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Details

Stereochemistry ACHIRAL
Molecular Formula C19H23ClN2
Molecular Weight 314.853
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOMIPRAMINE

SMILES

CN(C)CCCN1c2ccccc2CCc3ccc(cc31)Cl

InChI

InChIKey=GDLIGKIOYRNHDA-UHFFFAOYSA-N
InChI=1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3

HIDE SMILES / InChI
Clomipramine is an antidepressant drug which was approved by FDA for the treatment of Obsessive-Compulsive Disorder. The exact mechanism of its action is unknown, however it is supposed that it may exert its effect by inhibiting serotonin reuptake.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ANAFRANIL

Approved Use

Clomipramine hydrochloride capsules USP are indicated for the treatment of obsessions and compulsions in patients with Obsessive-Compulsive Disorder (OCD).

Launch Date

630892800000
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
31.3 ng/mL
50 mg single, oral
dose: 50 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CLOMIPRAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
92 ng/mL
50 mg single, oral
dose: 50 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CLOMIPRAMINE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
736 ng × h/mL
50 mg single, oral
dose: 50 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CLOMIPRAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
23.5 h
50 mg single, oral
dose: 50 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CLOMIPRAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
300 mg 1 times / day multiple, oral
Recommended
Dose: 300 mg, 1 times / day
Route: oral
Route: multiple
Dose: 300 mg, 1 times / day
Sources:
unhealthy, 35
Health Status: unhealthy
Age Group: 35
Sex: M+F
Sources:
Other AEs: Dry mouth, Constipation...
Other AEs:
Dry mouth (42.9%)
Constipation (25%)
Somnolence (24.1%)
Tremor (22.3%)
Dizziness (17.9%)
Nausea (16.1%)
Sweating (13.4%)
Asthenia (9.8%)
Insomnia (8%)
Abdominal pain (3.6%)
Sources:
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Other AEs: Somnolence, Tremor...
Other AEs:
Somnolence (46%)
Tremor (33%)
Dizziness (41%)
Headache (28%)
Insomnia (11%)
Nervousness (4%)
Myoclonus (2%)
Paresthesia (2%)
Memory impairment (7%)
Anxiety (2%)
Twitching (4%)
Hypertonia (2%)
Sleep disorder (9%)
Confusion (2%)
Depersonalization (2%)
Irritability (2%)
Panic reaction (2%)
Aggressive reaction (2%)
Paresis (2%)
Sweating increased (9%)
Rash (4%)
Pruritus (2%)
Skin odor abnormal (2%)
Dry mouth (63%)
Constipation (22%)
Nausea (9%)
Dyspepsia (13%)
Diarrhea (7%)
Anorexia (22%)
Abdominal pain (13%)
Vomiting (7%)
Eructation (2%)
Ulcerative stomatitis (2%)
Fatigue (35%)
Weight increase (2%)
Flushing (7%)
Hot flushes (2%)
Chest pain (7%)
Fever (2%)
Allergy (7%)
Pain (4%)
Weight decrease (7%)
Otitis media (4%)
Asthenia (2%)
Halitosis (2%)
Postural hypotension (4%)
Palpitation (4%)
Tachycardia (2%)
Syncope (2%)
Rhinitis (7%)
Sinusitis (2%)
Coughing (4%)
Bronchospasm (7%)
Dyspnea (2%)
Laryngitis (2%)
Micturition disorder (4%)
Urinary retention (7%)
Abnormal vision (7%)
Taste perversion (4%)
Tinnitus (4%)
Anisocoria (2%)
Blepharospasm (2%)
Eye allergy (2%)
Disorder vestibular (2%)
Muscle weakness (2%)
Anemia (2%)
Sources:
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Other AEs: Somnolence, Tremor...
Other AEs:
Somnolence (54%)
Tremor (54%)
Dizziness (54%)
Headache (52%)
Insomnia (25%)
Influence on libido (21%)
Nervousness (18%)
Myoclonus (13%)
Increased appetite (11%)
Paresthesia (9%)
Memory impairment (9%)
Anxiety (9%)
Twitching (7%)
Concentration impaired (5%)
Depression (5%)
Hypertonia (4%)
Sleep disorder (4%)
Psychosomatic disease (3%)
Yawning (3%)
Confusion (3%)
Speech disorder (3%)
Dreaming abnormal (3%)
Agitation (3%)
Migraine (3%)
Depersonalization (2%)
Irritability (2%)
Emotional lability (2%)
Panic reaction (1%)
Sweating increased (29%)
Rash (8%)
Pruritus (6%)
Dermatitis (2%)
Acne (2%)
Dry skin (2%)
Urticaria (1%)
Dry mouth (84%)
Constipation (47%)
Nausea (33%)
Dyspepsia (22%)
Diarrhea (13%)
Anorexia (12%)
Abdominal pain (11%)
Vomiting (7%)
Flatulence (6%)
Tooth disorder (5%)
Gastrointestinal disorder (2%)
Dysphagia (2%)
Esophagitis (1%)
Fatigue (39%)
Weight increase (18%)
Flushing (8%)
Hot flushes (5%)
Chest pain (4%)
Fever (4%)
Allergy (3%)
Pain (3%)
Localised edema (2%)
Chills (2%)
Postural hypotension (6%)
Palpitation (4%)
Tachycardia (4%)
Pharyngitis (14%)
Rhinitis (12%)
Sinusitis (6%)
Coughing (6%)
Bronchospasm (2%)
Epistaxis (2%)
Micturition disorder (14%)
Urinary tract infection (6%)
Micturition frequency (5%)
Urinary retention (2%)
Dysuria (2%)
Cystitis (2%)
Abnormal vision (18%)
Taste perversion (8%)
Tinnitus (6%)
Lacrimation abnormal (3%)
Mydriasis (2%)
Conjunctivitis (1%)
Myalgia (13%)
Back pain (6%)
Arthralgia (3%)
Muscle weakness (1%)
Purpura (3%)
Thirst (2%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Sweating 13.4%
300 mg 1 times / day multiple, oral
Recommended
Dose: 300 mg, 1 times / day
Route: oral
Route: multiple
Dose: 300 mg, 1 times / day
Sources:
unhealthy, 35
Health Status: unhealthy
Age Group: 35
Sex: M+F
Sources:
Nausea 16.1%
300 mg 1 times / day multiple, oral
Recommended
Dose: 300 mg, 1 times / day
Route: oral
Route: multiple
Dose: 300 mg, 1 times / day
Sources:
unhealthy, 35
Health Status: unhealthy
Age Group: 35
Sex: M+F
Sources:
Dizziness 17.9%
300 mg 1 times / day multiple, oral
Recommended
Dose: 300 mg, 1 times / day
Route: oral
Route: multiple
Dose: 300 mg, 1 times / day
Sources:
unhealthy, 35
Health Status: unhealthy
Age Group: 35
Sex: M+F
Sources:
Tremor 22.3%
300 mg 1 times / day multiple, oral
Recommended
Dose: 300 mg, 1 times / day
Route: oral
Route: multiple
Dose: 300 mg, 1 times / day
Sources:
unhealthy, 35
Health Status: unhealthy
Age Group: 35
Sex: M+F
Sources:
Somnolence 24.1%
300 mg 1 times / day multiple, oral
