U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Mg
Molecular Weight 24.305
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAGNESIUM

SMILES

[Mg]

InChI

InChIKey=RSHAOIXHUHAZPM-UHFFFAOYSA-N
InChI=1S/Mg.2H

HIDE SMILES / InChI

Molecular Formula Mg
Molecular Weight 24.305
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Struvite, a crystalline substance first identified in the 18th century, is composed of magnesium ammonium phosphate. Struvite urinary stones are also known as ‘infection stones’, and account for 15%-20% of all urinary stones. Bacterial urease, usually from a Proteus species, is responsible for the chemical changes in urine which result in struvite formation.

Originator

Curator's Comment: Ulex, a Swedish geologist, is generally credited with introduction of the term struvite in1845

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

1995
Primary
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

1995
Diagnostic
ColPrep Kit

Approved Use

INDICATIONS AND USAGE ColPrep Kit is indicated for cleansing of the colon as a preparation for colonoscopy in adults

Launch Date

2016
Primary
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

1995
Curative
MagMin

Approved Use

Magnesium aspartate (MagMin) is indicated for patients with documented hypomagnesaemia.
Curative
DELBIASE

Approved Use

Unknown
Primary
DELBIASE

Approved Use

Unknown
Primary
DELBIASE

Approved Use

Unknown
Curative
Magnesium Chloride

Approved Use

Magnesium Chloride injection is indicated as an electrolyte replenisher in magnesium deficiencies
Palliative
Magnesium Chloride

Approved Use

Unknown
Palliative
Magnesium Chloride

Approved Use

Unknown
Primary
EPIMAG

Approved Use

Magnesium citrate is indicated in cases of oxaluria, to prevent recurrence of calcium oxalate kidney stones.
Primary
EPIMAG

Approved Use

Used to relief of occasional constipation (irregularity).
Curative
Magnesium Citrate

Approved Use

Magnesium citrate is indicated to supports magnesium nutritional adequacy.
Curative
Unknown

Approved Use

Magnesium lactate is a naturally occurring mineral that is needed in the body to support the function of the heart, nervous system, and digestive system. Magnesium lactate is used as a mineral supplement to treat magnesium deficiency.
PubMed

