VITAMIN A PALMITATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C36H60O2
Molecular Weight	524.8604
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	4
Charge	0

SHOW SMILES / InChI

SMILES

CCCCCCCCCCCCCCCC(=O)OC\C=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C

InChI

InChIKey=VYGQUTWHTHXGQB-FFHKNEKCSA-N

InChI=1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+

HIDE SMILES / InChI

Molecular Formula	C36H60O2
Molecular Weight	524.8604
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	4
Optical Activity	NONE

Description

Retonol, also known as Vitamin A1, is a vitamin found in food and used as a dietary supplement. It is used to treat and prevent vitamin A deficiency. It is also used to prevent further issues in those who have measles. Retinol is used as a metabolic precursor of retinoic acid to treat skin-related conditions, such as cellulite, skin aging, photodamage.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Superoxide dismutase 4	Activator 1,445
Lecithin retinol acyltransferase 4	Substrate 657
Retinol dehydrogenase 12 4	Substrate 657
11-cis retinol dehydrogenase 5	Substrate 657

Conditions

Condition	Modality	Highest Phase	Product
Vitamin A deficiency 4	Preventing	Phase III 664	Unknown
Maternal morbidity 4	Preventing	Phase III 664	Unknown
Maternal mortality 4	Preventing	Phase III 664	Unknown
Vitamin A deficiency 4	Primary	Approved 8,548	AQUASOL A
Measles 4	Palliative	Approved 8,548	AQUASOL A
Skin photodamage 4	Primary	Phase II 1,145	Unknown
Skin aging 5	Primary	Phase IV 63	Unknown

PubMed

Show entries

Title	Date	PubMed
Fruit and fertility in San Juan de la Manguana.	1995	12290005
Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells.	1999 Nov 9	10557354
Low serum retinol levels are associated with hepatocellular carcinoma in patients with chronic liver disease.	2000 Oct	11012474
Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up-regulated by retinoids and is involved in the metabolism of retinol.	2001 Jun 29	11304534
Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.	2001 Nov	11792017

Showing 1 to 5 of 15 entries

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Patents

Sample Use Guides

In Vivo Use Guide

Weekly single oral dose 7000 micrograms

Route of Administration: Oral

In Vitro Use Guide

The role of vitamin A (2.72 μM/7 ml culture), a naturally occurring antioxidant upon arsenic-induced genotoxicity; with respect to chromosomal aberrations (structural and numerical) and micronuclei. Whole blood cultures set for 72 h were exposed to test chemicals for a period of 24 h ahead of harvesting. Arsenic concentrations tested in the present study are 0.36, 0.72 and 1.4 μM/7 ml culture. Mitomycin C (MMC), the direct acting mutagen was used as positive control.