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Details

Stereochemistry ACHIRAL
Molecular Formula H2O2
Molecular Weight 34.0147
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Hydrogen peroxide

SMILES

OO

InChI

InChIKey=MHAJPDPJQMAIIY-UHFFFAOYSA-N
InChI=1S/H2O2/c1-2/h1-2H

HIDE SMILES / InChI

Description

Hydrogen peroxide has been used in medicine for more than 100 years. It is known in surgery as a highly useful irrigation solution by virtue of both its hemostatic and its antimicrobial effects. Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis). This product works by releasing oxygen when it is applied to the affected area. The release of oxygen causes foaming, which helps to remove dead skin and clean the area. Hydrogen peroxide is a strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.

CNS Activity

Originator

Approval Year

1921
1447
Targets

Targets

Primary TargetPharmacologyConditionPotency
Modulator
817
Agonist
2637
 4.54 null [pEC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8307
ESKATA

Approved Use

ESKATA is indicated for the treatment of seborrheic keratoses that are raised.

Launch Date

1.51312322E12
Preventing
Approved
8307
Hydrogen Peroxide Solution

Approved Use

Uses of Hydrogen Peroxide Solution: It is used to prevent skin infections. It is used to help get rid of phlegm or mucus or help with a sore mouth.
Primary
Approved
8307
Hydrogen Peroxide Solution

Approved Use

Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis).

Launch Date

4.10140803E11
PubMed

PubMed

TitleDatePubMed
Evidence for the involvement of the fatty acid and peroxisomal beta-oxidation pathways in the inhibition by dehydroepiandrosterone (DHEA) and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benz(a)anthracene (BA) of cytochrome P4501B1 (CYP1B1) in mouse embryo fibroblasts (C3H10T1/2 cells).
1999 Aug
Rotenone and pyruvate prevent the tert-butylhydroperoxide-induced necrosis of U937 cells and allow them to proliferate.
1999 Aug 20
Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity.
1999 Oct 1
Inhibition of glomerular cell apoptosis by heparin.
1999 Sep
Stable overexpression of manganese superoxide dismutase in mitochondria identifies hydrogen peroxide as a major oxidant in the AP-1-mediated induction of matrix-degrading metalloprotease-1.
1999 Sep 3
Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils.
2000 Feb 1
Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function.
2000 Jun 15
Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis.
2000 Jun 8
Role of antioxidant systems in human androgen-independent prostate cancer cells.
2000 May 1
Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis.
2000 Oct 20
Roles of oxygen radical production and lipid peroxidation in the cytotoxicity of cephaloridine on cultured renal epithelial cells (LLC-PK1).
2000 Sep
Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways.
2000 Sep
Simultaneous measurement of ERK, p38, and JNK MAP kinase cascades in vascular smooth muscle cells.
2000 Sep-Oct
Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death.
2001 Apr 19
Manganese superoxide dismutase signals matrix metalloproteinase expression via H2O2-dependent ERK1/2 activation.
2001 Apr 27
Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin.
2001 Aug 1
Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation.
2001 Dec
Chromium chloride inhibits oxidative stress and TNF-alpha secretion caused by exposure to high glucose in cultured U937 monocytes.
2001 Dec 7
Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells.
2001 Jul 6
Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant.
2001 Jun
Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells.
2001 Jun 15
Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins.
2001 May
The influence of oxidative stress on catalase and MnSOD gene transcription in astrocytes.
2001 May 4
p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line.
2001 Nov
Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.
2001 Oct
Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts.
2002 Jul
Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929.
2002 Jul 15
Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors.
2002 Jun
Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway.
2002 May
Expression of rat liver glutathione-S-transferase GSTA5 in cell lines provides increased resistance to alkylating agents and toxic aldehydes.
2002 May 20
The antioxidant cocktail effective microorganism X (EM-X) inhibits oxidant-induced interleukin-8 release and the peroxidation of phospholipids in vitro.
2002 Sep 6
Patents

Patents

03931169
4
03932472
92
03947406
30
03952001
6
03985796
4
04007276
7
04012430
5
04022769
29
04023926
4
04028278
4
04036988
4
04039685
4
04042773
4
04062875
4
04064135
4
04083983
6
04098816
16
04100280
5
04115584
8
04148918
8
04153716
4
04163789
5
04168379
7
04170704
9
04172945
10
04180518
6
20040162406
4
6639031
4

