Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H19F2N3O3.ClH.3H2O |
| Molecular Weight | 489.897 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.O.Cl.CN1CCN(CC1)C2=CC3=C(C=C2F)C(=O)C(=CN3C4=CC=C(F)C=C4)C(O)=O
InChI
InChIKey=SQHQDGFUHKBUDY-UHFFFAOYSA-N
InChI=1S/C21H19F2N3O3.ClH.3H2O/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14;;;;/h2-5,10-12H,6-9H2,1H3,(H,28,29);1H;3*1H2
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C21H19F2N3O3 |
| Molecular Weight | 399.3907 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013811.pdf | https://www.ncbi.nlm.nih.gov/pubmed/2680058
Curator's Comment: Description was created based on several sources, including http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013811.pdf | https://www.ncbi.nlm.nih.gov/pubmed/2680058
Difloxacin is an aryl fluoroquinolone derivative. The primary bacterial target of fluoroquinolones is the enzyme deoxyribonucleic acid gyrase. Difloxacin is very potent against a broad spectrum of bacteria including aerobic ana anaerobic gram-positive and gram-negative oragnisms. DICURAL® (difloxacin hydrochloride) TABLETS are indicated for the management of diseases in dogs associated with bacteria susceptible to difloxacin.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Quantitation of fluoroquinolones in honey using tandem mass spectrometry (LC-MS/MS): nested validation with two mass spectrometers. | 2010-12-15 |
|
| Antibiotic Treatment of Dogs and Cats during Pregnancy. | 2010-12-14 |
|
| Room temperature ionic liquid-mediated molecularly imprinted polymer monolith for the selective recognition of quinolones in pork samples. | 2010-12 |
|
| Rapid determination of fluoroquinolone residues in honey by a microbiological screening method and liquid chromatography. | 2010-10-07 |
|
| Dispersive liquid-liquid microextraction combined with nonaqueous capillary electrophoresis for the determination of fluoroquinolone antibiotics in waters. | 2010-10 |
|
| Effects of fish CYP inducers on difloxacin N-demethylation in kidney cell of Chinese idle (Ctenopharyngodon idellus). | 2010-09 |
|
| Fully automated screening of veterinary drugs in milk by turbulent flow chromatography and tandem mass spectrometry. | 2010-08 |
|
| Pharmacokinetics and milk penetration of difloxacin after a long-acting formulation for subcutaneous administration to lactating goats. | 2010-07 |
|
| Simultaneous determination of quinolones in fish by liquid chromatography coupled with fluorescence detection: comparison of sub-2 microm particles and conventional C18 columns. | 2010-07 |
|
| Effects of fish cytochromes P450 inducers and inhibitors on difloxacin N-demethylation in kidney of Chinese idle (Ctenopharyngodon idellus). | 2010-05 |
|
| Selective sample pretreatment by molecularly imprinted polymer monolith for the analysis of fluoroquinolones from milk samples. | 2010-04-02 |
|
| Aquatic photochemistry of fluoroquinolone antibiotics: kinetics, pathways, and multivariate effects of main water constituents. | 2010-04-01 |
|
| Single-step extraction followed by LC for determination of (fluoro)quinolone drug residues in muscle, eggs, and milk. | 2010-04 |
|
| Behaviour of (14)C-sulfadiazine and (14)C-difloxacin during manure storage. | 2010-03-01 |
|
| Comparison of several extraction techniques for multiclass analysis of veterinary drugs in eggs using ultra-high pressure liquid chromatography-tandem mass spectrometry. | 2010-02-28 |
|
| Simultaneous determination of quinolones for veterinary use by high-performance liquid chromatography with electrochemical detection. | 2010-02-01 |
|
| Simultaneous determination of eleven quinolones in animal feed by liquid chromatography with fluorescence and ultraviolet absorbance detection. | 2009-11-13 |
|
| Fluoroquinolone antibiotic determination in bovine, ovine and caprine milk using solid-phase extraction and high-performance liquid chromatography-fluorescence detection with ionic liquids as mobile phase additives. | 2009-10-23 |
|
| Photolysis of difloxacin and sarafloxacin in aqueous systems. | 2009-10 |
|
| Microbial screening methods for detection of antibiotic residues in slaughter animals. | 2009-10 |
|
| In vitro residual anti-bacterial activity of difloxacin, sarafloxacin and their photoproducts after photolysis in water. | 2009-10 |
|
| Quantification of danofloxacin and difloxacin in chicken tissues in the presence of sarafloxacin as interference. | 2009-09-09 |
|
| Rapid method for the determination and confirmation of fluoroquinolone residues in catfish using liquid chromatography/fluorescence detection and liquid chromatography-tandem mass spectrometry. | 2009-09-01 |
|
| Application of ionic liquids in high performance reversed-phase chromatography. | 2009-06-04 |
|
| Fully automatic sample treatment by integration of microextraction by packed sorbents into commercial capillary electrophoresis-mass spectrometry equipment: application to the determination of fluoroquinolones in urine. | 2009-04-15 |