Recommended
Dose: 300 mg, 1 times / day
Route: oral
Route: multiple
Dose: 300 mg, 1 times / day
Sources:
unhealthy, 35
Health Status: unhealthy
Age Group: 35
Sex: M+F
Sources:
Constipation 25%
300 mg 1 times / day multiple, oral
Recommended
Dose: 300 mg, 1 times / day
Route: oral
Route: multiple
Dose: 300 mg, 1 times / day
Sources:
unhealthy, 35
Health Status: unhealthy
Age Group: 35
Sex: M+F
Sources:
Abdominal pain 3.6%
300 mg 1 times / day multiple, oral
Recommended
Dose: 300 mg, 1 times / day
Route: oral
Route: multiple
Dose: 300 mg, 1 times / day
Sources:
unhealthy, 35
Health Status: unhealthy
Age Group: 35
Sex: M+F
Sources:
Dry mouth 42.9%
300 mg 1 times / day multiple, oral
Recommended
Dose: 300 mg, 1 times / day
Route: oral
Route: multiple
Dose: 300 mg, 1 times / day
Sources:
unhealthy, 35
Health Status: unhealthy
Age Group: 35
Sex: M+F
Sources:
Insomnia 8%
300 mg 1 times / day multiple, oral
Recommended
Dose: 300 mg, 1 times / day
Route: oral
Route: multiple
Dose: 300 mg, 1 times / day
Sources:
unhealthy, 35
Health Status: unhealthy
Age Group: 35
Sex: M+F
Sources:
Asthenia 9.8%
300 mg 1 times / day multiple, oral
Recommended
Dose: 300 mg, 1 times / day
Route: oral
Route: multiple
Dose: 300 mg, 1 times / day
Sources:
unhealthy, 35
Health Status: unhealthy
Age Group: 35
Sex: M+F
Sources:
Insomnia 11%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Abdominal pain 13%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Dyspepsia 13%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Aggressive reaction 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Anemia 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Anisocoria 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Anxiety 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Asthenia 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Blepharospasm 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Confusion 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Depersonalization 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Disorder vestibular 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Dyspnea 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Eructation 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Eye allergy 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Fever 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Halitosis 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Hot flushes 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Hypertonia 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Irritability 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Laryngitis 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Muscle weakness 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Myoclonus 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Panic reaction 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Paresis 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Paresthesia 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Pruritus 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Sinusitis 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Skin odor abnormal 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Syncope 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Tachycardia 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Ulcerative stomatitis 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Weight increase 2%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Anorexia 22%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Constipation 22%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Headache 28%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Tremor 33%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Fatigue 35%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Coughing 4%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Micturition disorder 4%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Nervousness 4%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Otitis media 4%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Pain 4%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Palpitation 4%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Postural hypotension 4%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Rash 4%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Taste perversion 4%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Tinnitus 4%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Twitching 4%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Dizziness 41%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Somnolence 46%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Dry mouth 63%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Abnormal vision 7%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Allergy 7%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Bronchospasm 7%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Chest pain 7%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Diarrhea 7%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Flushing 7%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Memory impairment 7%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Rhinitis 7%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Urinary retention 7%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Vomiting 7%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Weight decrease 7%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Nausea 9%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Sleep disorder 9%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Sweating increased 9%
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy, Children and Adolescents
Health Status: unhealthy
Age Group: Children and Adolescents
Sex: M+F
Sources:
