGET
Structure of LY-2459989
LIGAND->TARGET
Structure of FEKAP
TARGET->RADIOLIGAND
Ki
Structure of AT-076
INHIBITOR -> TARGET
ANTAGONIST
Structure of DIHYDROETORPHINE
AGONIST -> TARGET
Opioid agonists acting at nociception/ orphanin FQ, ?-opioid, and ?-opioid receptors may counteract, at least in part, the respiratory depression induced by the activation of the ?-opioid receptor.
Ki
3-METHYLTHIOFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of BREMAZOCINE
AGONIST -> TARGET
A potent analgesic with a low dependence liability and with no respiratory depressant effects in preliminary pharmacologic screening.
Kd
Structure of NORBINALTORPHIMINE
INHIBITOR -> TARGET
Structure of ENADOLINE
AGONIST -> TARGET
Structure of U-47700
WEAK AGONIST->TARGET
EC50
Structure of Buprenorphine
INHIBITOR -> TARGET
BINDING
Ki
Structure of LEVORPHANOL
AGONIST -> TARGET
Ki
Structure of JDTIC
AGONIST -> TARGET
Structure of PENTAZOCINE
AGONIST -> TARGET
Structure of Tifluadom
AGONIST -> TARGET
Ki
Structure of EKAP C-11
RADIOLIGAND->TARGET
Ki
Structure of ELUXADOLINE
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL
NIH
NCATS
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