U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Showing 1 - 10 of 11 results

Status:
US Approved Rx (2020)
First approved in 1989

Class (Stereo):
CHEMICAL (ACHIRAL)



Clomipramine is an antidepressant drug which was approved by FDA for the treatment of Obsessive-Compulsive Disorder. The exact mechanism of its action is unknown, however it is supposed that it may exert its effect by inhibiting serotonin reuptake.
Status:
US Approved Rx (2013)
First approved in 1987

Class (Stereo):
CHEMICAL (RACEMIC)



Fluoxetine hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). Fluoxetine is a racemic mixture of the R- and S- enantiomers and are of equivalent pharmacologic activity. Despite d...
Status:
US Approved Rx (2007)
First approved in 1967

Class (Stereo):
CHEMICAL (ACHIRAL)



Haloperidol is a phenyl-piperidinyl-butyrophenone that is used primarily to treat schizophrenia and other psychoses. It is also used in schizoaffective disorder, delusional disorders, ballism, and Tourette syndrome (a drug of choice) and occasionally...
Status:
US Approved Rx (2008)
First approved in 1964

Class (Stereo):
CHEMICAL (ACHIRAL)



Valproic acid (VPA; valproate; di-n-propylacetic acid, DPA; 2-propylpentanoic acid, or 2-propylvaleric acid) was first synthesized in 1882, by Burton. FDA approved valproic acid for the treatment of manic episodes associated with bipolar disorder, fo...
Status:
US Approved Rx (2022)
First approved in 1963

Class (Stereo):
CHEMICAL (ACHIRAL)



Diazepam is a benzodiazepine first discovered at Hoffman-La Roche in the late 1950s. Diazepam was approved by FDA for the treatment of anxiety disorders as well as for such conditions as skeletal muscle spasm, alcohol withdrawal syndrom and convulsion...
Status:
US Approved Rx (1987)
First approved in 1961

Class (Stereo):
CHEMICAL (ACHIRAL)



Amitriptyline is a derivative of dibenzocycloheptadiene and a tricyclic antidepressant (TCA) and is mainly used to treat symptoms of depression. It works on the central nervous system (CNS) by inhibiting the membrane pump mechanism responsible for up...
Status:
US Approved Rx (1996)
First approved in 1959

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of behaviorial complications in patients with mental r...
Status:
US Approved Rx (2021)
First approved in 1954

Class (Stereo):
CHEMICAL (ACHIRAL)



Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Chlorpromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on...
Status:
US Approved Rx (2018)
First approved in 1947

Class (Stereo):
CHEMICAL (RACEMIC)



Methadone, sold under the brand names Dolophine among others, is an synthetic opioid that is used as the hydrochloride to treat pain and as maintenance therapy or to help with detoxification in people with opioid dependence. Methadone hydrochloride i...
Status:
US Approved Rx (2022)
First approved in 1968

Class (Stereo):
CHEMICAL (ACHIRAL)



Carbamazepine is an analgesic, anti-epileptic agent that is FDA approved for the treatment of epilepsy, trigeminal neuralgia. It appears to act by reducing polysynaptic responses and blocking the post-tetanic potentiation. It depresses thalamic poten...

Showing 1 - 10 of 11 results