U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 61 - 70 of 192 results

Status:
US Previously Marketed
Source:
sodium succinate
(1921)
Source URL:
First marketed in 1921
Source:
sodium succinate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Succinic acid is a dicarboxylic acid, which has multiple biological roles as a metabolic intermediate being converted into fumarate by the enzyme succinate dehydrogenase in complex 2 of the electron transport chain which is involved in making ATP, and as a signaling molecule reflecting the cellular metabolic state. Succinate is generated in mitochondria via the tricarboxylic acid cycle (TCA), an energy-yielding process shared by all organisms. Succinate can exit the mitochondrial matrix and function in the cytoplasm as well as the extracellular space, changing gene expression patterns, modulating epigenetic landscape or demonstrating hormone-like signaling. Dysregulation of succinate synthesis, and therefore ATP synthesis, happens in some genetic mitochondrial diseases, such as Leigh's disease, and Mela's disease and degradation can lead to pathological conditions, such as malignant transformation, inflammation and tissue injury. Succinic acid is a precursor to some polyesters and a component of some alkyd resins. Succinic acid also serves as the bases of certain biodegradable polymers, which are of interest in tissue engineering applications. As a food additive and dietary supplement, succinic acid is generally recognized as safe by the U.S. Food and Drug Administration. Succinic acid is used primarily as an acidity regulator in the food and beverage industry. It is also available as a flavoring agent, contributing a somewhat sour and astringent component to umami taste.[11] As an excipient in pharmaceutical products, it is also used to control acidity or as a counter ion. Drugs involving succinate include metoprolol succinate, sumatriptan succinate, Doxylamine succinate or solifenacin succinate.
Disodium Cupric Citrate is citric acid salt with marked antioxidant activity. Disodium Cupric Citrate is one of the various forms in which the micronutrient copper is supplied in a fertiliser. Cupric supplementation at pharmacological doses beyond the recommendations of National Research Council has been widely applied in the feed industry to improve pig performance. Dietary Cupric Citrate supplementation enhanced growth performance in weaned pigs.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)


3-Phenyl-1-propanol is a fragrance ingredient used in many compounds. It may be found in fragrances used in decorative cosmetics, fine fragrances, shampoos, toilet soaps and other toiletries as well as in non-cosmetic products such as household cleaners and detergents. It is a colorless slightly oily liquid, possessing a warm and mild, balsamic-floral, sweet odor of moderate tenacity. This material has been reported to occur in nature, with highest quantities observed in Guava and Feyoa. The worldwide volume of use for 3-phenyl-1-propanol is in the region of 100–1000 metric tons per year. 3-Phenyl-1-propanol was used to study the hydrogenation of trans-cinnamaldehyde using water-soluble organometallic complexes. It was used as starting reagent during the enantioselective synthesis of (S)- and (R)-dapoxetine.
Status:
Possibly Marketed Outside US
Source:
Celladix C.E.F ADVANCED BRIGHTENING AMPOULE by 2359 US INC
(2023)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US
First approved in 2010
Source:
TL G-Fol OS by Trigen Laboratories, Inc.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Boron citrate is a part of triple complex Boron that supplier a high-dose of boron. Boron plays a critical role in everything from bone metabolism to brain function. It improves cognitive function, and decrease levels of inflammation in the body.
Status:
Possibly Marketed Outside US
Source:
part352
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Benzophenone is the organic compound. It is a flavouring agent evaluated as safe at current levels of intake by joint FAO/WHO Expert Committee on Food Additives (JECFA) and approved by FDA as a food additive and as UV protector. Substituted benzophenones such as oxybenzone (benzophenone-3) and dioxybenzone are used in sunscreens in cosmetics and as a sunscreen ingredients in some topical drugs in combination with skin lighteners for gradual fading of dark (brownish) areas in the skin such as freckles, age and liver spots or treatment of melanosis. Benzophenone derivatives can be used as a photo initiators. Benzophenone used in practical synthesis of some drugs.