Details
Stereochemistry | ACHIRAL |
Molecular Formula | C21H19F2N3O3 |
Molecular Weight | 399.3907 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCN(CC1)C2=CC3=C(C=C2F)C(=O)C(=CN3C4=CC=C(F)C=C4)C(O)=O
InChI
InChIKey=NOCJXYPHIIZEHN-UHFFFAOYSA-N
InChI=1S/C21H19F2N3O3/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14/h2-5,10-12H,6-9H2,1H3,(H,28,29)
DescriptionCurator's Comment: Description was created based on several sources, including http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013811.pdf | https://www.ncbi.nlm.nih.gov/pubmed/2680058
Curator's Comment: Description was created based on several sources, including http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013811.pdf | https://www.ncbi.nlm.nih.gov/pubmed/2680058
Difloxacin is an aryl fluoroquinolone derivative. The primary bacterial target of fluoroquinolones is the enzyme deoxyribonucleic acid gyrase. Difloxacin is very potent against a broad spectrum of bacteria including aerobic ana anaerobic gram-positive and gram-negative oragnisms. DICURAL® (difloxacin hydrochloride) TABLETS are indicated for the management of diseases in dogs associated with bacteria susceptible to difloxacin.
Originator
Approval Year
PubMed
Title | Date | PubMed |
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Activity of ciprofloxacin and other fluorinated quinolones against mycobacteria. | 1987 Apr 27 |
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In vitro susceptibilities of Mycobacterium tuberculosis to 10 antimicrobial agents. | 1988 Sep |
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In vitro and in vivo activities of clarithromycin against Mycobacterium avium. | 1989 Sep |
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Comparison of in vitro antimicrobial susceptibilities of Mycobacterium avium-M. intracellulare strains from patients with acquired immunodeficiency syndrome (AIDS), patients without AIDS, and animal sources. | 1990 Jul |
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In-vitro activities of quinolones against mycobacteria. | 1993 Dec |
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Determination of fluoroquinolones in serum using an on-line clean-up column coupled to high-performance immunoaffinity-reversed-phase liquid chromatography. | 2001 Apr 15 |
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Activity and postantibiotic effect of marbofloxacin, enrofloxacin, difloxacin and ciprofloxacin against feline Bordetella bronchiseptica isolates. | 2001 Jul 3 |
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Using nonaqueous capillary electrophoresis to analyze several quinolones in pig kidney samples. | 2002 Feb |
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Multiresidue determination of eleven quinolones in milk by liquid chromatography with fluorescence detection. | 2005 Nov-Dec |
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Simultaneous determination of (fluoro)quinolone antibiotics in kidney, marine products, eggs, and muscle by enzyme-linked immunosorbent assay (ELISA). | 2006 Apr 19 |
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Determination of fluoroquinolones in chicken tissues by LC-coupled electrospray ionisation and atmospheric pressure chemical ionisation. | 2006 Jan |
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Sensitive luminescent determination of DNA using the terbium(III)-difloxacin complex. | 2007 Feb 19 |
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Microbiological detection of 10 quinolone antibiotic residues and its application to artificially contaminated poultry samples. | 2007 Mar |
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Dual biosensor immunoassay-directed identification of fluoroquinolones in chicken muscle by liquid chromatography electrospray time-of-flight mass spectrometry. | 2007 Mar 14 |
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Pharmacokinetics after intravenous, intramuscular and subcutaneous administration of difloxacin in sheep. | 2007 Oct |
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Simultaneous determination of 13 quinolones in eggs using column high-performance liquid chromatography/electrospray ionization-tandem mass spectrometry and depletion of pefloxacin methanesulfonate in eggs. | 2008 Nov-Dec |
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Are liquid chromatography/electrospray tandem quadrupole fragmentation ratios unequivocal confirmation criteria? | 2009 Apr |
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Metabolism and excretion kinetics of 14C-labeled and non-labeled difloxacin in pigs after oral administration, and antimicrobial activity of manure containing difloxacin and its metabolites. | 2009 Apr |
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Pharmacokinetics and intramuscular bioavailability of difloxacin in dromedary camels (Camelus dromedarius). | 2009 Feb |
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Serovar distribution and antimicrobial susceptibility of swine Salmonella isolates from clinically ill pigs in diagnostic submissions from Indiana in the United States. | 2009 Mar |
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Ultra performance liquid chromatography tandem mass spectrometry performance evaluation for analysis of antibiotics in natural waters. | 2009 Mar |
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Photolysis of difloxacin and sarafloxacin in aqueous systems. | 2009 Oct |
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Fluoroquinolone antibiotic determination in bovine, ovine and caprine milk using solid-phase extraction and high-performance liquid chromatography-fluorescence detection with ionic liquids as mobile phase additives. | 2009 Oct 23 |
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Quantification of danofloxacin and difloxacin in chicken tissues in the presence of sarafloxacin as interference. | 2009 Sep 9 |
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Single-step extraction followed by LC for determination of (fluoro)quinolone drug residues in muscle, eggs, and milk. | 2010 Apr |
Patents
Sample Use Guides
The dose range of difloxacin in dogs is 5 to 10 mg/kg (2.3 to 4.6 mg/lb) once a day for 2-3 days beyond cessation of clinical signs to a maximum of 30 days.
For chickens and turkeys, the proposed dosage corresponds to a daily dose 10 mg/kg per day of difloxacin for up to 5 days.
Route of Administration:
Oral
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C795
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EMA VETERINARY ASSESSMENT REPORTS |
DICURAL (WITHDRAWN)
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WHO-VATC |
QJ01MA94
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CFR |
21 CFR 520.645
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EMA VETERINARY ASSESSMENT REPORTS |
DICURAL (WITHDRAWN)DICURAL (WITHDRAWN)
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EMA VETERINARY ASSESSMENT REPORTS |
PULSAFLOX [WITHDRAWN]
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EMA VETERINARY ASSESSMENT REPORTS |
PULSAFLOX [WITHDRAWN]
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EMA VETERINARY ASSESSMENT REPORTS |
DICURAL (WITHDRAWN)
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EMA VETERINARY ASSESSMENT REPORTS |
DICURAL (WITHDRAWN)
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m4430
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100000170013
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DB11511
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5Z7OO9FNFD
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C047225
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56206
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DIFLOXACIN
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)