Conjunctivitis 1%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Esophagitis 1%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Muscle weakness 1%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Panic reaction 1%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Urticaria 1%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Abdominal pain 11%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Increased appetite 11%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Anorexia 12%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Rhinitis 12%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Diarrhea 13%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Myalgia 13%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Myoclonus 13%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Micturition disorder 14%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Pharyngitis 14%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Abnormal vision 18%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Nervousness 18%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Weight increase 18%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Acne 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Bronchospasm 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Chills 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Cystitis 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Depersonalization 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Dermatitis 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Dry skin 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Dysphagia 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Dysuria 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Emotional lability 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Epistaxis 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Gastrointestinal disorder 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Irritability 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Localised edema 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Mydriasis 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Thirst 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Urinary retention 2%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Influence on libido 21%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Dyspepsia 22%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Insomnia 25%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Sweating increased 29%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Agitation 3%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Allergy 3%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Arthralgia 3%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Confusion 3%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Dreaming abnormal 3%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Lacrimation abnormal 3%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Migraine 3%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Pain 3%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Psychosomatic disease 3%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Purpura 3%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Speech disorder 3%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Yawning 3%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Nausea 33%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Fatigue 39%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Chest pain 4%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Fever 4%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Hypertonia 4%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Palpitation 4%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Sleep disorder 4%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Tachycardia 4%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Constipation 47%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Concentration impaired 5%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Depression 5%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Hot flushes 5%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Micturition frequency 5%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Tooth disorder 5%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Headache 52%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Dizziness 54%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Somnolence 54%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Tremor 54%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Back pain 6%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Coughing 6%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Flatulence 6%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Postural hypotension 6%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Pruritus 6%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Sinusitis 6%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Tinnitus 6%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Urinary tract infection 6%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Twitching 7%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Vomiting 7%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Flushing 8%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Rash 8%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Taste perversion 8%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Dry mouth 84%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Anxiety 9%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Memory impairment 9%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Paresthesia 9%
250 mg 1 times / day multiple, oral
Recommended
Dose: 250 mg, 1 times / day
Route: oral
Route: multiple
Dose: 250 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M+F
Sources:
Overview