PubMed

TitleDatePubMed
Effects of manganese, calcium, magnesium and lithium on the ouabain-induced seizure.
1977
Evidence for separate peptide sequences related to the lipolytic and magnesium-accumulating activities of ACTH. Analogy with adrenergic receptors.
1977 Apr
[Magnesium--an alternative in treatment resistant tachyarrhythmias].
1977 May 30
Serum calcium and magnesium levels in schizophrenia. II. Possible relationship to extrapyramidal symptoms.
1979 Nov
Characterization of the prolactin receptor in human prostate.
1983 Nov
Symptomatic hypercalcaemia precipitated by magnesium therapy.
1985 Jan
Regulation of membrane histamine H1-receptor binding sites by guanine nucleotides, mono- and divalent cations.
1986 Apr
Metal: ATP characteristics of insulin- and epidermal growth factor-stimulated phosphorylation in detergent extracts of rat liver plasma membranes.
1986 Sep
Decreased intracellular free magnesium in erythrocytes of spontaneously hypertensive rats.
1987 Mar 30
Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.
1988 Sep 1
Effect of magnesium diet in gentamicin-induced acute renal failure in rats.
1989
Polylysine specifically activates the insulin-dependent insulin receptor protein kinase.
1989 Jun 15
[Arrhythmogenic effect of flecainide--treatment with i.v. magnesium].
1989 Sep
Cocaine-induced cerebral vascular damage can be ameliorated by Mg2+ in rat brain.
1990 Feb 5
Role of magnesium in cardiac tachyarrhythmias.
1990 Jun 19
Modulation of mu, delta and kappa opioid receptors in rat brain by metal ions and histidine.
1990 May
Magnesium inhibits the hypertensive but not the cardiotonic actions of low-dose epinephrine.
1991 Jun
['Cardiac ballet' with and without amiodarone].
1993 Jan 13
Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake.
1994 Feb 18
Cocaine-induced cerebrovasospasm and its possible mechanism of action.
1994 Mar
Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid.
1995 Mar
Effects of felbamate on muscarinic and metabotropic-glutamate agonist-mediated responses and magnesium-free or 4-aminopyridine-induced epileptiform activity in guinea pig olfactory cortex neurons in vitro.
1996 Jun
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.
2007 Sep
[The characterization of central neuromediation in rats fed with magnesium-deprived diet before and after magnesium replenishment].
2008 Jul
Interactions between magnesium and psychotropic drugs.
2008 Jun
Treatment of migraine with prophylactic drugs.
2008 Oct
Cocaine use disorders and serum magnesium profile.
2009
Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect.
2009 Dec
Differential binding of inorganic particles to MARCO.
2009 Jan
AZT-induced oxidative cardiovascular toxicity: attenuation by Mg-supplementation.
2009 Jun
The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation.
2009 Jun 23
Magnesium modifies fentanyl-induced local antinociception and hyperalgesia.
2009 Nov
Evidence that TRPM7 is required for breast cancer cell proliferation.
2009 Sep
Hair tissue mineral analysis and metabolic syndrome.
2009 Sep
Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2).
2010 Apr 13
Involvement of transient receptor potential melastatin-related 7 (TRPM7) channels in cadmium uptake and cytotoxicity in MC3T3-E1 osteoblasts.
2010 Dec 15
Carcinogenic heavy metals replace Ca2+ for DNA binding and annealing activities of mono-ubiquitinated annexin A1 homodimer.
2010 Oct 1
Metals affect the structure and activity of human plasminogen activator inhibitor-1. II. Binding affinity and conformational changes.
2011 Feb
Metals affect the structure and activity of human plasminogen activator inhibitor-1. I. Modulation of stability and protease inhibition.
2011 Feb
Millimolar Mn2+ influences agonist binding to 5-HT1A receptors by inhibiting guanosine nucleotide binding to receptor-coupled G-proteins.
2011 Jan
Mechanically enforced bond dissociation reports synergistic influence of Mn2+ and Mg2+ on the interaction between integrin α7β1 and invasin.
2011 Jul-Aug
Hypoxia induces an increase in intracellular magnesium via transient receptor potential melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro.
2011 Jun 10
NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2.
2011 May 30
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.
2013
Warfarin accelerates ectopic mineralization in Abcc6(-/-) mice: clinical relevance to pseudoxanthoma elasticum.
2013 Apr
Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes.
2013 Feb 15
Fluorescence lifetime analysis and effect of magnesium ions on binding of NADH to human aldehyde dehydrogenase 1.
2013 Feb 25
Catalytic contribution of threonine 244 in human ALDH2.
2013 Feb 25
Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis.
2013 Jun 15
Assessment of infantile mineral imbalances in autism spectrum disorders (ASDs).
2013 Nov 11
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Rats: MgF2 dissolved in acetic acid (Mg=0.08 mM, F=0.084 mM) was delivered in the aerosol form https://www.ncbi.nlm.nih.gov/pubmed/20647692
Murine osteomyelitis model: medical pure titanium plates in size of 10 mm × 10 mm × 1 mm were used for the deposition of Magnesium Fluoride (MgF2) film.
Route of Administration: Topical
In Vitro Use Guide
Curator's Comment: Magnesium Chloride
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:09:10 GMT 2023
Edited
by admin
on Fri Dec 15 16:09:10 GMT 2023
Record UNII
I38ZP9992A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MAGNESIUM
HSDB   MI   VANDF   WHO-DD  
Systematic Name English
MAGNESIUM METALLICUM
HPUS  
Common Name English
MAGNESIUM [MI]
Common Name English
MAGNESIUM METALLICUM [HPUS]
Common Name English
MAGNESIUM [VANDF]
Common Name English
MAGNESIUM POWDER
INCI  
INCI  
Official Name English
MAGNESIUM [HSDB]
Common Name English
MG
Common Name English
MAGNESIUM POWDER [INCI]
Common Name English
Magnesium [WHO-DD]
Common Name English
Classification Tree Code System Code
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CFR 21 CFR 176.170
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CFR 21 CFR 102.23
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DSLD 82 (Number of products:11063)
Created by admin on Fri Dec 15 16:09:10 GMT 2023 , Edited by admin on Fri Dec 15 16:09:10 GMT 2023
Code System Code Type Description
DAILYMED
I38ZP9992A
Created by admin on Fri Dec 15 16:09:10 GMT 2023 , Edited by admin on Fri Dec 15 16:09:10 GMT 2023
PRIMARY
HSDB
654
Created by admin on Fri Dec 15 16:09:10 GMT 2023 , Edited by admin on Fri Dec 15 16:09:10 GMT 2023
PRIMARY
FDA UNII
I38ZP9992A
Created by admin on Fri Dec 15 16:09:10 GMT 2023 , Edited by admin on Fri Dec 15 16:09:10 GMT 2023
PRIMARY
PUBCHEM
5462224
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PRIMARY
SMS_ID
100000091621
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PRIMARY
DRUG BANK
DB14513
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PRIMARY
CAS
7439-95-4
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PRIMARY
MERCK INDEX
m6987
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PRIMARY Merck Index
ECHA (EC/EINECS)
231-104-6
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PRIMARY
EPA CompTox
DTXSID0049658
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PRIMARY
CFR
21 CFR 862.1495
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PRIMARY
NCI_THESAURUS
C68264
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PRIMARY
WIKIPEDIA
Magnesium
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PRIMARY
MESH
D008274
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PRIMARY
CHEBI
25107
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PRIMARY
WIKIPEDIA
Magnesium (medical use)
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PRIMARY
RXCUI
6574
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PRIMARY RxNorm
EVMPD
SUB14407MIG
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PRIMARY
NCI_THESAURUS
C1505
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CONCEPT Dietary Supplement
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
Nutritional value per 100 g (3.5 oz) - 21 mg (6%)
Related Record Type Details
ACTIVE MOIETY