Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C24H38O3 |
| Molecular Weight | 374.5567 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@]4([H])CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=O
InChI
InChIKey=KIQFUORWRVZTHT-OPTMKGCMSA-N
InChI=1S/C24H38O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-16,18-21H,4-14H2,1-3H3,(H,26,27)/t15-,16-,18+,19-,20+,21+,23+,24-/m1/s1
| Molecular Formula | C24H38O3 |
| Molecular Weight | 374.5567 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. | 2000 Jun 20 |
|
| The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. | 2001 Mar 13 |
|
| Vitamin D receptor as an intestinal bile acid sensor. | 2002 May 17 |
|
| Specificity of human alcohol dehydrogenase 1C*2 (gamma2gamma2) for steroids and simulation of the uncompetitive inhibition of ethanol metabolism. | 2003 Feb 1 |
|
| Novel pathways of bile acid metabolism involving CYP3A4. | 2005 Feb 21 |
|
| Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts. | 2005 Jul |
|
| Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). | 2005 Sep 30 |
|
| In silico prediction of pregnane X receptor activators by machine learning approaches. | 2007 Jan |
|
| Rapid and drastic induction of CYP3A4 mRNA expression via vitamin D receptor in human intestinal LS180 cells. | 2007 Oct |
|
| Characterization of an oligomeric carbonyl reductase of dog liver: its identity with peroxisomal tetrameric carbonyl reductase. | 2007 Sep |
|
| Biotransformation of lithocholic acid by rat hepatic microsomes: metabolite analysis by liquid chromatography/mass spectrometry. | 2008 Feb |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:30:32 GMT 2023
by
admin
on
Fri Dec 15 18:30:32 GMT 2023
|
| Record UNII |
96JBM35FXF
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
5283906
Created by
admin on Fri Dec 15 18:30:32 GMT 2023 , Edited by admin on Fri Dec 15 18:30:32 GMT 2023
|
PRIMARY | |||
|
17639
Created by
admin on Fri Dec 15 18:30:32 GMT 2023 , Edited by admin on Fri Dec 15 18:30:32 GMT 2023
|
PRIMARY | |||
|
96JBM35FXF
Created by
admin on Fri Dec 15 18:30:32 GMT 2023 , Edited by admin on Fri Dec 15 18:30:32 GMT 2023
|
PRIMARY | |||
|
1553-56-6
Created by
admin on Fri Dec 15 18:30:32 GMT 2023 , Edited by admin on Fri Dec 15 18:30:32 GMT 2023
|
PRIMARY | |||
|
DTXSID60935182
Created by
admin on Fri Dec 15 18:30:32 GMT 2023 , Edited by admin on Fri Dec 15 18:30:32 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> METABOLITE |
IN VITRO
MAJOR
|