Overview

OverviewOther

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes
yes
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
major
minor
no
no
no
no
yes
yes
yes
yes (pharmacogenomic study)
Comment: administration of clomipramine to a CYP2C19 intermediate metabolizer resulted in elevated serum trough concentrations
yes
yes (pharmacogenomic study)
Comment: administration of clomipramine to a CYP2D6 intermediate metabolizer resulted in elevated serum trough concentrations
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Depressive reactions in the course of clomipramine therapy used in the treatment of obsessional conditions.
1975
Effect of drugs influencing central serotonergic mechanisms on haloperidol-induced catalepsy.
1979 Mar 29
The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation.
1999
[The influence of clomipramine-induced mania on rapid cycling affective disorder].
1999 Dec 1
Side effects as predictors of drug response in obsessive-compulsive disorder.
1999 Oct
Seizures caused by possible interaction between olanzapine and clomipramine.
2000 Apr
Serotonin and dopamine antagonism in obsessive-compulsive disorder: effect of atypical antipsychotic drugs.
2000 Nov
Availability of learned helplessness test as a model of depression compared to a forced swimming test in rats.
2001
Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder.
2001
Pharmacological characterization of the serotonin transporter in young and elderly subjects.
2001
Psychogenic excoriation. Clinical features, proposed diagnostic criteria, epidemiology and approaches to treatment.
2001
Simultaneous analysis of clozapine, clomipramine and their metabolites by reversed-phase liquid chromatography.
2001 Apr
[Current drug treatment. Effects of antidepressive agents in nervous and stress-related disorders].
2001 Apr 2
Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study.
2001 Aug
S33005, a novel ligand at both serotonin and norepinephrine transporters: II. Behavioral profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.
2001 Aug
S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.
2001 Aug
Altered dendritic spine density in animal models of depression and in response to antidepressant treatment.
2001 Dec 1
Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation.
2001 Feb
Therapeutic effects and long-term efficacy of antidepressant medication for persons with developmental disabilities. Behavioral assessment in two cases of treatment-resistant aggression and self-injury.
2001 Jan
Pharmacological characterization and visualization of the glial serotonin transporter.
2001 Jul
The critical window of brain development from susceptive to insusceptive. Effects of clomipramine neonatal treatment on sexual behavior.
2001 Jul 23
Neurobiology and clinical pharmacology of obsessive-compulsive disorder.
2001 Jul-Aug
Pharmacological manipulations of the extinction process of fear-induced ultrasonic vocalization in rats.
2001 Jun
Placebo affects the performance of rats in models of depression: is it a good control for behavioral experiments?
2001 Jun
Comparison of peripheral inhibitory effects of clomipramine with selective serotonin re-uptake inhibitors on contraction of vas deferens: in vitro and in vivo studies.
2001 Jun
The serotonergic 5-HT(2C) agonist m-chlorophenylpiperazine increases weight-supported locomotion without development of tolerance in rats with spinal transections.
2001 Jun
The exploding head syndrome.
2001 Jun
Cortical 5-HT(1A) receptor downregulation by antidepressants in rat brain.
2001 Jun
Pharmacological treatment of childhood obsessive-compulsive disorder: from theory to practice.
2001 Mar
Antinociceptive effect of clomipramine in monoarthritic rats as revealed by the paw pressure test and the C-fiber-evoked reflex.
2001 Mar 23
Long-term effects of clomipramine and fluoxetine on dorsal periaqueductal grey-evoked innate defensive behaviours of the rat.
2001 May
Olanzapine augmentation of serotonin uptake inhibitors in obsessive-compulsive disorder: an open study.
2001 May
A meta-analysis of the efficacy and tolerability of paroxetine versus tricyclic antidepressants in the treatment of major depression.
2001 May
Assessment of the serotonin and norepinephrine reuptake blocking properties of duloxetine in healthy subjects.
2001 May
[Value of fluoxetine in obsessive-compulsive disorder in the adult: review of the literature].
2001 May-Jun
Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters.
2001 Nov
Clinical predictors of drug response in obsessive-compulsive disorder.
2001 Oct
Clomipramine discontinuation-emergent dystonia.
2001 Oct
Obsessive-compulsive symptoms during treatment with clozapine in a patient with schizophrenia.
2001 Oct
Spontaneous reports on drug-induced pancreatitis in Denmark from 1968 to 1999.
2001 Sep
Taijin kyofusho: a form of social anxiety disorder that responds to serotonin reuptake inhibitors?
2001 Sep
Comment: serotonin syndrome and 5-HT2A antagonism.
2001 Sep
Differential time-course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors.
2001 Sep 15
High-performance liquid chromatographic method to screen and quantitate seven selective serotonin reuptake inhibitors in human serum.
2001 Sep 25
Effects of clomipramine on Trypanosoma cruzi infection in mice.
2001 Sep-Oct
Diurnal profile of melatonin secretion in the acute phase of major depression and in remission.
2001 Sep-Oct
Patents

