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Restrict the search for
tyrosine
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
PRT062607 (BIIB-057; P 50515 PRT-2607; PRT062607) is a highly specific and potent inhibitor of spleen tyrosine kinase (Syk). PRT062607 (BIIB-057) has a desirable pharmacokinetics profile and is capable of safely, potently, and selectively suppressing SYK kinase function in humans following once-daily oral dosing. The compound is being evaluated for the treatment of chronic inflammatory diseases; including rheumatoid arthritis, systemic lupus erythematosus, non-Hodgkin's lymphoma and chronic lymphocytic leukaemia. Phase I development is underway in the US and the UK for the treatment of patients with inflammation and cancer. Phase I development is also being conducted in rheumatoid arthritis and systemic lupus erythematosus, presumably in the US.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Sodium thiophosphate (or sodium monothiophosphate) a biochemical reagent, a specific inhibitor of protein tyrosine phosphatase and a competitive inhibitor of alkaline phosphatase. Thiophosphate was effective in inducing apoptosis in some leukemia cell lines including CEM and K562 and a lymphoma cell line, Raji. In addition, monothiophosphate entered intracellular nucleotide pools and served as an effective precursor for the phosphorylation of nuclear proteins in vivo.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase; it does not inhibit protein kinase A or C. It was shown, that lavendustin A inhibited histamine release from human mast cell line.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) that exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities. Panaxatriol increases expression of heme oxygenase 1 (HO-1) and activation of Nrf2 signaling in neurons in a PI3K/Akt-dependent manner. Panaxatriol also decreases acetaminophen-induced increases in ALT and TNF-α, preventing liver injury in vivo. Additionally, panaxatriol inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential. Panaxatriol is a tyrosine hydroxylase inducer. It shows neuroprotective and cardioprotective effects in vivo. Panaxatriol enhances antioxidant activity and inhibits mitochondria-mediated apoptosis. Pretreatment with ginseng total saponin, especially panaxatriol, ameliorates I/R-induced myocardial damage and this protection is caused by reducing oxidative stress. Panaxatriol can relieve myelosuppression induced by radiation injury. The abilities of regulating the expression of hemopoietic growth factor GM-CSF and promoting the maturation of bone marrow cells may be responsible for some of these beneficial effects.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Firefly luciferin (D-luciferin) is the luciferin, or light-emitting compound, found in many firefly (Lampyridae) species. D-luciferin is the substrate for firefly luciferase (Photinus pyralis). Luciferase catalyzes the oxidation of Firefly luciferin to oxyluciferin in the presence of ATP and magnesium, resulting in bioluminescence. This bioluminescent reaction is the most efficient known in nature, with about 90% of the energy released being converted to light. The luciferin/luciferase system is used as a very sensitive reporter assay for gene expression. It can also be used for ATP assays in research applications or to detect bacterial contamination. A luciferase-based ATP-TCA (ATP-tumour chemosensitivity test) to measure ATP levels was designed in the 1990s. This method permits the effects of different medicines and their combinations to be assessed in tumour biopsy specimens and has been used for chemotherapy drug selection for the treatment of ovarian cancer, cervical cancer, and breast cancer as well as melanoma and hepatoma.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
C-1311 is an imidazoacridinone analog. It is a next-generation investigational anticancer drug. It is an antitumor inhibitor of topoisomerase II and FMS-like tyrosine kinase 3 receptor. It was evaluated in phase I and II clinical trials for the treatment of various types of tumors. Mild treatment-related adverse events were thrombocytopenia, anemia, nausea, vomiting and diarrhea. Serious adverse event is neutropenia.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Orsellinic acid is a common salicylic acid unit in the biosynthesis of secondary metabolites in actinomycetes, fungi, and lichens, formally isolated from Chaetomium cochliodes in 1959. Orsellinic acid is a key biosynthetic intermediate of many depside metabolites in lichen and fungi. Orsellinic acid is also an important polar co-metabolite present in many fungi, notably Trichomonacea, however, its contribution to overall bioactivity is not well understood. Orsellinic acid is a useful standard for bioassay and analytical techniques for dereplication of common cometabolites.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
