DESMETHYLCLOMIPRAMINE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H21ClN2
Molecular Weight	300.8263
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNCCCN1c2ccccc2CCc3ccc(cc31)Cl

InChI

InChIKey=VPIXQGUBUKFLRF-UHFFFAOYSA-N

InChI=1S/C18H21ClN2/c1-20-11-4-12-21-17-6-3-2-5-14(17)7-8-15-9-10-16(19)13-18(15)21/h2-3,5-6,9-10,13,20H,4,7-8,11-12H2,1H3

HIDE SMILES / InChI

Molecular Formula	C18H21ClN2
Molecular Weight	300.8263
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
serotonin uptake 19 Target ID: GO:0051610 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7393826	Inhibitor 7728
dopamine uptake 13 Target ID: GO:0090494 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7393826	Inhibitor 7728

PubMed

Title	Date	PubMed
Orthostatic side effects of clomipramine and citalopram during treatment for depression.	1985	3929308
Delirious episodes induced by intravenous administration of clomipramine associated with an acute increase in its plasma concentrations.	2000 Dec	11145466

Patents

Substance Class	Chemical Created by `admin` on `Sat Jun 26 01:27:58 UTC 2021` Edited by `admin` on `Sat Jun 26 01:27:58 UTC 2021`
Record UNII	01DN47PPQG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DESMETHYLCLOMIPRAMINE

Common Name

English

NORCHLORIMIPRAMINE

Common Name

English

5H-DIBENZ(B,F)AZEPINE-5-PROPANAMINE, 3-CHLORO-10,11-DIHYDRO-N-METHYL-

Systematic Name

English

DESMETHYLCLOMIPRAMINE [WHO-DD]

Common Name

English

GP-38025

Code

English

Code System Code Type Description

CAS

303-48-0

Created by admin on Sat Jun 26 01:27:58 UTC 2021 , Edited by admin on Sat Jun 26 01:27:58 UTC 2021

PRIMARY

FDA UNII

01DN47PPQG

Created by admin on Sat Jun 26 01:27:58 UTC 2021 , Edited by admin on Sat Jun 26 01:27:58 UTC 2021

PRIMARY

EVMPD

SUB195252

Created by admin on Sat Jun 26 01:27:58 UTC 2021 , Edited by admin on Sat Jun 26 01:27:58 UTC 2021

PRIMARY

PUBCHEM

622606

Created by admin on Sat Jun 26 01:27:58 UTC 2021 , Edited by admin on Sat Jun 26 01:27:58 UTC 2021

PRIMARY

Related Record Type Details


					LR0F81F33L

ALDEHYDE OXIDASE

METABOLIC ENZYME -> INHIBITOR

Qualification:

IC50

Amount:

Related Record Type Details


					NUV44L116D

CLOMIPRAMINE

PARENT -> METABOLITE ACTIVE

Interaction Type:

MAJOR