Sample Use Guides

Adults: Treatment should be initiated at a dosage of 25 mg daily and gradually increased, as tolerated, to approximately 100 mg during the first 2 weeks. During initial titration, the drug should be given in divided doses with meals to reduce gastrointestinal side effects. Thereafter, the dosage may be increased gradually over the next several weeks, up to a maximum of 250 mg daily.
Route of Administration: Oral
In Vitro Use Guide
The effect of clomipramine, at concentrations of 10(-7)M to 10(-4)M, was studied in vitro on the uptake of 5-hydroxytryptamine and dopamine uptake in human platelet-rich plasma.
Name Type Language
CLOMIPRAMINE
HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
NSC-169865
Code English
CHLORIMIPRAMINE
Common Name English
CLOMIPRAMINE [MI]
Common Name English
ANAPRAMINE
Common Name English
CLOMIPRAMINE [WHO-DD]
Common Name English
CLOMIPRAMINE [INN]
Common Name English
3-CHLORO-5-(3-(DIMETHYLAMINO)PROPYL)-10,11-DIHYDRO-5H-DIBENZ(B,F)AZEPINE
Systematic Name English
5H-DIBENZ(B,F)AZEPINE-5-PROPANAMINE, 3-CHLORO-10,11-DIHYDRO-N,N-DIMETHYL-
Systematic Name English
CLOMICALM
Brand Name English
3-CHLORO-IMINODIBENZYL
Common Name English
CLOMIPRAMINE [HSDB]
Common Name English
CLOMIPRAMINE [VANDF]
Common Name English
CLOMIPRAMINE [EMA EPAR: VETERINARY]
Common Name English
Classification Tree Code System Code
WHO-ESSENTIAL MEDICINES LIST 24.4
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
NDF-RT N0000175752
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
WHO-ATC N06AA04
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
CFR 21 CFR 520.455
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
NCI_THESAURUS C94727
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
EMA VETERINARY ASSESSMENT REPORTS CLOMICALM (AUTHORISED)
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
WHO-VATC QN06AA04
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
LIVERTOX 223
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C61608
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
RXCUI
2597
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY RxNorm
EPA CompTox
303-49-1
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
EVMPD
SUB06725MIG
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
LACTMED
Clomipramine
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
ChEMBL
CHEMBL415
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
DRUG CENTRAL
701
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
INN
2238
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
MERCK INDEX
M3648
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY Merck Index
WIKIPEDIA
CLOMIPRAMINE
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
MESH
D002997
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
DRUG BANK
DB01242
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
HSDB
7746
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
ECHA (EC/EINECS)
206-144-2
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
PUBCHEM
2801
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
IUPHAR
2398
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
FDA UNII
NUV44L116D
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY
CAS
303-49-1
Created by admin on Sat Jun 26 12:54:47 UTC 2021 , Edited by admin on Sat Jun 26 12:54:47 UTC 2021
PRIMARY