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Details

Stereochemistry ACHIRAL
Molecular Formula C14H19N3O.C6H8O7
Molecular Weight 437.4445
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXOLAMINE CITRATE

SMILES

CCN(CC)CCc1nc(-c2ccccc2)no1.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

InChI

InChIKey=RBZIGQJSMCOHSS-UHFFFAOYSA-N
InChI=1S/C14H19N3O.C6H8O7/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-9H,3-4,10-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

HIDE SMILES / InChI
Oxolamine under brand names Symphocal, Perebron is used in some countries as a cough suppressant for the treatment of pharyngitis, tracheitis, bronchitis, bronchiectasis, pertussis. Oxolamine possesses anti-inflammatory activity, which causes a reduction in the irritation of the nervous receptors of the respiratory tract.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Perebron

Approved Use

Unknown
Palliative
Perebron

Approved Use

Unknown
Palliative
Perebron

Approved Use

Unknown
Palliative
Perebron

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Effect of oxolamine on cough sensitivity in COPD patients.
2002 Jan
Effect of oxolamine on anticoagulant effect of warfarin.
2006 Jan 15
Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats.
2007 Apr
Patents

Sample Use Guides

In general, 15-25 mg per kilogram per day should be given by dividing four equal doses. In children over 2 years: 1-2 ml of 5 ml Adults: 2 ml of 5 ml 4 times daily 4 hours a day, after an equal amount of water.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
OXOLAMINE CITRATE
MART.   MI   WHO-DD  
Systematic Name English
NSC-759304
Code English
5-(2-(DIETHYLAMINO)ETHYL)-3-PHENYL-1,2,4-OXADIAZOLE CITRATE (1:1)
Systematic Name English
OXOLAMINE CITRATE [MART.]
Common Name English
FLOGOBRON
Brand Name English
BREDON
Brand Name English
BRONCATAR
Brand Name English
OXOLAMINE CITRATE [WHO-DD]
Common Name English
PRILON
Brand Name English
PEREBRON
Brand Name English
SKF-9976
Code English
AF-438
Code English
SKF 9976
Code English
OXOLAMINE CITRATE [MI]
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
217-760-6
Created by admin on Fri Jun 25 22:05:19 UTC 2021 , Edited by admin on Fri Jun 25 22:05:19 UTC 2021
PRIMARY
CAS
1949-20-8
Created by admin on Fri Jun 25 22:05:19 UTC 2021 , Edited by admin on Fri Jun 25 22:05:19 UTC 2021
PRIMARY
PUBCHEM
16045
Created by admin on Fri Jun 25 22:05:19 UTC 2021 , Edited by admin on Fri Jun 25 22:05:19 UTC 2021
PRIMARY
EVMPD
SUB03576MIG
Created by admin on Fri Jun 25 22:05:19 UTC 2021 , Edited by admin on Fri Jun 25 22:05:19 UTC 2021
PRIMARY
EPA CompTox
1949-20-8
Created by admin on Fri Jun 25 22:05:19 UTC 2021 , Edited by admin on Fri Jun 25 22:05:19 UTC 2021
PRIMARY
FDA UNII
K5X4XBR694
Created by admin on Fri Jun 25 22:05:19 UTC 2021 , Edited by admin on Fri Jun 25 22:05:19 UTC 2021
PRIMARY
MERCK INDEX
M8313
Created by admin on Fri Jun 25 22:05:19 UTC 2021 , Edited by admin on Fri Jun 25 22:05:19 UTC 2021
PRIMARY Merck Index
RXCUI
59053
Created by admin on Fri Jun 25 22:05:19 UTC 2021 , Edited by admin on Fri Jun 25 22:05:19 UTC 2021
PRIMARY RxNorm
MESH
C008735
Created by admin on Fri Jun 25 22:05:19 UTC 2021 , Edited by admin on Fri Jun 25 22:05:19 UTC 2021
PRIMARY