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Details

Stereochemistry ACHIRAL
Molecular Formula C14H16N2O4
Molecular Weight 276.2878
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXAGRELATE

SMILES

CCOC(=O)C1=C(C)C=C2C(CO)=NNC(=O)C2=C1C

InChI

InChIKey=DUQOOLBWGUKRAJ-UHFFFAOYSA-N
InChI=1S/C14H16N2O4/c1-4-20-14(19)11-7(2)5-9-10(6-17)15-16-13(18)12(9)8(11)3/h5,17H,4,6H2,1-3H3,(H,16,18)

HIDE SMILES / InChI

Molecular Formula C14H16N2O4
Molecular Weight 276.2878
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Oxagrelate (also known as EG626) is an inhibitor of cAMP phosphodiesterase and lead to the platelet aggregation inhibition. Oxagrelate was studied as a smooth muscle relaxant. Information about the further development of this drug is not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Inhibition of human and rat platelet aggregation by extracts of Mo-er (Auricularia auricula).
1982 Oct 29
Murine tumor-induced platelet aggregation and coagulation: mechanisms, inhibitors, and species differences.
1987 Apr 1
Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences.
1987 Jul 15
Long-term treatment of amyotrophic lateral sclerosis with phthalazinol.
1992
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:05:18 UTC 2023
Edited
by admin
on Fri Dec 15 15:05:18 UTC 2023
Record UNII
V17MYO89WO
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OXAGRELATE
INN   USAN  
INN   USAN  
Official Name English
oxagrelate [INN]
Common Name English
6-PHTHALAZINECARBOXYLIC ACID, 3,4-DIHYDRO-1-(HYDROXYMETHYL)-5,7-DIMETHYL-4-OXO-, ETHYL ESTER
Common Name English
SC-32840
Code English
Ethyl 3,4-dihydro-1-(hydroxymethyl)-5,7-dimethyl-4-oxo-6-phthalazinecarboxylate
Systematic Name English
NSC-305351
Code English
OXAGRELATE [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C744
Created by admin on Fri Dec 15 15:05:18 UTC 2023 , Edited by admin on Fri Dec 15 15:05:18 UTC 2023
Code System Code Type Description
EPA CompTox
DTXSID9023469
Created by admin on Fri Dec 15 15:05:18 UTC 2023 , Edited by admin on Fri Dec 15 15:05:18 UTC 2023
PRIMARY
SMS_ID
100000083560
Created by admin on Fri Dec 15 15:05:18 UTC 2023 , Edited by admin on Fri Dec 15 15:05:18 UTC 2023
PRIMARY
INN
5187
Created by admin on Fri Dec 15 15:05:18 UTC 2023 , Edited by admin on Fri Dec 15 15:05:18 UTC 2023
PRIMARY
EVMPD
SUB09488MIG
Created by admin on Fri Dec 15 15:05:18 UTC 2023 , Edited by admin on Fri Dec 15 15:05:18 UTC 2023
PRIMARY
DRUG CENTRAL
2156
Created by admin on Fri Dec 15 15:05:18 UTC 2023 , Edited by admin on Fri Dec 15 15:05:18 UTC 2023
PRIMARY
PUBCHEM
41946
Created by admin on Fri Dec 15 15:05:18 UTC 2023 , Edited by admin on Fri Dec 15 15:05:18 UTC 2023
PRIMARY
FDA UNII
V17MYO89WO
Created by admin on Fri Dec 15 15:05:18 UTC 2023 , Edited by admin on Fri Dec 15 15:05:18 UTC 2023
PRIMARY
NSC
305351
Created by admin on Fri Dec 15 15:05:18 UTC 2023 , Edited by admin on Fri Dec 15 15:05:18 UTC 2023
PRIMARY
ChEMBL
CHEMBL153427
Created by admin on Fri Dec 15 15:05:18 UTC 2023 , Edited by admin on Fri Dec 15 15:05:18 UTC 2023
PRIMARY
CAS
56611-65-5
Created by admin on Fri Dec 15 15:05:18 UTC 2023 , Edited by admin on Fri Dec 15 15:05:18 UTC 2023
PRIMARY
NCI_THESAURUS
C80614
Created by admin on Fri Dec 15 15:05:18 UTC 2023 , Edited by admin on Fri Dec 15 15:05:18 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY