U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 51 - 60 of 188 results

Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
US Previously Marketed
Source:
Tagathen by Lederle
(1948)
Source URL:
First approved in 1948
Source:
Tagathen by Lederle
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Chlorothen citrate (trade name Tagathen) is an antihistamine and a first generation H1 receptor antagonist, that have been used for the treatment of asthma, bronchitis, and bronchoconstriction.‘-5. Chlorothen is synthesized by condensation of 5-chloro-2-thienylchloride and N,N-dimethyl-N-(2-pyridinyl)ethylenediamine in the presence of sodium or potassium amide
Status:
US Previously Marketed
Source:
Chotbyn clihydrogen cit. by Flint
(1945)
Source URL:
First approved in 1945
Source:
Chotbyn clihydrogen cit. by Flint
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


TRICHOLINE CITRATE is indicated for the treatment and management of hepatic disorders and asthma symptoms in adults. It exerts lipotropic action in the hepatic cells. It also can lower the symptoms of asthma and reducing the pro-inflammatory and inflammatory mediators of the leukotriene pathway.
Status:
US Previously Marketed
First marketed in 1921
Source:
sodium succinate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Succinic acid is a dicarboxylic acid, which has multiple biological roles as a metabolic intermediate being converted into fumarate by the enzyme succinate dehydrogenase in complex 2 of the electron transport chain which is involved in making ATP, and as a signaling molecule reflecting the cellular metabolic state. Succinate is generated in mitochondria via the tricarboxylic acid cycle (TCA), an energy-yielding process shared by all organisms. Succinate can exit the mitochondrial matrix and function in the cytoplasm as well as the extracellular space, changing gene expression patterns, modulating epigenetic landscape or demonstrating hormone-like signaling. Dysregulation of succinate synthesis, and therefore ATP synthesis, happens in some genetic mitochondrial diseases, such as Leigh's disease, and Mela's disease and degradation can lead to pathological conditions, such as malignant transformation, inflammation and tissue injury. Succinic acid is a precursor to some polyesters and a component of some alkyd resins. Succinic acid also serves as the bases of certain biodegradable polymers, which are of interest in tissue engineering applications. As a food additive and dietary supplement, succinic acid is generally recognized as safe by the U.S. Food and Drug Administration. Succinic acid is used primarily as an acidity regulator in the food and beverage industry. It is also available as a flavoring agent, contributing a somewhat sour and astringent component to umami taste.[11] As an excipient in pharmaceutical products, it is also used to control acidity or as a counter ion. Drugs involving succinate include metoprolol succinate, sumatriptan succinate, Doxylamine succinate or solifenacin succinate.
Disodium Cupric Citrate is citric acid salt with marked antioxidant activity. Disodium Cupric Citrate is one of the various forms in which the micronutrient copper is supplied in a fertiliser. Cupric supplementation at pharmacological doses beyond the recommendations of National Research Council has been widely applied in the feed industry to improve pig performance. Dietary Cupric Citrate supplementation enhanced growth performance in weaned pigs.