U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 831 - 840 of 11247 results

Status:
Investigational
Source:
INN:metoquizine
Source URL:

Class (Stereo):
CHEMICAL (UNKNOWN)

Metoquizine is a muscarinic acetylcholine receptor antagonist that was used as anti-ulcerative. Information about the current use of this compound is not available.
Status:
Investigational
Source:
NCT01393678: Phase 3 Interventional Completed Chronic Liver Disease
(1997)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

BIPHENYL DIMETHYL DICARBOXYLATE (BDD) under the brand name Nissel is used in the South Corea for the treatment of chronic hepatitis followed by an increase in serum alanine aminotransferase levels continuously. This compound also participated in clinical trials phase III in the patients with chronic liver disease. In addition, the drug was studied in phase III clinical trials after laparoscopic cholecystectomy. The use of BDD in patients with cholecystitis was expected to inhibit elevated liver enzyme levels and to maintain liver function.
Status:
Investigational
Source:
INN:tifencillin
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Thiphencillin is a penicillin analog patented by Abbott Laboratories as an antibacterial agent. Thiphencillin shows potent antibacterial activity against various species and genera of pathogenic bacteria.
Status:
Investigational
Source:
INN:brofoxine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Brofoxine is an anxiolytic, useful in the treatment of psychosis.
Status:
Investigational
Source:
USAN:Aminophenazone
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Ampyrone (4-Aminoantipyrine or AAP) is a metabolite of aminophenazone and is an aromatic substance with analgesic, antipyretic and anti-inflammatory properties. When combined with the antineoplastic agents, ampyrone decreased their genotoxic, mutagenic, apoptotic, and phagocytic effects. However, ampyrone usually produces side effects, such as the risk of agranulocytosis. Although ampyrone is scarcely ever administered as an analgesic because of the potential side effects, as a raw material, it is mostly used to produce ampyrone derivatives, which have better biological activities. In addition, it is used as a reagent for biochemical reactions producing peroxides or phenols and can also be used to detect phenols in the environment. Exposure to ampyrone could induce changes in the enzyme catalase structure and function.
Status:
Investigational
Source:
INN:metalkonium chloride
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Targets:

Metalkonium is an antiseptic and disinfectant.
Status:
Investigational
Source:
Clin Breast Cancer. Jun 2005;6(2):163-8.: Phase 2 Human clinical trial Completed Breast Neoplasms/pathology/surgery
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:temefos
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Temefos (Diphos, Temephos) is an organophosphate larvicide, used to treat water infested with disease-carrying insects including mosquitoes, midges, and black fly larvae. Temefos affects the central nervous system through inhibition of cholinesterase, results in death before reaching the adult stage. Diphos has been used in trials studying the treatment of Plasmodium Falciparum Malaria. Temephos was first registered in the United States in 1965 by American Cyanamid Company for a number of uses including citrus fruits, pet collars, and mosquito control. A Registration Standard was issued in August, 1981. In response to EPA's 1991 Data Call-In, American Cyanamid dropped all uses except the mosquito larvicide use in non-potable waters and requested a low volume minor use waiver for relief from the data requirements associated with that use.
Status:
Designated
Source:
FDA ORPHAN DRUG:906322
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)