U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}
Status:
US Approved OTC
Source:
21 CFR 344.1 otic:earwax removal aid carbamide peroxide 6.5% (in anhydrous glycerin)
Source URL:
First marketed in 1921
Source:
Hydrogen Peroxide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Hydrogen peroxide has been used in medicine for more than 100 years. It is known in surgery as a highly useful irrigation solution by virtue of both its hemostatic and its antimicrobial effects. Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis). This product works by releasing oxygen when it is applied to the affected area. The release of oxygen causes foaming, which helps to remove dead skin and clean the area. Hydrogen peroxide is a strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
Sodium is the primary cation (positive ion) in extracellular fluids in animals and humans. Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste. " Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Carbon tetrachloride, also called tetrachloromethane, a colourless, dense, highly toxic, volatile, nonflammable liquid possessing a characteristic odour and belonging to the family of organic halogen compounds, used principally in the manufacture of dichlorodifluoromethane. Carbon tetrachloride is commonly used as a chemical intermediate, solvent, and dry-cleaning fluid. It was widely used as a cleaning fluid. Carbon tetrachloride was also used in fire extinguishers and as a fumigant to kill insects in grain. Human exposure to carbon tetrachloride from occupational or environmental sources is low and unlikely to produce acute kidney toxicity. Carbon tetrachloride is a manufactured chemical and does not occur naturally in the environment.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

p-Toluenesulfonic acid (PTSA) is an organic compound with the formula CH3C6H4SO3H. An aromatic sulfonic acid, often used as a strong acid catalyst. p-Toluenesulfonic acid monohydrate has been used as a reducing agent for the reductive amination of ketones and aldehydes. In the presence of p-Toluenesulfonic acid monohydrate novel deazaflavin-cholestane hybrid compounds have been synthesized in a condensation reaction. 2-Phenylethyl alpha-glucoside has also been synthesized in the presence of p-Toluenesulfonic acid monohydrate. p-toluenesulfonic acid esters, are a common class of reagents used in the pharmaceutical industry as alkylating agents, catalysts, and in purification steps of the chemical synthesis of a drug substance.
Brucine is an alkaloid resembling strychnine but it is much less potent than strychnine. Brucine was first discovered in 1819 by Pelletier and Caventou in the bark of the Strychnos nux vomica tree. Brucine causes paralysis of the peripheral nerve endings and produces violent convulsions. Since brucine is a large chiral molecule, it has been used as an enantioselective recognition agent using in chiral resolution. While brucine has been shown to have good anti-tumor effects, on both hepatocellular carcinoma and breast cancer, its narrow therapeutic window has limited its use as a treatment for cancer. Brucine is also used in traditional Chinese medicine as an anti-inflammatory and analgesic agent, as well as in some Ayurveda and homeopathy drugs. Like strychnine, brucine also functions as antagonist at the glycine receptor and paralyzes the inhibitory neurons
Status:
US Previously Marketed
Source:
Diluted Hydrobromic Acid U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Diluted Hydrobromic Acid U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Hydrobromic acid is a useful reagent for generating organobromine compounds. It was shown that hydrobromic acid could initiate or exacerbate inflammatory pulmonary disease.
Status:
US Previously Marketed
Source:
Potassium Sulphocyanate
(1921)
Source URL:
First marketed in 1921
Source:
Potassium Sulphocyanate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US
Source:
Canada:PALLADIUM
Source URL:
First approved in 2015

Class (Stereo):
CHEMICAL (ACHIRAL)

Palladium is a rare and lustrous silvery-white metal. Palladium has the lowest melting point and is the least dense of platinum group metals. The primary use for palladium is in catalytic converters for the automotive industry. Palladium-based complexes are appealing alternative metal-based drugs because of significant similarities regarding structure and coordination chemistry with the platinum agents. Research suggests that one of the big reasons for the negative side effects of most anti-cancer drugs could be the use of the metal platinum as the core element in most of them. There is, however, evidence that the side-effects could be minimised by replacing it with a close metal relative, palladium. Currently, palladium complexes are being studied for their anti-cancer activity. Palladium nanoparticles (PdNPs) have attracted wide attention owing to their multifaceted utility in catalysis, sensors, and biomedical applications. Their therapeutic spectrum includes anticancer, antiviral, antibacterial, antifungal, antidiabetic, antioxidant potential which rationalizes the exploration of diverse physical, chemical, and biological routes for fabrication.