OXAGRELATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H16N2O4
Molecular Weight	276.2878
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=C(C)C2=C(C=C1C)C(CO)=NNC2=O

InChI

InChIKey=DUQOOLBWGUKRAJ-UHFFFAOYSA-N

InChI=1S/C14H16N2O4/c1-4-20-14(19)11-7(2)5-9-10(6-17)15-16-13(18)12(9)8(11)3/h5,17H,4,6H2,1-3H3,(H,16,18)

HIDE SMILES / InChI

Molecular Formula	C14H16N2O4
Molecular Weight	276.2878
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1554521 | https://www.ncbi.nlm.nih.gov/pubmed/6205194

Oxagrelate (also known as EG626) is an inhibitor of cAMP phosphodiesterase and lead to the platelet aggregation inhibition. Oxagrelate was studied as a smooth muscle relaxant. Information about the further development of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Long-term treatment of amyotrophic lateral sclerosis with phthalazinol.	1992	1554521
Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences.	1987-07-15	2821650
Murine tumor-induced platelet aggregation and coagulation: mechanisms, inhibitors, and species differences.	1987-04-01	3590114
Inhibition of human and rat platelet aggregation by extracts of Mo-er (Auricularia auricula).	1982-10-29	6983740

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:46:00 GMT 2025` Edited by `admin` on `Mon Mar 31 17:46:00 GMT 2025`
Record UNII	V17MYO89WO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OXAGRELATE

Official Name

English

NSC-305351

Preferred Name

English

oxagrelate [INN]

Common Name

English

6-PHTHALAZINECARBOXYLIC ACID, 3,4-DIHYDRO-1-(HYDROXYMETHYL)-5,7-DIMETHYL-4-OXO-, ETHYL ESTER

Common Name

English

SC-32840

Code

English

Ethyl 3,4-dihydro-1-(hydroxymethyl)-5,7-dimethyl-4-oxo-6-phthalazinecarboxylate

Systematic Name

English

OXAGRELATE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C744