BROFOXINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H10BrNO2
Molecular Weight	256.096
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)OC(=O)NC2=CC=C(Br)C=C12

InChI

InChIKey=JRXGULDSFFLUAO-UHFFFAOYSA-N

InChI=1S/C10H10BrNO2/c1-10(2)7-5-6(11)3-4-8(7)12-9(13)14-10/h3-5H,1-2H3,(H,12,13)

HIDE SMILES / InChI

Molecular Formula	C10H10BrNO2
Molecular Weight	256.096
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29311 | http://www.google.ch/patents/US8460867 | https://www.google.es/patents/US5955459

Brofoxine is an anxiolytic, useful in the treatment of psychosis.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Psychosis 16 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29311 http://www.google.ch/patents/US8460867 https://www.google.es/patents/US5955459	Primary		Basic research	Unknown Approved Use Unknown
Anxiety 267 Sources: http://documents.tips/documents/brofoxine-reduced-anxiety-without-sedation.html https://www.ncbi.nlm.nih.gov/pubmed/29311	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Effects of brofoxine, a new anxiolytic, on experimentally induced conflict in rats.	1978	29311

Patents

Sample Use Guides

In Vivo Use Guide

In a 2 I-day uncontrolled study on 17 ambulant patients with moderate intensity anxiety neurosis as measured by the Hamilton Anxiety Scale, symptoms, as judged by patients and their physicians, were considerably ameliorated with brofoxine (Adria Labs) in daily doses from 60 to 100 mg.

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 14:59:33 UTC 2023` Edited by `admin` on `Fri Dec 15 14:59:33 UTC 2023`
Record UNII	6P1O8U403T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BROFOXINE

Official Name

English

BROFOXINE [USAN]

Common Name

English

brofoxine [INN]

Common Name

English

F.I.-6820

Code

English

6-Bromo-1,4-dihydro-4,4-dimethyl-2H-3,1-benzoxazin-2-one

Systematic Name

English

F.I. 6820

Code

English

2H-3,1-BENZOXAZIN-2-ONE, 6-BROMO-1,4-DIHYDRO-4,4-DIMETHYL-

Systematic Name

English

FI-6820

Code

English

Code System Code Type Description

ChEMBL

CHEMBL2106168