U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Mg
Molecular Weight 24.3051
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAGNESIUM

SMILES

[MgH4]

InChI

InChIKey=RSHAOIXHUHAZPM-UHFFFAOYSA-N
InChI=1S/Mg.2H

HIDE SMILES / InChI

Molecular Formula Mg
Molecular Weight 24.3051
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Magnesium lactate is a naturally occurring mineral that is needed in the body to support the function of the heart, nervous system, and digestive system. Magnesium lactate is used as a mineral supplement to treat magnesium deficiency.

Originator

Curator's Comment:: Ulex, a Swedish geologist, is generally credited with introduction of the term struvite in1845

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

7.9038723E11
Primary
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

7.9038723E11
Diagnostic
ColPrep Kit

Approved Use

INDICATIONS AND USAGE ColPrep Kit is indicated for cleansing of the colon as a preparation for colonoscopy in adults

Launch Date

1.48279683E12
Primary
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

7.9038723E11
Curative
MagMin

Approved Use

Magnesium aspartate (MagMin) is indicated for patients with documented hypomagnesaemia.
Curative
DELBIASE

Approved Use

Unknown
Primary
DELBIASE

Approved Use

Unknown
Primary
DELBIASE

Approved Use

Unknown
Curative
Magnesium Chloride

Approved Use

Magnesium Chloride injection is indicated as an electrolyte replenisher in magnesium deficiencies
Palliative
Magnesium Chloride

Approved Use

Unknown
Palliative
Magnesium Chloride

Approved Use

Unknown
Primary
EPIMAG

Approved Use

Magnesium citrate is indicated in cases of oxaluria, to prevent recurrence of calcium oxalate kidney stones.
Primary
EPIMAG

Approved Use

Used to relief of occasional constipation (irregularity).
Curative
Magnesium Citrate

Approved Use

Magnesium citrate is indicated to supports magnesium nutritional adequacy.
Curative
Unknown

Approved Use

Magnesium lactate is a naturally occurring mineral that is needed in the body to support the function of the heart, nervous system, and digestive system. Magnesium lactate is used as a mineral supplement to treat magnesium deficiency.
PubMed

