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Restrict the search for
tyrosine
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Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
AG-126 is the putative protein tyrosine kinase (PTK) inhibitor. It was found to rescue mice from lethal consequences of bacterial lipopolysaccharide (LPS) administration in a model of septic shock. AG126 treatment has beneficial effects in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. AG126 alleviates the clinical symptoms, diminishes encephalitogenic Th17 differentiation, reduces inflammatory CNS infiltration as well as microglia activation and attenuates myelin damage. AG-126 have recently been shown to protect from acute kidney injury in experimental animal models of ischemia-reperfusion and sepsis-induced injury. AG-126 modulates secondary damage in experimental spinal cord trauma.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
AG1478 (also known as Tyrphostin AG 1478 ) is a selective EGFR inhibitor, which induced cell cycle arrest in G1 phase, is developed as potential drug for nasopharyngeal carcinoma treatment. In addition was shown, that AG1478 effectively blocked the leiomyoma cell growth and is unaffected by the presence of physiological concentrations of progesterone and estradiol. The growth-arresting properties of AG1478, unaffected by ovarian steroidal hormones, identify it as a potential lead agent for the non-surgical management of uterine leiomyomas. Also was investigated the action of the combination AG1478 in combination with HGF tyrosine kinase inhibitors on non-small cell lung cancer (NSCLC) cells, and was suggested, that these combinations of drugs could be potentially used for treatment of NSCLC.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Kaempferide (3,5,7-trihydroxy-4′-methoxyflavone,
Kae) is a naturally occurring flavonoid that is
isolated from the roots of Alpinia officinarum (lesser galangal). Like other flavonoids, Kae also has a very good
antioxidant properties and Kae can effectively reduce 1,1-
diphenyl-2-picrylhydrazyl (DPPH). Studies have shown
that Kae has anticancer and antihypertension effects. Kaempferide protects against myocardial Ischemia/reperfusion Injury through activation of the PI3K/Akt/GSK-3β pathway. Kaempferide inhibited potent antioxidant activity. Kaempferide is one of the candidates for active compound in propolis. Kaempferide, the most active among the four flavonoids isolated and characterized from Chromolaena odorata, induces apoptosis in cervical cancer cells while being pharmacologically safe.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
ST-638 (alpha-cyano-3-ethoxy-4-hydroxy-5-phenyl-methylcinnamamide) is a protein tyrosine kinase inhibitor that also inhibits HGF-induced MAP kinase activation in hepatocytes. ST638 has also shown to inhibit PC-PLD (phospholipase D) activity in human neutrophils and suppresses tyrosine phosphorylation induced by tumor necrosis factor-α and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.