Sample Use Guides

In Vivo Use Guide
Topical solution: 40% (w/w) hydrogen peroxide. Apply 4 times, approximately 1 minute apart, to the targeted lesion(s) during a single in-office treatment session.
Route of Administration: Topical
In Vitro Use Guide
Hydrogen peroxide (H2O2, 100-500 uM) caused a concentration-dependent decrease in the activity of recombinant mouse 3-MST enzyme. In mitochondria isolated from murine hepatoma cells, H2O2 (50-500 uM) caused a concentration-dependent decrease in production of H2S from 3-MP. In cultured murine hepatoma cells H2O2, (3-100 uM), did not result in overall cytotoxicity, but caused a partial decrease in basal oxygen consumption and respiratory reserve rapacity. The positive bioenergetic effect of 3-MP (100-300 nM) was completely abolished by pre-treatment of the cells with H2O2 (50 uM).
Name Type Language
Hydrogen peroxide
FCC   GREEN BOOK   HSDB   II   INCI   MART.   MI   USP   VANDF   WHO-DD  
INCI  
Official Name English
HYROGEN PEROXIDE
Common Name English
OXYDOL
Brand Name English
NSC-19892
Code English
HYDROGEN PEROXIDE [FCC]
Common Name English
HYDROGEN PEROXIDE [MI]
Common Name English
ESKATA
Brand Name English
OXYDOL [JAN]
Common Name English
HYDROGEN PEROXIDE [GREEN BOOK]
Common Name English
HYDROGEN PEROXIDE SOLUTION
Common Name English
HYDROGEN PEROXIDE [HSDB]
Common Name English
HYDROGEN PEROXIDE [IARC]
Common Name English
HYDROGEN PEROXIDE [II]
Common Name English
HYDROGEN PEROXIDE IN AQUEOUS SOLUTION
Common Name English
HYDROGEN PEROXIDE [MART.]
Common Name English
HYDROGEN PEROXIDE [ORANGE BOOK]
Common Name English
HYDROGEN PEROXIDE [VANDF]
Common Name English
Hydrogen peroxide [WHO-DD]
Common Name English
HYDROGEN PEROXIDE [INCI]
Common Name English
A-101
Code English
HYDROGEN PEROXIDE [USP IMPURITY]
Common Name English
Classification Tree Code System Code
Food Contact Sustance Notif, (FCN No.) FCN NO. 140
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 880
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
CFR 21 CFR 310.534
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 1035
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 908
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 1247
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 724
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 1094
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 728
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 670
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
WHO-VATC QA01AB02
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
WHO-ATC A01AB02
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
WHO-ATC D11AX25
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
NCI_THESAURUS C28394
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 951
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 641
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 1132
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 295
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 1144
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 1025
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 447
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 1081
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 801
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
EPA PESTICIDE CODE 595
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 699
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 691
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
WHO-ATC D08AX01
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 625
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 323
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 911
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 1089
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 993
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 561
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
CFR 21 CFR 184.1366
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
WHO-ATC S02AA06
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 1093
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 1096
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 879
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 921
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
DSLD 3327 (Number of products:1)
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
WHO-VATC QD08AX01
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 887
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Food Contact Sustance Notif, (FCN No.) FCN NO. 1236
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
WHO-VATC QS02AA06
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
CFR 21 CFR 173.356
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
Code System Code Type Description
EVMPD
SUB14135MIG
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
ChEMBL
CHEMBL71595
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
WIKIPEDIA
HYDROGEN PEROXIDE
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
DAILYMED
BBX060AN9V
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
CAS
8007-30-5
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
ALTERNATIVE
ECHA (EC/EINECS)
231-765-0
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
CAS
7722-84-1
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
CHEBI
16240
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
MERCK INDEX
M6105
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY Merck Index
MESH
D006861
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
FDA UNII
BBX060AN9V
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
GRAS Notification (GRN No.)
14
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
NCI_THESAURUS
C28156
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
DRUG CENTRAL
3281
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
PUBCHEM
784
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
DRUG BANK
DB11091
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
NSC
19892
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
RXCUI
5499
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY RxNorm
HSDB
547
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
EPA CompTox
DTXSID2020715
Created by admin on Fri Dec 16 20:18:45 UTC 2022 , Edited by admin on Fri Dec 16 20:18:45 UTC 2022
PRIMARY
NIH
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