DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8801161
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8801161
Retonol, also known as Vitamin A1, is a vitamin found in food and used as a dietary supplement. It is used to treat and prevent vitamin A deficiency. It is also used to prevent further issues in those who have measles. Retinol is used as a metabolic precursor of retinoic acid to treat skin-related conditions, such as cellulite, skin aging, photodamage.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2354 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30972178 |
|||
Target ID: O95237 Gene ID: 9227.0 Gene Symbol: LRAT Target Organism: Homo sapiens (Human) |
|||
Target ID: Q96NR8 Gene ID: 145226.0 Gene Symbol: RDH12 Target Organism: Homo sapiens (Human) Sources: https://www.drugbank.ca/drugs/DB00162 |
|||
Target ID: Q92781 Gene ID: 5959.0 Gene Symbol: RDH5 Target Organism: Homo sapiens (Human) Sources: https://www.drugbank.ca/drugs/DB00162 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Preventing | Unknown Approved UseUnknown |
|||
Preventing | Unknown Approved UseUnknown |
|||
Preventing | Unknown Approved UseUnknown |
|||
Primary | AQUASOL A Approved UseUsed to treat and prevent symptoms of vitamin A deficiency such as xerophthalmia and night blindness. Used as a dietary supplement to prevent vitamin A deficiency in patients with GI diseases (e.g., malabsorption syndromes) and those with abnormal storage and transport of vitamin A (e.g., abetalipoproteinemia, protein deficiency, diabetes mellitus, hyperthyroidism, fever, liver disease, cystic fibrosis with hepatic involvement). Launch Date1949 |
|||
Palliative | AQUASOL A Approved UseChildren with severe measles have been found to have low serum concentrations of vitamin A; WHO and AAP recommend that vitamin A supplements be given to all children with acute measles, regardless of their country of residence. Launch Date1949 |
|||
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
[Renal tubular failure after treatment with high dose of vitamin A (author's transl)]. | 1976 Feb 6 |
|
Effect of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-(4-(5-Nitro-2-furyl)-2-thiazolyl)formamide. | 1976 Jul |
|
Fruit and fertility in San Juan de la Manguana. | 1995 |
|
Vitamin A toxicity secondary to excessive intake of yellow-green vegetables, liver and laver. | 1999 Jul |
|
Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells. | 1999 Nov 9 |
|
Hepatic hyper-vitaminosis A: importance of retinyl ester level determination. | 2000 Mar |
|
Effects of beta-carotene and vitamin A on oval cell proliferation and connexin 43 expression during hepatic differentiation in the rat(1). | 2001 Dec |
|
Use of vitamin supplements and cataract: the Blue Mountains Eye Study. | 2001 Jul |
|
Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up-regulated by retinoids and is involved in the metabolism of retinol. | 2001 Jun 29 |
|
Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients. | 2001 Nov |
|
Restoring effects of vitamin A on surfactant synthesis in nitrofen-induced congenital diaphragmatic hernia in rats. | 2001 Sep 15 |
|
The anemia of vitamin A deficiency: epidemiology and pathogenesis. | 2002 Apr |
|
[Treatment of acne with consequences -- pseudotumor cerebri due to hypervitaminosis A]. | 2002 Jan 9 |
|
Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation. | 2002 Nov |
|
Retinoids regulate the repairing process of the podocytes in puromycin aminonucleoside-induced nephrotic rats. | 2003 Apr |
|
PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. | 2003 Feb |
|
Impact of 'Mad Cow Disease' publicity on trends in meat and total vitamin A consumption in Geneva between 1993 and 2000. | 2003 Jan |
|
Redistribution of vitamin A after iron supplementation in Indonesian infants. | 2003 Mar |
|
Vitamin A deficiency leads to increased cell proliferation in olfactory epithelium of mature rats. | 2003 Mar |
|
Pharmacology of all-trans-retinoic acid in children with acute promyelocytic leukemia. | 2003 May |
|
Dietary vitamin A intakes of Filipino elders with adequate or low liver vitamin A concentrations as assessed by the deuterated-retinol-dilution method: implications for dietary requirements. | 2004 Apr |
|
Modulation of resistin expression by retinoic acid and vitamin A status. | 2004 Apr |
|
A palmitoylation switch mechanism in the regulation of the visual cycle. | 2004 Jun 11 |
|
Safety and efficacy of dose-intensive oral vitamin A in subjects with sun-damaged skin. | 2004 Mar 15 |
|
Use of the deuterated-retinol-dilution technique to monitor the vitamin A status of Nicaraguan schoolchildren 1 y after initiation of the Nicaraguan national program of sugar fortification with vitamin A. | 2004 Nov |
|
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A metabolism in mice. | 2005 |
|
Fortification of maize meal improved the nutritional status of 1-3-year-old African children. | 2005 Aug |
|
Effects of prenatal vitamins A, E, and C on the hypoplastic hearts of fetal rats with diaphragmatic hernia. | 2005 Aug |
|
Retinal degeneration associated with RDH12 mutations results from decreased 11-cis retinal synthesis due to disruption of the visual cycle. | 2005 Dec 15 |
|
Phospho-STAT5 accumulation in nuclear fractions from vitamin A-deficient rat liver. | 2005 Jul 4 |
|
Serum and CSF vitamin A concentrations in idiopathic intracranial hypertension. | 2005 Jun 14 |
|
Inhibitory effects of vitamin A on TCDD-induced cytochrome P-450 1A1 enzyme activity and expression. | 2005 May |
