MAGNESIUM

US Approved OTC

First marketed in 1921

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Mg
Molecular Weight	24.3051
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[MgH4]

InChI

InChIKey=RSHAOIXHUHAZPM-UHFFFAOYSA-N

InChI=1S/Mg.2H

HIDE SMILES / InChI

Molecular Formula	Mg
Molecular Weight	24.3051
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: DOI: 10.2903/j.efsa.2008.883http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2013.3444/pdfhttps://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdfhttps://hazmap.nlm.nih.gov/category-details?table=copytblagents&id=1640http://www.db-pharma.com/anglais/49.pdfhttp://www.sciencedirect.com/science/article/pii/004484868990080Xhttp://www.internationalcrystal.net/optics_11.htm | https://www.ncbi.nlm.nih.gov/pubmed/27792982 | https://www.ncbi.nlm.nih.gov/pubmed/26952467 | https://www.ncbi.nlm.nih.gov/pubmed/27995243https://www.scbt.com/scbt/product/magnesium-nitrate-hexahydrate-13446-18-9 | https://www.ncbi.nlm.nih.gov/pubmed/18964415 | https://www.ncbi.nlm.nih.gov/pubmed/2843308http://dx.doi.org/10.1155/2015/498932 | http://iicbe.org/upload/4152C514072.pdfhttps://www.drugs.com/ppa/magnesium-chloride.htmldoi: 10.1081/SCC-120022479https://www.ncbi.nlm.nih.gov/pubmed/351265https://www.ncbi.nlm.nih.gov/pubmed/15480451 | https://www.scbt.com/scbt/product/magnesium-iodide-10377-58-9https://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1https://www.drugs.com/dosage/magnesium-lactate.html
Curator's Comment:: description was created based on several sources, including: http://drugpamphlet.blogspot.ru/2012/04/epimag.html | http://noillen.bitballoon.com/nutritional-suppleme5/magnesium-citrate-pr4451.html | http://www.webmd.com/drugs/2/drug-522-2202/magnesium-citrate/details

Magnesium lactate is a naturally occurring mineral that is needed in the body to support the function of the heart, nervous system, and digestive system. Magnesium lactate is used as a mineral supplement to treat magnesium deficiency.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
action potential 66 Target ID: GO:0001508 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12225296	Inhibitor 7728
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: http://www.webstercare.com.au/files/continuing_education/wc_continuing_edu_dec2011.pdf \| https://www.ncbi.nlm.nih.gov/pubmed/26812001	Modulator 780
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: http://www.webmd.com/drugs/2/drug-10702-5106/magnesium-dr/details	Modulator 780
oxalate metabolic process 66 Target ID: GO:0033609 Sources: https://www.medicinep.com/epimag-for-cases-of-oxaluria-and-mild-laxative-to-relieve-constipation-2918.html	Modulator 780
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: https://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1	Modulator 780
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: https://www.standardprocess.com/Products/Standard-Process/Magnesium-Lactate#.WP-FxUXyizc \| https://www.drugs.com/mtm/magnesium-lactate.html	Interacts 318
Protein S100-A8 66 Target ID: P05109 Gene ID: 6279.0 Gene Symbol: S100A8 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8061680	Binding Agent 996

