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Restrict the search for
dimethyl fumarate
to a specific field?
Class (Stereo):
CHEMICAL (ABSOLUTE)
Metogest, a hormone, is a progesterone receptor agonist. Metogest was used in acne treatment. However, this drug has never been marketed.
Status:
Investigational
Source:
NCT02704390: Phase 3 Interventional Completed Attention Deficit Hyperactivity Disorder
(2016)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Oradon was developed as a mercurial diuretic for oral administration. Information about the current use of this drug is not available.
Status:
Investigational
Source:
INN:dimethadione [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Dimethadione (5,5-dimethyl-2,4-oxazolidinedione) is the N-demethylated metabolite of the anticonvulsant trimethadione. Dimethadione is considered to be a blocker of T-type calcium channel. Dimethadione also inhibits a specific potassium channel (Ikr) in HERG-transfected cells. It exerts teratogenic effect especially congenital heart defects. Dimethadione can be used for the measurement of regional tissue pH using positron emission tomography.
Status:
Investigational
Source:
Avian Pathol. Feb 2008;37(1):45-50.: Not Applicable Veterinary clinical trial Completed Protozoan Infections, Animal/parasitology
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Dimetridazole is an anti-fungal and anti-protozoal drug traditionally used in veterinary for the prevention and treatment of histomoniasis in turkeys, genital trichomoniasis in cattle and hemorrhagic enteritis in pigs. Results from the in vitro and in vivo tests suggested, that dimetridazole was not genotoxic compound, but its use is legally limited, although this compound is still can be found in eggs.
Status:
Investigational
Source:
NCT00848016: Phase 2 Interventional Completed Recurrent Adrenocortical Carcinoma
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Puromycin dihydrochloride belongs to the aminonucleoside family of antibiotics and is isolated from Streptomyces alboniger. Since the partial structure of this antibiotic showed it to be a purine derivative, puromycin was assigned as its generic name. Puromycin is a broad spectrum antibiotic and antibacterial agent. It is active against Gram-positive microorganisms, less active against acid-fast bacilli, and weakly active against Gram-negative microorganisms. It acts very quickly and can kill 99% of the cells within 2 days. It also exhibits antitumor activity in studies on brain tumor cells. Puromycin is a protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3’-terminal end of aminoacyl-tRNA. It has been used to study transcriptional regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation.
Status:
Investigational
Source:
INN:cicloheximide [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Cycloheximide is an antibiotic produced by fermentation culture of Streptomyces griseus, Streptomyces noursei, Streptomyces albulus, Streptomyces naraensis, or other cycloheximide-producing microorganism. It was first discovered by A. Whiffen et al. in 1946. She observed the activity of the compound against the yeasts and it became known as the first antifungal antibiotic. Cycloheximide has been marketed as a plant fungicide for many years and this use continues mainly against fungal diseases of turf and for powdery mildew on roses. More recently, cycloheximide has been recognized and is being developed as an abscission agent for citrus fruits and olives. Due to significant toxic side effects, including DNA damage, teratogenesis, and other reproductive effects, cycloheximide is generally used only in in vitro research applications, and is not suitable for human use as a therapeutic compound. Cycloheximide is an antimitotic and an inhibitor of the synthesis of both DNA and protein.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Epostane (WIN-32729) a pure competitive inhibitor of 3-beta-hydroxysteroid dehydrogenase. Epostane blocks progesterone synthesis during the luteal phase and in pregnancy in women and has strong anti-steroidogenic effect in endocrine tissues. Epostane is an abortifacient agent in early human pregnancy. It inhibits ovarian follicular steroidogenesis and ovulation.
Class (Stereo):
CHEMICAL (ACHIRAL)
Oxagrelate (also known as EG626) is an inhibitor of cAMP phosphodiesterase and lead to the platelet aggregation inhibition. Oxagrelate was studied as a smooth muscle relaxant. Information about the further development of this drug is not available.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Toquizine is an anticholinergic agent. It was used as an antiulcer agent.
