U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula H2O2
Molecular Weight 34.0147
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROGEN PEROXIDE

SMILES

OO

InChI

InChIKey=MHAJPDPJQMAIIY-UHFFFAOYSA-N
InChI=1S/H2O2/c1-2/h1-2H

HIDE SMILES / InChI
Hydrogen peroxide has been used in medicine for more than 100 years. It is known in surgery as a highly useful irrigation solution by virtue of both its hemostatic and its antimicrobial effects. Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis). This product works by releasing oxygen when it is applied to the affected area. The release of oxygen causes foaming, which helps to remove dead skin and clean the area. Hydrogen peroxide is a strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
4.54000000000000004 null [pEC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ESKATA

Approved Use

ESKATA is indicated for the treatment of seborrheic keratoses that are raised.

Launch Date

1513123200000
Preventing
Hydrogen Peroxide Solution

Approved Use

Uses of Hydrogen Peroxide Solution: It is used to prevent skin infections. It is used to help get rid of phlegm or mucus or help with a sore mouth.
Primary
Hydrogen Peroxide Solution

Approved Use

Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis).

Launch Date

410140800000
PubMed

PubMed

TitleDatePubMed
Simultaneous measurement of ERK, p38, and JNK MAP kinase cascades in vascular smooth muscle cells.
2000 Sep-Oct
Mitochondrial-derived oxidants and quartz activation of chemokine gene expression.
2001
Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death.
2001 Apr 19
Manganese superoxide dismutase signals matrix metalloproteinase expression via H2O2-dependent ERK1/2 activation.
2001 Apr 27
Reactive carbonyl formation by oxidative and non-oxidative pathways.
2001 Aug 1
Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin.
2001 Aug 1
DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin.
2001 Dec
Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation.
2001 Dec
NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells.
2001 Dec 1
Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite.
2001 Dec 21
Chromium chloride inhibits oxidative stress and TNF-alpha secretion caused by exposure to high glucose in cultured U937 monocytes.
2001 Dec 7
Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism.
2001 Feb
Down-regulation of catalase gene expression in the doxorubicin-resistant AML subline AML-2/DX100.
2001 Feb 16
Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant.
2001 Jun
Repression of phenobarbital-dependent CYP2B1 mRNA induction by reactive oxygen species in primary rat hepatocyte cultures.
2001 Jun
Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells.
2001 Jun 15
Human alveolar macrophages and granulocyte-macrophage colony-stimulating factor-induced monocyte-derived macrophages are resistant to H2O2 via their high basal and inducible levels of catalase activity.
2001 Jun 29
IL-4 gene expression up-regulated by mercury in rat mast cells: a role of oxidant stress in IL-4 transcription.
2001 Mar
Variants of peroxiredoxins expression in response to hydroperoxide stress.
2001 Mar 15
Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins.
2001 May
The influence of oxidative stress on catalase and MnSOD gene transcription in astrocytes.
2001 May 4
p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line.
2001 Nov
Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein.
2001 Nov 30
Phosphorylation is involved in the activation of metal-regulatory transcription factor 1 in response to metal ions.
2001 Nov 9
Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells.
2001 Nov-Dec
Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells.
2001 Oct
Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.
2001 Oct
Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death.
2001 Oct 9
Role of reactive oxygen species and NAD(P)H oxidase in alpha(1)-adrenoceptor signaling in adult rat cardiac myocytes.
2002 Apr
Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells.
2002 Aug 1
An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.
2002 Aug 15
Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth.
2002 Feb 15
Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts.
2002 Jul
Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929.
2002 Jul 15
D-penicillamine cooperates with copper sulfate to enhance the surface expression of functional Fas antigen in rheumatoid synovial fibroblasts via the generation of hydrogen peroxide.
2002 Jul-Aug
Menadione biphasically controls JNK-linked cell death in leukemia Jurkat T cells.
2002 Jun
Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors.
2002 Jun
Reversible inactivation of the tumor suppressor PTEN by H2O2.
2002 Jun 7
Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase.
2002 Mar
Glucose-6-phosphate dehydrogenase: the key to sex-related xenobiotic toxicity in hepatocytes of European flounder (Platichthys flesus L.)?
2002 Mar
Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway.
2002 May
Expression of rat liver glutathione-S-transferase GSTA5 in cell lines provides increased resistance to alkylating agents and toxic aldehydes.
2002 May 20
Doxorubicin-induced apoptosis: implications in cardiotoxicity.
2002 May-Jun
Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species.
2002 Oct
Reactive oxygen species stimulated human hepatoma cell proliferation via cross-talk between PI3-K/PKB and JNK signaling pathways.
2002 Oct 15
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
2002 Oct 25
Is calcineurin a peroxide-specific sensor in T-lymphocytes?
2002 Sep
Iron augments stage-I and stage-II tumor promotion in murine skin.
2002 Sep 26
Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium.
2002 Sep 30
The antioxidant cocktail effective microorganism X (EM-X) inhibits oxidant-induced interleukin-8 release and the peroxidation of phospholipids in vitro.
2002 Sep 6
Patents