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2502
Unknown 2502
Bone disease 69 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27792982	Primary	Basic research	Unknown Approved Use Unknown
Bacterial infections 230 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27995243	Primary	Preclinical	Unknown Approved Use Unknown
Bronchial spasm 78 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20647692	Primary	Preclinical	Unknown Approved Use Unknown
Unknown 2502
Unknown 2502
Unknown 2502
Preeclampsia 84 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdf	Preventing	Approved 8043	MAGNESIUM SULFATE Approved Use INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date 7.9038723E11
Eclampsia 69 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdf	Primary	Approved 8043	MAGNESIUM SULFATE Approved Use INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date 7.9038723E11
Preparation for colonoscopy 66 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/204553s001lbl.pdf	Diagnostic	Approved 8043	ColPrep Kit Approved Use INDICATIONS AND USAGE ColPrep Kit is indicated for cleansing of the colon as a preparation for colonoscopy in adults Launch Date 1.48279683E12
Atrial fibrillation 130 Sources: https://clinicaltrials.gov/ct2/show/NCT00965874	Primary	Phase III 643	MAGNESIUM SULFATE Approved Use INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date 7.9038723E11
Unknown 2502
Magnesium deficiency 67 Sources: https://www.blackmores.com.au/products/magmin	Curative	Approved 8043	MagMin Approved Use Magnesium aspartate (MagMin) is indicated for patients with documented hypomagnesaemia.
Unknown 2502
Magnesium deficiency 67 Sources: http://www.db-pharma.com/anglais/49.pdf	Curative	Not Provided 492	DELBIASE Approved Use Unknown
Eclampsia 69 Sources: http://www.medicatione.com/?c=drug&s=delbiase&ingredient=magnesium%20bromide/magnesium%20chloride	Primary	Not Provided 492	DELBIASE Approved Use Unknown
Convulsions 71 Sources: http://www.medicatione.com/?c=drug&s=delbiase&ingredient=magnesium%20bromide/magnesium%20chloride	Primary	Not Provided 492	DELBIASE Approved Use Unknown
Magnesium deficiency 67 Sources: http://www.meritpharm.com/wp-content/uploads/2014/03/Chloromag.Magnesium-Chloride.MSDS_.pdf	Curative	Approved 8043	Magnesium Chloride Approved Use Magnesium Chloride injection is indicated as an electrolyte replenisher in magnesium deficiencies
Fibromyalgia 87 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26343101	Palliative	Phase II 1101	Magnesium Chloride Approved Use Unknown
Stroke 138 Sources: https://clinicaltrials.gov/ct2/show/NCT00933868	Palliative	Phase III 643	Magnesium Chloride Approved Use Unknown
Oxaluria 66 Sources: http://drugpamphlet.blogspot.ru/2012/04/epimag.html	Primary	Approved 8043	EPIMAG Approved Use Magnesium citrate is indicated in cases of oxaluria, to prevent recurrence of calcium oxalate kidney stones.
Constipation 112 Sources: http://drugpamphlet.blogspot.ru/2012/04/epimag.html	Primary	Approved 8043	EPIMAG Approved Use Used to relief of occasional constipation (irregularity).
Magnesium deficiency 67 Sources: https://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1	Curative	Approved 8043	Magnesium Citrate Approved Use Magnesium citrate is indicated to supports magnesium nutritional adequacy.
Unknown 2502
Magnesium deficiency 67 Sources: https://www.standardprocess.com/Products/Standard-Process/Magnesium-Lactate#.WP-FxUXyizc https://www.drugs.com/mtm/magnesium-lactate.html	Curative	Approved 8043	Unknown Approved Use Magnesium lactate is a naturally occurring mineral that is needed in the body to support the function of the heart, nervous system, and digestive system. Magnesium lactate is used as a mineral supplement to treat magnesium deficiency.

