U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 71 - 80 of 192 results

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

ATBC, Acetyl Tributyl Citrate is a plasticizer which can easily substitute those plasticizers to be phased out by the EU by February 2015. Actually, one of the main ATBC application is substitution of Phthalates plasticizers (Acetyl Tributyl Citrate is a Phthalate-FREE, bio based plasticizer). ATBC, is a safe, non-toxic plasticizer, biodegradable, mainly used as plasticizer of PVC, cellulose resin and synthetic rubber. Some of its main applications are toys for children, medical products such as blood bags, food packaging materials, and cosmetics; as well as all main PVC compounds, and fixative of inks in the flexographic industry. ATBC is almost colourless and odourless oily liquid, free of foreign materials, insoluble in water but soluble in alcohols and organic solvents. Compared with benzoates plasticizers, ATBC is perfectly odourless. Compared with other Phthalate-FREE plasticizers, ATBC is biodegradable, 100% biobased and it is not a kind of hydrogenated phthalate. Acetyl Tributyl Citrate is recognized as a Safe and Biodegradable plasticizer, with fewer biochemical effects.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Acetyltriethyl citrate (ATEC, Acetyl Triethyl Citrate) is a water-soluble plasticizer used in pharmaceutical plasticized polymers. It is an aliphatic ester of citric acid which is a clear oily liquid with essentially no odor. In pharmaceutical polymers, ATEC is used as a hydrophilic plasticizer in the coating of press-coated. tablets that are composed of hydroxypropyl methylcellulose acetate succinate or enteric polymer films consisting of polymethacrylic acid methylmethacrylate. ATEC is also used in protein films composed of whey protein or sunflower protein for buccal and sublingual films or particulate systems. Acetyl Triethyl Citrate and Acetyl Tributyl Citrate are used in nail products at concentrations up to 7%. In a guinea pig maximization test, Acetyl Triethyl Citrate was a sensitizer whereas Acetyl Tributyl Citrate was not. Limited clinical testing of Acetyl Triethyl Citrate and Acetyl Tributyl Citrate was negative for both skin irritation and sensitization. Physiologic effects noted with intravenous delivery of Acetyl Triethyl Citrate or Acetyl Tributyl Citrate include dose-related decreases in blood pressure and intestinal muscular spasms.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Triethyl citrate is a triester of ethyl alcohol and citric acid. It is a colorless, odorless liquid used as a food additive (E number E1505) to stabilize foams, especially as whipping aid for egg white. Triethyl citrate is a plasticizer, that plays an important role as a dispersing aid in the processing of polylactic acid/chitin nanocrystal (PLA/ChNC) nanocomposites.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)


Oxolamine under brand names Symphocal, Perebron is used in some countries as a cough suppressant for the treatment of pharyngitis, tracheitis, bronchitis, bronchiectasis, pertussis. Oxolamine possesses anti-inflammatory activity, which causes a reduction in the irritation of the nervous receptors of the respiratory tract.
Status:
Possibly Marketed Outside US
Source:
Japan:Nicametate Citrate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US
Source:
Japan:Mosapride Citrate
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Mosapride is a gastroprokinetic agent, a 5-HT4 receptor agonist and 5-HT3 receptor antagonist exhibiting no activity at dopamine D2, 5-HT1 and 5-HT2 receptors. Mosapride stimulates serotonin receptor in the digestive tract and increases acetylcholine release to promote upper digestive tract (stomach and duodenum) and lower digestive tract (colon) motility. It is usually used to treat heartburn, nausea and vomiting caused by chronic gastritis. Mosapride is approved and marketed in the countires of Asia and Latin America.
Status:
Possibly Marketed Outside US
Source:
Japan:Itopride Hydrochloride
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Itopride is a dopamine D2 receptor antagonist and inhibitor of acetylcholinesterase. It is indicated in the for the treatment of gastrointestinal symptoms caused by reduced gastrointestinal motility, such as functional non-ulcer dyspepsia (chronic gastritis), gastric fullness, rapid satiation, pain or discomfort in the upper abdomen, anorexia, heartburn, nausea, and vomiting. The drug is not approved in the USA or UK but is available in Japan and Western European countries.
Status:
Possibly Marketed Outside US
Source:
Canada:BETAINE HYDROCHLORIDE
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)