DescriptionCurator's Comment:: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8801161
Curator's Comment:: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8801161
Retonol, also known as Vitamin A1, is a vitamin found in food and used as a dietary supplement. It is used to treat and prevent vitamin A deficiency. It is also used to prevent further issues in those who have measles. Retinol is used as a metabolic precursor of retinoic acid to treat skin-related conditions, such as cellulite, skin aging, photodamage.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2354 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30972178 |
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Target ID: O95237 Gene ID: 9227.0 Gene Symbol: LRAT Target Organism: Homo sapiens (Human) |
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Target ID: Q96NR8 Gene ID: 145226.0 Gene Symbol: RDH12 Target Organism: Homo sapiens (Human) Sources: https://www.drugbank.ca/drugs/DB00162 |
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Target ID: Q92781 Gene ID: 5959.0 Gene Symbol: RDH5 Target Organism: Homo sapiens (Human) Sources: https://www.drugbank.ca/drugs/DB00162 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Unknown Approved UseUnknown |
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Preventing | Unknown Approved UseUnknown |
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Preventing | Unknown Approved UseUnknown |
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Primary | AQUASOL A Approved UseUsed to treat and prevent symptoms of vitamin A deficiency such as xerophthalmia and night blindness. Used as a dietary supplement to prevent vitamin A deficiency in patients with GI diseases (e.g., malabsorption syndromes) and those with abnormal storage and transport of vitamin A (e.g., abetalipoproteinemia, protein deficiency, diabetes mellitus, hyperthyroidism, fever, liver disease, cystic fibrosis with hepatic involvement). Launch Date-6.5093763E11 |
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Palliative | AQUASOL A Approved UseChildren with severe measles have been found to have low serum concentrations of vitamin A; WHO and AAP recommend that vitamin A supplements be given to all children with acute measles, regardless of their country of residence. Launch Date-6.5093763E11 |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Retinol-induced mdr1 and mdr3 modulation in cultured rat Sertoli cells is attenuated by free radical scavengers. | 2004 |
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Vitamin A prevents high fat diet-induced ACF development and modifies the pattern of expression of peroxisome proliferator and retinoic acid receptor m-RNA. | 2004 |
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Dietary vitamin A intakes of Filipino elders with adequate or low liver vitamin A concentrations as assessed by the deuterated-retinol-dilution method: implications for dietary requirements. | 2004 Apr |
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Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. | 2004 Aug |
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Vitamin A regulates proliferation and apoptosis of human T- and B-cells. | 2004 Dec |
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Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor. | 2004 Dec |
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A palmitoylation switch mechanism in the regulation of the visual cycle. | 2004 Jun 11 |
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Safety and efficacy of dose-intensive oral vitamin A in subjects with sun-damaged skin. | 2004 Mar 15 |
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Use of the deuterated-retinol-dilution technique to monitor the vitamin A status of Nicaraguan schoolchildren 1 y after initiation of the Nicaraguan national program of sugar fortification with vitamin A. | 2004 Nov |
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Age differences in vitamin A intake among Canadian Inuit. | 2004 Nov-Dec |
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Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A metabolism in mice. | 2005 |
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Alcohol, vitamin A, and cancer. | 2005 Apr |
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Brain tissue fragments in the amniotic fluid of rats with neural tube defect. | 2005 Apr |
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What is the safe dose of vitamin A in children with measles? | 2005 Apr |
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Retinoid receptor mRNA expression profiles in human bladder cancer specimens. | 2005 Apr |
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Fortification of maize meal improved the nutritional status of 1-3-year-old African children. | 2005 Aug |
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Effects of prenatal vitamins A, E, and C on the hypoplastic hearts of fetal rats with diaphragmatic hernia. | 2005 Aug |
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beta-cryptoxanthin stimulates cell differentiation and mineralization in osteoblastic MC3T3-E1 cells. | 2005 Aug 15 |
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Vitamin A status in mice affects the histone code of the phosphoenolpyruvate carboxykinase gene in liver. | 2005 Dec |
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Retinal degeneration associated with RDH12 mutations results from decreased 11-cis retinal synthesis due to disruption of the visual cycle. | 2005 Dec 15 |
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Phospho-STAT5 accumulation in nuclear fractions from vitamin A-deficient rat liver. | 2005 Jul 4 |
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Effect of vitamin A content in cafeteria diet on the expression of nuclear receptors in rat subcutaneous adipose tissue. | 2005 Jun |
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Serum and CSF vitamin A concentrations in idiopathic intracranial hypertension. | 2005 Jun 14 |
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Vitamin A supplementation for extremely low birth weight infants: outcome at 18 to 22 months. | 2005 Mar |
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Inhibitory effects of vitamin A on TCDD-induced cytochrome P-450 1A1 enzyme activity and expression. | 2005 May |
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Megalin-mediated reuptake of retinol in the kidneys of mice is essential for vitamin A homeostasis. | 2005 Nov |
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Expression of nuclear receptor and target genes in liver and intestine of neonatal calves fed colostrum and vitamin A. | 2005 Nov |
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Retinol inhibits the growth of all-trans-retinoic acid-sensitive and all-trans-retinoic acid-resistant colon cancer cells through a retinoic acid receptor-independent mechanism. | 2005 Nov 1 |
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Development of a versatile reporter assay for studies of retinol uptake and metabolism in vivo. | 2005 Nov 1 |
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Retinoid metabolism during development of liver cirrhosis. | 2005 Nov 15 |
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Vitamin A supplementation induces adipose tissue loss through apoptosis in lean but not in obese rats of the WNIN/Ob strain. | 2005 Oct |
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Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells. | 2005 Oct |
