Ioglycamate is triiodocarboxyanilide derivative patented by Schering A.-G. as intravenous cholangiographic X-ray contrast media. Meglumine ioglycamate and was marketed in South Africa in 1976 under brand name Biligram. Ioglycamate is rapidly eliminated from human blood where approximately 95% of the administered dose is bound to the plasma proteins. The mean plasma half-life is 30 minutes. Tbe compound is not metabolised to any great extent but most is eliminated a unchanged molecules with the faeces. In clinical trials good to excellent opacification was achieved in 69% of all patients. A total of 17% of all patients showed side-effects, the majority of which were transient and of a minor nature. Blood pressure and liver function were apparently not affected

Methyl jasmonate (MJ) is a natural cyclopentanone lipid belonging to the jasmonates (JAs) family of plant oxylipin stress hormones (oxygenated fatty acids). Methyl jasmonate is found universally in the plant kingdom and functions to regulate plant growth and development, as well as in stress responses through signal transduction pathways. Methyl jasmonate has recently been found to have anti-cancer activity. MJ (1) arrests cell cycle, inhibiting cell growth and proliferation, (2) causes cell death through the intrinsic/extrinsic proapoptotic, p53-independent apoptotic, and nonapoptotic (necrosis) pathways, (3) detaches hexokinase from the voltage-dependent anion channel, dissociating glycolytic and mitochondrial functions, decreasing the mitochondrial membrane potential, favoring cytochrome c release and ATP depletion, activating pro-apoptotic, and inactivating antiapoptotic proteins, (4) induces reactive oxygen species mediated responses, (5) stimulates MAPK-stress signaling and redifferentiation in leukemia cells, (6) inhibits overexpressed proinflammatory enzymes in cancer cells such as aldo-keto reductase 1 and 5-lipoxygenase, and (7) inhibits cell migration and shows antiangiogenic and antimetastatic activities. Finally, MJ may act as a chemosensitizer to some chemotherapics helping to overcome drug resistant. The complete lack of toxicity to normal cells and the rapidity by which MJ causes damage to cancer cells turn MJ into a promising anticancer agent that can be used alone or in combination with other agents. Methyl jasmonate detached hexokinase 2 from a voltage-dependent anion channel causing a reduction in mitochondrial transmembrane potential that led to the release of cytochrome C and apoptosis inducing factor resulting in intrinsic apoptosis. Blocked adenosine triphosphate synthesis caused by mitochondrial injury hampered oxidative phosphorylation and led to cell necrosis. Methyl jasmonate may be an adjuvant therapy for liver tumors due to its mechanism in cancer cells compared to that in normal cells: The major function is to inhibit glycolysis instead of changing aerobic metabolism.

Indolebutyric acid (IBA) is a plant hormone in the auxin family. IBA promoted plant rooting and used commercially world wide to root many plant species. IBA considered to be toxic to animals and human. IBA demonstrated antineoplastic action in animal model. According to in silico and in vitro study IBA can act as competitive inhibitor to the phospholipase A₂ and may be used as anti inflammatory agent.

Penicillic acid (PA) is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium species showed antibacterial activity against various plant pathogenic bacteria and can be as a lead molecule for the development of synthetic agrochemicals to control plant bacterial diseases. In addition, PA induces single-strand DNA breaks and inhibits DNA synthesis, demonstrating mutagenic and cytotoxic effects. Penicillic acid irreversibly inhibits GDP-mannose dehydrogenase (DMG), an alginate synthesis enzyme, interrupting the committed step in alginate biosynthesis.