|
| Simultaneous determination of seven fluoroquinolones in royal jelly by ultrasonic-assisted extraction and liquid chromatography with fluorescence detection. | 2009-04 |
|
| Are liquid chromatography/electrospray tandem quadrupole fragmentation ratios unequivocal confirmation criteria? | 2009-04 |
|
| Metabolism and excretion kinetics of 14C-labeled and non-labeled difloxacin in pigs after oral administration, and antimicrobial activity of manure containing difloxacin and its metabolites. | 2009-04 |
|
| Rapid determination of 19 quinolone residues in spiked fish and pig muscle by high-performance liquid chromatography (HPLC) tandem mass spectrometry. | 2009-03 |
|
| [Multi-residue determination of 11 quinolones in chicken muscle by high performance liquid chromatography with fluorescence detection]. | 2009-03 |
|
| Serovar distribution and antimicrobial susceptibility of swine Salmonella isolates from clinically ill pigs in diagnostic submissions from Indiana in the United States. | 2009-03 |
|
| Ultra performance liquid chromatography tandem mass spectrometry performance evaluation for analysis of antibiotics in natural waters. | 2009-03 |
|
| Simultaneous determination of 13 quinolones in eggs using column high-performance liquid chromatography/electrospray ionization-tandem mass spectrometry and depletion of pefloxacin methanesulfonate in eggs. | 2009-02-11 |
|
| Pharmacokinetics and intramuscular bioavailability of difloxacin in dromedary camels (Camelus dromedarius). | 2009-02 |
|
| Developing and optimizing an immunoaffinity cleanup technique for determination of quinolones from chicken muscle. | 2009-01-28 |
|
| [Simultaneous determination of 19 quinolone residues in honey using high performance liquid chromatography-tandem mass spectrometry]. | 2009-01 |
|
| Trace analysis of quinolone and fluoroquinolone antibiotics from wastewaters by liquid chromatography-electrospray tandem mass spectrometry. | 2008-12-19 |
|
| Ionic liquids as mobile phase additives for the high-performance liquid chromatographic analysis of fluoroquinolone antibiotics in water samples. | 2008-12 |
|
| Simultaneous determination of quinolone antibacterials in bovine milk by liquid chromatography-mass spectrometry. | 2008-11 |
|
| In vitro susceptibilities to fluoroquinolones in current and archived Mycoplasma gallisepticum and Mycoplasma synoviae isolates from meat-type turkeys. | 2008-10-15 |
|
| In vitro antibiotic susceptibility of Dutch Mycoplasma synoviae field isolates originating from joint lesions and the respiratory tract of commercial poultry. | 2008-08 |
|
| [Multiresidue determination of quinolones in animal and fishery products by HPLC]. | 2008-06 |
|
| Spectrofluorometric determination of certain quinolone antibacterials using metal chelation. | 2003-07-27 |
|
| In-vitro activities of quinolones against mycobacteria. | 1993-12 |
|
| Comparative in-vitro activities of ten fluoroquinolones and fusidic acid against Mycobacterium spp. | 1990-09 |
|
| Comparison of in vitro antimicrobial susceptibilities of Mycobacterium avium-M. intracellulare strains from patients with acquired immunodeficiency syndrome (AIDS), patients without AIDS, and animal sources. | 1990-07 |
|
| In vitro and in vivo activities of clarithromycin against Mycobacterium avium. | 1989-09 |
|
| Comparative antimycobacterial activities of difloxacin, temafloxacin, enoxacin, pefloxacin, reference fluoroquinolones, and a new macrolide, clarithromycin. | 1989-04 |
|
| In vitro susceptibilities of Mycobacterium tuberculosis to 10 antimicrobial agents. | 1988-09 |
|
| Activity of ciprofloxacin and other fluorinated quinolones against mycobacteria. | 1987-04-27 |
Patents
Sample Use Guides
The dose range of difloxacin in dogs is 5 to 10 mg/kg (2.3 to 4.6 mg/lb) once a day for 2-3 days beyond cessation of clinical signs to a maximum of 30 days.
For chickens and turkeys, the proposed dosage corresponds to a daily dose 10 mg/kg per day of difloxacin for up to 5 days.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 17:19:18 GMT 2025
by
admin
on
Wed Apr 02 17:19:18 GMT 2025
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| Record UNII |
CLS5XG8MST
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| Record Status |
Validated (UNII)
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| Record Version |
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CLS5XG8MST
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300000054154
Created by
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![Structure of 6-fluoro-7-(4-methylpiperazin-1-yl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid](/img/1fed3000-ed6f-4601-a5d4-613550056dc0.svg "Structure of 6-fluoro-7-(4-methylpiperazin-1-yl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid")