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Vitamin A regulation of BMP4 expression in the male germ line. | 2005 Oct 1 |
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Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1. | 2005 Oct 15 |
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Expression of keratinocyte transglutaminase in cornea of vitamin A-deficient rats. | 2005 Sep |
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Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle. | 2005 Sep 20 |
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Transmembrane protein GDE2 induces motor neuron differentiation in vivo. | 2005 Sep 30 |
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Effects of nitrofen and vitamins A, C and E on maturation of cultured human H441 pneumocytes. | 2006 |
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The effect of vitamin A on CCl4-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study. | 2006 |
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Vitamin A improves Pax3 expression that is decreased in the heart of rats with experimental diaphragmatic hernia. | 2006 Feb |
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The acute and chronic toxic effects of vitamin A. | 2006 Feb |
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Comparative ligand-binding analysis of ten human lipocalins. | 2006 Feb |
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Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells. | 2006 Feb |
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Retinoic acid regulates sex-specific timing of meiotic initiation in mice. | 2006 Feb 21 |
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RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle. | 2006 Feb 3 |
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Role of retinoic acid receptors alpha1 and gamma in the response of murine limbs to retinol in vitro. | 2006 Jan |
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Renal pathology and retinol status in multiple myeloma patients. | 2006 Jan |
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Expression of Connexin 43 in the hearts of rat embryos exposed to nitrofen and effects of vitamin A on it. | 2006 Jan |
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Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption. | 2006 Mar |
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Retinol palmitate protects against myocardial ischemia/reperfusion injury via reducing oxidative stress and inhibiting apoptosis. | 2019 |
Patents
Sample Use Guides
The role of vitamin A (2.72 μM/7 ml culture), a naturally occurring antioxidant upon arsenic-induced genotoxicity; with respect to chromosomal aberrations (structural and numerical) and micronuclei. Whole blood cultures set for 72 h were exposed to test chemicals for a period of 24 h ahead of harvesting. Arsenic concentrations tested in the present study are 0.36, 0.72 and 1.4 μM/7 ml culture. Mitomycin C (MMC), the direct acting mutagen was used as positive control.
Substance Class |
Mixture
Created
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Fri Jun 25 21:08:49 UTC 2021
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Fri Jun 25 21:08:49 UTC 2021
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Record UNII |
81G40H8B0T
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NDF-RT |
N0000006269
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CFR |
21 CFR 862.1805
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NDF-RT |
N0000006269
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WHO-ATC |
V04CB01
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DSLD |
3315 (Number of products:1063)
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NDF-RT |
N0000006269
Created by
admin on Fri Jun 25 21:08:49 UTC 2021 , Edited by admin on Fri Jun 25 21:08:49 UTC 2021
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NDF-RT |
N0000006269
Created by
admin on Fri Jun 25 21:08:49 UTC 2021 , Edited by admin on Fri Jun 25 21:08:49 UTC 2021
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NDF-RT |
N0000006269
Created by
admin on Fri Jun 25 21:08:49 UTC 2021 , Edited by admin on Fri Jun 25 21:08:49 UTC 2021
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CFR |
21 CFR 101.78
Created by
admin on Fri Jun 25 21:08:49 UTC 2021 , Edited by admin on Fri Jun 25 21:08:49 UTC 2021
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FDA ORPHAN DRUG |
546216
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CFR |
21 CFR 184.1930
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WHO-VATC |
QV04CB01
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DSLD |
2698 (Number of products:2377)
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LIVERTOX |
1033
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NDF-RT |
N0000175950
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DSLD |
201 (Number of products:4964)
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Code System | Code | Type | Description | ||
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234-328-2
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DB00162
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SUB16102MIG
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Vitamin A
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CHEMBL986
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11103-57-4
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11246
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VITAMIN A
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SUB05791MIG
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C938
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PRIMARY | |||
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D014801
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81G40H8B0T
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VITAMIN A
Created by
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PRIMARY | Description: A yellow to brownish yellow, oily liquid.Solubility: Practically insoluble in water; soluble or partly soluble in dehydrated ethanol R; miscible with organic solvents.Category: Vitamin.Storage: The oily form of Retinol concentrate should be kept in a well-closed and well-filled container, protected from light. Oncethe container has been opened its contents should be used as soon as possible; any part of the contents not used at once shouldbe protected by an atmosphere of inert gas.Labelling: The designation on the container should state the name of the retinol ester or esters, and their quantities expressed asthe content of vitamin A in International Units (IU) per gram, whether any stabilizing agents are added and their quantities, as wellas the method of restoring the solution if partial crystallization has occurred.Additional information: Even in the absence of light the oily form of Retinol concentrate is gradually degraded on exposure to ahumid atmosphere, the decomposition being faster at higher temperatures.Partial crystallization may occur in concentrated solutions and upon refrigeration. |
One of these components may be present:
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PARENT -> CONSTITUENT ALWAYS PRESENT | |||
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PARENT -> CONSTITUENT ALWAYS PRESENT | |||
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PARENT -> CONSTITUENT ALWAYS PRESENT | |||
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PARENT -> CONSTITUENT ALWAYS PRESENT | |||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
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ACTIVE MOIETY |