VITAMIN A

Description

Retonol, also known as Vitamin A1, is a vitamin found in food and used as a dietary supplement. It is used to treat and prevent vitamin A deficiency. It is also used to prevent further issues in those who have measles. Retinol is used as a metabolic precursor of retinoic acid to treat skin-related conditions, such as cellulite, skin aging, photodamage.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Superoxide dismutase 4	Activator 1,430
Lecithin retinol acyltransferase 4	Substrate 661
Retinol dehydrogenase 12 4	Substrate 661
11-cis retinol dehydrogenase 5	Substrate 661

Conditions

Condition	Modality	Highest Phase	Product
Vitamin A deficiency 4	Preventing	Phase III 656	Unknown
Maternal morbidity 4	Preventing	Phase III 656	Unknown
Maternal mortality 4	Preventing	Phase III 656	Unknown
Vitamin A deficiency 4	Primary	Approved 8,429	AQUASOL A
Measles 4	Palliative	Approved 8,429	AQUASOL A
Skin photodamage 4	Primary	Phase II 1,132	Unknown
Skin aging 5	Primary	Phase IV 63	Unknown

PubMed

Show entries

Title	Date	PubMed
[Review of acute hydrocephalus caused by administration of vitamin A in massive doses in nursing infants; based on 100 cases].	1957 Feb	13410607
Vitamin A induced benign intracranial hypertension.	1976 Feb	130200
[Renal tubular failure after treatment with high dose of vitamin A (author's transl)].	1976 Feb 6	1248399
Bilateral transverse sinus obstruction in benign intracranial hypertension due to hypervitaminosis A.	1978 Aug	151668
McCollum Award Lecture, 1992: vitamin A absorption, transport, cellular uptake, and storage.	1992 Oct	1414975

Showing 1 to 5 of 31 entries

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Patents

Sample Use Guides

In Vivo Use Guide

Weekly single oral dose 7000 micrograms

Route of Administration: Oral

In Vitro Use Guide

The role of vitamin A (2.72 μM/7 ml culture), a naturally occurring antioxidant upon arsenic-induced genotoxicity; with respect to chromosomal aberrations (structural and numerical) and micronuclei. Whole blood cultures set for 72 h were exposed to test chemicals for a period of 24 h ahead of harvesting. Arsenic concentrations tested in the present study are 0.36, 0.72 and 1.4 μM/7 ml culture. Mitomycin C (MMC), the direct acting mutagen was used as positive control.