U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 8071 - 8080 of 167129 results

Status:
Investigational
Source:
INN:nordinone [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Nordinone is a synthetic anti-androgen. It was studied with respect to hirsutism and menstruation disturbances.
Status:
Investigational
Source:
NCT00007449: Phase 2 Interventional Unknown status HIV Infections
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:eperezolid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Eperezolid is an antibiotic agent developed for the treatment of a wide range of bacterial infections. The drug exerts its action by binding to 50 S ribosome subunit causing the inhibition of protein synthesis in bacterias. Eperezolid was tested in preclinical in vivo models of different becterial diseases in which it was shown to be active.
Status:
Investigational
Source:
NCT00401947: Phase 2 Interventional Terminated HCV Infection
(2006)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:mobecarb [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Mobecarb is morpholineacetic acid derivative patented by Carlo Erba Societa per Azioni to prevent vascular rupture among persons afflicted with arterial hypertension. In preclinical models Mobecarb shows the capillary protective activity in partially omentectomized rats.
Status:
Investigational
Source:
INN:mitindomide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Mitindomide was studied as an antineoplastic agent that inhibited the activity of the topoisomerase II. The drug underwent preclinical development; however, this study was discontinued.
Status:
Investigational
Source:
INN:pimetacin
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Pimetacin is the thio-ester of indometacin. It is antithrombotic and anti-inflammatory agent. Pimetacin produced dose-related enhancement of the OpZ-induced chemiluminescence from resident peritoneal macrophages.
Status:
Investigational
Source:
INN:pinafide [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Pinafide is a rodenticide and anti-protozoal agent. Pinafide shows strong cytostatic activity against both HeLa and KB cells and is moderately toxic to both mice and rats. It has been proved active against experimental tumors and shown to be inhibitor of two DNA viruses. Pinafide blocks cell growth by inhibiting DNA and RNA synthesis. It has been shown to bind to double-helical DNA by intercalation. Pinafide inhibited the activity of M. tuberculosis NAD⁺-dependent DNA ligase A at concentrations of 50 uM. At the chemical screening was found that pinafide inhibited B-Myb transcriptional activity in luciferase assays. The cross placental-barrier studies showed that 3H-pinafide was present in the 14-day fetuses.
Status:
Investigational
Source:
INN:difloxacin
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Difloxacin is an aryl fluoroquinolone derivative. The primary bacterial target of fluoroquinolones is the enzyme deoxyribonucleic acid gyrase. Difloxacin is very potent against a broad spectrum of bacteria including aerobic ana anaerobic gram-positive and gram-negative oragnisms. DICURAL® (difloxacin hydrochloride) TABLETS are indicated for the management of diseases in dogs associated with bacteria susceptible to difloxacin.
Status:
Investigational
Source:
USAN:DIFLUCORTOLONE PIVALATE [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Diflucortolone pivalate is a glucocorticoid drug. It might be used as anti-inflammatory and anti-allergic agent.

Showing 8071 - 8080 of 167129 results