in mice: Twenty eight albino mice were fasted for 12 h prior to induction of hyperglycemia. Diabetes was induced using freshly prepared solution of alloxan monohydrate (i.p. at 120 mg/kg body weight). After the induction, the diabetic animals were randomly divided into seven groups (n = 4) and treated orally according to the following protocols: Group B: alloxan +20 mg/kg of 1/2 Compounds echinulin (1) and arestrictin B (2), (or 1/2), two isomeric indole-containing diketopiperazine alkaloids, were obtained as a mixture (56:54). They were thus evaluated as one sample.

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