PIMETACIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H21ClN2O3S
Molecular Weight	464.964
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C=C1)N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C2CC(=O)SCC4=CC=CN=C4

InChI

InChIKey=GVHKSMYWAFEEBI-UHFFFAOYSA-N

InChI=1S/C25H21ClN2O3S/c1-16-21(13-24(29)32-15-17-4-3-11-27-14-17)22-12-20(31-2)9-10-23(22)28(16)25(30)18-5-7-19(26)8-6-18/h3-12,14H,13,15H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C25H21ClN2O3S
Molecular Weight	464.964
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://apps.who.int/iris/bitstream/handle/10665/67830/WHO_EDM_QSM_2003.2.pdf | https://www.ncbi.nlm.nih.gov/pubmed/3859201 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 981, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Pimetacin is the thio-ester of indometacin. It is antithrombotic and anti-inflammatory agent. Pimetacin produced dose-related enhancement of the OpZ-induced chemiluminescence from resident peritoneal macrophages.

Approval Year

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

0.2-20 mg/kg/day for 2 days

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:36:17 GMT 2023` Edited by `admin` on `Fri Dec 15 15:36:17 GMT 2023`
Record UNII	Z6RX3C7B5V
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PIMETACIN

Official Name

English

1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-3-INDOLEACETIC ACID 3-PYRIDYLMETHYLTHIOESTER

Common Name

English

pimetacin [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257