Sample Use Guides

Topical solution: 40% (w/w) hydrogen peroxide. Apply 4 times, approximately 1 minute apart, to the
Route of Administration: Topical
Hydrogen peroxide (H2O2, 100-500 uM) caused a concentration-dependent decrease in the activity of recombinant mouse 3-MST enzyme. In mitochondria isolated from murine hepatoma cells, H2O2 (50-500 uM) caused a concentration-dependent decrease in production of H2S from 3-MP. In cultured murine hepatoma cells H2O2, (3-100 uM), did not result in overall cytotoxicity, but caused a partial decrease in basal oxygen consumption and respiratory reserve rapacity. The positive bioenergetic effect of 3-MP (100-300 nM) was completely abolished by pre-treatment of the cells with H2O2 (50 uM).
Name Type Language
HYDROGEN PEROXIDE
FCC   GREEN BOOK   HSDB   II   INCI   MART.   MI   USP   VANDF   WHO-DD  
INCI  
Official Name English
HYDROGEN PEROXIDE [USP]
Common Name English
HYROGEN PEROXIDE
Common Name English
HYDROGEN PEROXIDE [WHO-DD]
Common Name English
OXYDOL
Brand Name English
NSC-19892
Code English
HYDROGEN PEROXIDE [FCC]
Common Name English
HYDROGEN PEROXIDE [MI]
Common Name English
ESKATA
Brand Name English
OXYDOL [JAN]
Common Name English
HYDROGEN PEROXIDE [GREEN BOOK]
Common Name English
HYDROGEN PEROXIDE SOLUTION
Common Name English
HYDROGEN PEROXIDE [HSDB]
Common Name English
HYDROGEN PEROXIDE [IARC]
Common Name English
HYDROGEN PEROXIDE [II]
Common Name English
HYDROGEN PEROXIDE IN AQUEOUS SOLUTION
Common Name English
HYDROGEN PEROXIDE [MART.]
Common Name English
HYDROGEN PEROXIDE [ORANGE BOOK]
Common Name English
HYDROGEN PEROXIDE [VANDF]
Common Name English
HYDROGEN PEROXIDE [INCI]
Common Name English
A-101
Code English
Classification Tree Code System Code
Food Contact Sustance Notif, (FCN No.) FCN NO. 140
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 880
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
CFR 21 CFR 310.534
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 1035
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 908
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 1247
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 724
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 1094
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 728
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 670
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
WHO-VATC QA01AB02
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
WHO-ATC A01AB02
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
WHO-ATC D11AX25
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
NCI_THESAURUS C28394
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 951
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 641
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 1132
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 295
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 1144
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 1025
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 447
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 1081
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 801
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
EPA PESTICIDE CODE 595
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 699
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 691
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
WHO-ATC D08AX01
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 625
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 323
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 911
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 1089
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 993
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 561
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
CFR 21 CFR 184.1366
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
WHO-ATC S02AA06
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 1093
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 1096
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 879
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 921
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
DSLD 3327 (Number of products:1)
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
WHO-VATC QD08AX01
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 887
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 1236
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
WHO-VATC QS02AA06
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
CFR 21 CFR 173.356
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
Code System Code Type Description
EVMPD
SUB14135MIG
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY
ChEMBL
CHEMBL71595
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY
WIKIPEDIA
HYDROGEN PEROXIDE
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY
CAS
8007-30-5
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
ALTERNATIVE
ECHA (EC/EINECS)
231-765-0
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY
CAS
7722-84-1
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY
MERCK INDEX
M6105
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY Merck Index
MESH
D006861
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY
FDA UNII
BBX060AN9V
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY
NCI_THESAURUS
C28156
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY
DRUG CENTRAL
3281
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY
PUBCHEM
784
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY
DRUG BANK
DB11091
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY
RXCUI
5499
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY RxNorm
HSDB
547
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY
EPA CompTox
7722-84-1
Created by admin on Sat Jun 26 08:14:15 UTC 2021 , Edited by admin on Sat Jun 26 08:14:15 UTC 2021
PRIMARY