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Restrict the search for
tyrosine
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Terreic acid is a metabolite with antibiotic properties produced by the fungus Aspergillus terreus. It was found, that terreic acid inactivated UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA), a bacterial cell wall biosynthetic enzyme, by covalently attaching to Cys115. This compound also inhibits the catalytic activity of BTK (Bruton's tyrosine kinase) and the interaction of Btk with protein kinase C beta type (PKCβII) without affecting the activity of PKC.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Viridicatol is a polar metabolite first isolated from Penicillium cyclopium and P. viridicatum by Birkinshaw and collaborators in
1963. Viridicatol is a 2,3-dihydroxyquinoline which, like its analogue viridicatin, exists in equilibrium with its keto-tautomer.
Viridicatol acts as an anti-inflammatory agent by suppressing the expression of pro-inflammatory mediators such as inducible
nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2, via inhibition of the nuclear factor-kappa B (NF-κB) pathway in
LPS stimulated cells. Further, viridicatol is a selective inhibitor of PTP1B, a potential drug target for the treatment of type 2
diabetes and obesity. Viridicatol revealed potent antibacterial activity against Staphylococcus aureus.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Echinulin is an alkaloid isolated from the fungal extract, which inhibits the protein-tyrosine phosphatase 1B (PTP1B) and can be further investigated for the treatment of diabetes.