PubMed

Title	Date	PubMed
Effects of manganese, calcium, magnesium and lithium on the ouabain-induced seizure.	1977	608666
[Magnesium--an alternative in treatment resistant tachyarrhythmias].	1977 May 30	867390
Serum calcium and magnesium levels in schizophrenia. II. Possible relationship to extrapyramidal symptoms.	1979 Nov	496555
Symptomatic hypercalcaemia precipitated by magnesium therapy.	1985 Jan	3991404
Regulation of membrane histamine H1-receptor binding sites by guanine nucleotides, mono- and divalent cations.	1986 Apr	3728201
Metal: ATP characteristics of insulin- and epidermal growth factor-stimulated phosphorylation in detergent extracts of rat liver plasma membranes.	1986 Sep	3527812
Decreased intracellular free magnesium in erythrocytes of spontaneously hypertensive rats.	1987 Mar 30	3566749
A comparison of two digestion procedures for the determination of selenium in biological material.	1987 Oct	18964415
Fluorimetry of selenium in body fluids after digestion with nitric acid, magnesium nitrate hexahydrate, and hydrochloric acid.	1988 Sep	2843308
Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.	1988 Sep 1	2900677
Effect of magnesium diet in gentamicin-induced acute renal failure in rats.	1989	2915758
Polylysine specifically activates the insulin-dependent insulin receptor protein kinase.	1989 Jun 15	2542339
[Arrhythmogenic effect of flecainide--treatment with i.v. magnesium].	1989 Sep	2510412
Cocaine-induced cerebral vascular damage can be ameliorated by Mg2+ in rat brain.	1990 Feb 5	2314626
Role of magnesium in cardiac tachyarrhythmias.	1990 Jun 19	2353670
['Cardiac ballet' with and without amiodarone].	1993 Jan 13	8421775
Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake.	1994 Feb 18	8106444
Cocaine-induced cerebrovasospasm and its possible mechanism of action.	1994 Mar	8138965
Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid.	1995 Mar	7891159
Effects of felbamate on muscarinic and metabotropic-glutamate agonist-mediated responses and magnesium-free or 4-aminopyridine-induced epileptiform activity in guinea pig olfactory cortex neurons in vitro.	1996 Jun	8667248
Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease.	1999 Jul 15	10426331
Some magnesium salts and a mixture of magnesium and calcium salts accelerate skin barrier recovery.	1999 Oct	10552215
Trifluoromethanesulfonic anhydride-promoted alpha-bromination of ketones with grignard reagent or magnesium bromide.	2000 Dec	11145159
Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats.	2000 Jul	10930190
An efficient chiral moderator prepared from inexpensive (+)-3-carene: synthesis of the HIV-1 non-nucleoside reverse transcriptase inhibitor DPC 963.	2000 Oct 5	11009360
Magnesium bromide mediated highly diastereoselective heterogeneous hydrogenation of olefins.	2002 Apr 18	11950359
Synthesis of a non-heme template for attaching four peptides: an approach to artificial iron(II)-containing peroxidases.	2004 Jan 23	14725436
Formation of formal disilene fluoride adducts.	2008 Dec 24	19053480
Inhaled magnesium fluoride reverse bronchospasma.	2010	20647692
Magnesium imide: synthesis and structure determination of an unconventional alkaline earth imide from decomposition of magnesium amide.	2011 Feb 7	21190329
C-H functionalization polycondensation of chlorothiophenes in the presence of nickel catalyst with stoichiometric or catalytically generated magnesium amide.	2011 Jun 29	21634794
Tris(oxazolinyl)boratomagnesium-catalyzed cross-dehydrocoupling of organosilanes with amines, hydrazine, and ammonia.	2011 Oct 26	21958426
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.	2013	23516525
Fluorescence lifetime analysis and effect of magnesium ions on binding of NADH to human aldehyde dehydrogenase 1.	2013 Feb 25	23295229
Catalytic contribution of threonine 244 in human ALDH2.	2013 Feb 25	23295226
Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis.	2013 Jun 15	23789114
Assessment of infantile mineral imbalances in autism spectrum disorders (ASDs).	2013 Nov 11	24284360
Effects of three kinds of organic acids on phosphorus recovery by magnesium ammonium phosphate (MAP) crystallization from synthetic swine wastewater.	2014 Apr	24296029
Precipitation of amorphous magnesium ammonium phosphate: is it a precursor for staghorn stones?	2014 Jun	24643665
Evaluation of enantiomeric purity of magnesium-L-aspartate dihydrate.	2015 Jan	25262412
Assessment of pulmonary toxicity of MgO nanoparticles in rats.	2015 Mar	24096598
Preparation and optimization of a drug delivery system based on berberine chloride-immobilized MgAl hydrotalcite.	2016 Jun 15	27109050
No effect of multivitamin supplementation on central blood pressure in healthy older people: A randomized controlled trial.	2016 Mar	26812001
MgF2-coated porous magnesium/alumina scaffolds with improved strength, corrosion resistance, and biological performance for biomedical applications.	2016 May	26952467
A Soft Grip: Magnesium Complexes with a Phosphine-Modified Phosphonium Diylidic Lewis Base.	2016 Nov 21	27775201
Nano-layered magnesium fluoride reservoirs on biomaterial surfaces strengthen polymorphonuclear leukocyte resistance to bacterial pathogens.	2017 Jan 5	27995243
Fast sono assisted ferrofluid mediated silver super - Adsorption over magnesium ferrite-copper sulfide chalcogenide with the aid of multivariate optimization.	2017 Jul	28427663
Magnesium amide catalyzed selective hydroboration of esters.	2017 Mar 27	28265632
Effect of power ultrasound on crystallization characteristics of magnesium ammonium phosphate.	2017 May	28069191
Antenatal Exposure to Magnesium Sulfate and Spontaneous Intestinal Perforation and Necrotizing Enterocolitis in Extremely Preterm Neonates.	2017 Oct	28494498

Patents

Sample Use Guides

In Vivo Use Guide

The daily exposure levels were equivalent to approximately 240 mg of magnesium and 2600 mg of L-aspartic acid for adults.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Jun 26 13:02:54 UTC 2021` Edited by `admin` on `Sat Jun 26 13:02:54 UTC 2021`
Record UNII	I38ZP9992A
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MAGNESIUM

Systematic Name

English

MAGNESIUM METALLICUM

Common Name

English

MAGNESIUM [MI]

Common Name

English

MAGNESIUM [WHO-DD]

Common Name

English

MAGNESIUM METALLICUM [HPUS]

Common Name

English

MAGNESIUM [VANDF]

Common Name

English

MAGNESIUM POWDER

Official Name

English

MAGNESIUM [HSDB]

Common Name

English

Common Name

English

MAGNESIUM POWDER [INCI]

Common Name

English

Classification Tree Code System Code

LOINC

29365-4