PubMed

TitleDatePubMed
Effects of manganese, calcium, magnesium and lithium on the ouabain-induced seizure.
1977
[Magnesium--an alternative in treatment resistant tachyarrhythmias].
1977 May 30
Serum calcium and magnesium levels in schizophrenia. II. Possible relationship to extrapyramidal symptoms.
1979 Nov
Symptomatic hypercalcaemia precipitated by magnesium therapy.
1985 Jan
Regulation of membrane histamine H1-receptor binding sites by guanine nucleotides, mono- and divalent cations.
1986 Apr
Metal: ATP characteristics of insulin- and epidermal growth factor-stimulated phosphorylation in detergent extracts of rat liver plasma membranes.
1986 Sep
Decreased intracellular free magnesium in erythrocytes of spontaneously hypertensive rats.
1987 Mar 30
A comparison of two digestion procedures for the determination of selenium in biological material.
1987 Oct
Fluorimetry of selenium in body fluids after digestion with nitric acid, magnesium nitrate hexahydrate, and hydrochloric acid.
1988 Sep
Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.
1988 Sep 1
Effect of magnesium diet in gentamicin-induced acute renal failure in rats.
1989
Polylysine specifically activates the insulin-dependent insulin receptor protein kinase.
1989 Jun 15
[Arrhythmogenic effect of flecainide--treatment with i.v. magnesium].
1989 Sep
Cocaine-induced cerebral vascular damage can be ameliorated by Mg2+ in rat brain.
1990 Feb 5
Role of magnesium in cardiac tachyarrhythmias.
1990 Jun 19
['Cardiac ballet' with and without amiodarone].
1993 Jan 13
Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake.
1994 Feb 18
Cocaine-induced cerebrovasospasm and its possible mechanism of action.
1994 Mar
Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid.
1995 Mar
Effects of felbamate on muscarinic and metabotropic-glutamate agonist-mediated responses and magnesium-free or 4-aminopyridine-induced epileptiform activity in guinea pig olfactory cortex neurons in vitro.
1996 Jun
Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease.
1999 Jul 15
Some magnesium salts and a mixture of magnesium and calcium salts accelerate skin barrier recovery.
1999 Oct
Trifluoromethanesulfonic anhydride-promoted alpha-bromination of ketones with grignard reagent or magnesium bromide.
2000 Dec
Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats.
2000 Jul
An efficient chiral moderator prepared from inexpensive (+)-3-carene: synthesis of the HIV-1 non-nucleoside reverse transcriptase inhibitor DPC 963.
2000 Oct 5
Magnesium bromide mediated highly diastereoselective heterogeneous hydrogenation of olefins.
2002 Apr 18
Synthesis of a non-heme template for attaching four peptides: an approach to artificial iron(II)-containing peroxidases.
2004 Jan 23
Formation of formal disilene fluoride adducts.
2008 Dec 24
Inhaled magnesium fluoride reverse bronchospasma.
2010
Magnesium imide: synthesis and structure determination of an unconventional alkaline earth imide from decomposition of magnesium amide.
2011 Feb 7
C-H functionalization polycondensation of chlorothiophenes in the presence of nickel catalyst with stoichiometric or catalytically generated magnesium amide.
2011 Jun 29
Tris(oxazolinyl)boratomagnesium-catalyzed cross-dehydrocoupling of organosilanes with amines, hydrazine, and ammonia.
2011 Oct 26
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.
2013
Fluorescence lifetime analysis and effect of magnesium ions on binding of NADH to human aldehyde dehydrogenase 1.
2013 Feb 25
Catalytic contribution of threonine 244 in human ALDH2.
2013 Feb 25
Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis.
2013 Jun 15
Assessment of infantile mineral imbalances in autism spectrum disorders (ASDs).
2013 Nov 11
Effects of three kinds of organic acids on phosphorus recovery by magnesium ammonium phosphate (MAP) crystallization from synthetic swine wastewater.
2014 Apr
Precipitation of amorphous magnesium ammonium phosphate: is it a precursor for staghorn stones?
2014 Jun
Evaluation of enantiomeric purity of magnesium-L-aspartate dihydrate.
2015 Jan
Assessment of pulmonary toxicity of MgO nanoparticles in rats.
2015 Mar
Preparation and optimization of a drug delivery system based on berberine chloride-immobilized MgAl hydrotalcite.
2016 Jun 15
No effect of multivitamin supplementation on central blood pressure in healthy older people: A randomized controlled trial.
2016 Mar
MgF2-coated porous magnesium/alumina scaffolds with improved strength, corrosion resistance, and biological performance for biomedical applications.
2016 May
A Soft Grip: Magnesium Complexes with a Phosphine-Modified Phosphonium Diylidic Lewis Base.
2016 Nov 21
Nano-layered magnesium fluoride reservoirs on biomaterial surfaces strengthen polymorphonuclear leukocyte resistance to bacterial pathogens.
2017 Jan 5
Fast sono assisted ferrofluid mediated silver super - Adsorption over magnesium ferrite-copper sulfide chalcogenide with the aid of multivariate optimization.
2017 Jul
Magnesium amide catalyzed selective hydroboration of esters.
2017 Mar 27
Effect of power ultrasound on crystallization characteristics of magnesium ammonium phosphate.
2017 May
Antenatal Exposure to Magnesium Sulfate and Spontaneous Intestinal Perforation and Necrotizing Enterocolitis in Extremely Preterm Neonates.
2017 Oct
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Sources: DOI: 10.2903/j.efsa.2008.883
Curator's Comment:: Rats: MgF2 dissolved in acetic acid (Mg=0.08 mM, F=0.084 mM) was delivered in the aerosol form https://www.ncbi.nlm.nih.gov/pubmed/20647692
The daily exposure levels were equivalent to approximately 240 mg of magnesium and 2600 mg of L-aspartic acid for adults.
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment:: Magnesium Chloride
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 13:02:54 UTC 2021
Edited
by admin
on Sat Jun 26 13:02:54 UTC 2021
Record UNII
I38ZP9992A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MAGNESIUM
HSDB   MI   VANDF   WHO-DD  
Systematic Name English
MAGNESIUM METALLICUM
HPUS  
Common Name English
MAGNESIUM [MI]
Common Name English
MAGNESIUM [WHO-DD]
Common Name English
MAGNESIUM METALLICUM [HPUS]
Common Name English
MAGNESIUM [VANDF]
Common Name English
MAGNESIUM POWDER
INCI  
INCI  
Official Name English
MAGNESIUM [HSDB]
Common Name English
MG
Common Name English
MAGNESIUM POWDER [INCI]
Common Name English
Classification Tree Code System Code
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WHO-ATC A12CC01
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WHO-ATC B05XA11
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CFR 21 CFR 176.170
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CFR 21 CFR 102.23
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DSLD 82 (Number of products:11063)
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Code System Code Type Description
HSDB
654
Created by admin on Sat Jun 26 13:02:54 UTC 2021 , Edited by admin on Sat Jun 26 13:02:54 UTC 2021
PRIMARY
FDA UNII
I38ZP9992A
Created by admin on Sat Jun 26 13:02:54 UTC 2021 , Edited by admin on Sat Jun 26 13:02:54 UTC 2021
PRIMARY
PUBCHEM
5462224
Created by admin on Sat Jun 26 13:02:54 UTC 2021 , Edited by admin on Sat Jun 26 13:02:54 UTC 2021
PRIMARY
DRUG BANK
DB14513
Created by admin on Sat Jun 26 13:02:54 UTC 2021 , Edited by admin on Sat Jun 26 13:02:54 UTC 2021
PRIMARY
CAS
7439-95-4
Created by admin on Sat Jun 26 13:02:54 UTC 2021 , Edited by admin on Sat Jun 26 13:02:54 UTC 2021
PRIMARY
MERCK INDEX
M6987
Created by admin on Sat Jun 26 13:02:54 UTC 2021 , Edited by admin on Sat Jun 26 13:02:54 UTC 2021
PRIMARY Merck Index
ECHA (EC/EINECS)
231-104-6
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PRIMARY
EPA CompTox
7439-95-4
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PRIMARY
CFR
21 CFR 862.1495
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PRIMARY
NCI_THESAURUS
C68264
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PRIMARY
MESH
D008274
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PRIMARY
RXCUI
6574
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PRIMARY RxNorm
EVMPD
SUB14407MIG
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PRIMARY
NCI_THESAURUS
C1505
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CONCEPT Dietary Supplement
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
Nutritional value per 100 g (3.5 oz) - 21 mg (6%)
Related Record Type Details
ACTIVE MOIETY