|
Vitamin A regulation of BMP4 expression in the male germ line. | 2005 Oct 1 |
|
Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle. | 2005 Sep 20 |
|
Transmembrane protein GDE2 induces motor neuron differentiation in vivo. | 2005 Sep 30 |
|
Hypervitaminosis A resulting in DNA aberration in fetal transgenic mice (Muta Mouse). | 2005 Sep 5 |
|
Comparative ligand-binding analysis of ten human lipocalins. | 2006 Feb |
|
Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells. | 2006 Feb |
|
Role of retinoic acid receptors alpha1 and gamma in the response of murine limbs to retinol in vitro. | 2006 Jan |
|
Expression of Connexin 43 in the hearts of rat embryos exposed to nitrofen and effects of vitamin A on it. | 2006 Jan |
|
Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis. | 2006 Jan |
|
Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption. | 2006 Mar |
Patents
Sample Use Guides
The role of vitamin A (2.72 μM/7 ml culture), a naturally occurring antioxidant upon arsenic-induced genotoxicity; with respect to chromosomal aberrations (structural and numerical) and micronuclei. Whole blood cultures set for 72 h were exposed to test chemicals for a period of 24 h ahead of harvesting. Arsenic concentrations tested in the present study are 0.36, 0.72 and 1.4 μM/7 ml culture. Mitomycin C (MMC), the direct acting mutagen was used as positive control.
Substance Class |
Mixture
Created
by
admin
on
Edited
Fri Dec 15 16:19:51 GMT 2023
by
admin
on
Fri Dec 15 16:19:51 GMT 2023
|
Record UNII |
81G40H8B0T
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NDF-RT |
N0000006269
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
CFR |
21 CFR 862.1805
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
NDF-RT |
N0000006269
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
WHO-ATC |
V04CB01
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
DSLD |
3315 (Number of products:1063)
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
NDF-RT |
N0000006269
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
NDF-RT |
N0000006269
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
NDF-RT |
N0000006269
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
CFR |
21 CFR 101.78
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
FDA ORPHAN DRUG |
546216
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
CFR |
21 CFR 184.1930
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
WHO-VATC |
QV04CB01
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
DSLD |
2698 (Number of products:2377)
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
LIVERTOX |
NBK548165
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
NDF-RT |
N0000175950
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
||
|
DSLD |
201 (Number of products:4964)
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
234-328-2
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
DTXSID301014459
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
DB00162
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
SUB16102MIG
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
Vitamin A
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
CHEMBL986
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
81G40H8B0T
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
11103-57-4
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
17616
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
11246
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | RxNorm | ||
|
VITAMIN A
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
SUB05791MIG
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
C938
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
D014801
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
81G40H8B0T
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
17336
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | |||
|
VITAMIN A
Created by
admin on Fri Dec 15 16:19:51 GMT 2023 , Edited by admin on Fri Dec 15 16:19:51 GMT 2023
|
PRIMARY | Description: A yellow to brownish yellow, oily liquid.Solubility: Practically insoluble in water; soluble or partly soluble in dehydrated ethanol R; miscible with organic solvents.Category: Vitamin.Storage: The oily form of Retinol concentrate should be kept in a well-closed and well-filled container, protected from light. Oncethe container has been opened its contents should be used as soon as possible; any part of the contents not used at once shouldbe protected by an atmosphere of inert gas.Labelling: The designation on the container should state the name of the retinol ester or esters, and their quantities expressed asthe content of vitamin A in International Units (IU) per gram, whether any stabilizing agents are added and their quantities, as wellas the method of restoring the solution if partial crystallization has occurred.Additional information: Even in the absence of light the oily form of Retinol concentrate is gradually degraded on exposure to ahumid atmosphere, the decomposition being faster at higher temperatures.Partial crystallization may occur in concentrated solutions and upon refrigeration. |
One of these components may be present:
Related Record | Type | Details | ||
---|---|---|---|---|
|
PARENT -> CONSTITUENT ALWAYS PRESENT | |||
|
PARENT -> CONSTITUENT ALWAYS PRESENT | |||
|
DERIVATIVE -> PARENT |
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT | |||
|
PARENT -> CONSTITUENT ALWAYS PRESENT | |||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |