Emodic acid

OC(=O)C1=CC(O)=C2C(=O)C3=C(C=C(O)C=C3O)C(=O)C2=C1

InChIKey=ZJXVNNSMRGTDBI-UHFFFAOYSA-N

InChI=1S/C15H8O7/c16-6-3-8-12(10(18)4-6)14(20)11-7(13(8)19)1-5(15(21)22)2-9(11)17/h1-4,16-18H,(H,21,22)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Tyrosine-protein kinase JAK2 59 Target ID: O60674 Gene ID: 3717.0 Gene Symbol: JAK2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/25038528	Inhibitor 8504		15.0 µM [IC50]

PubMed

Title	Date	PubMed
In silico identification of natural product inhibitors of JAK2.	2015-01	25038528

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:56:05 GMT 2025` Edited by `admin` on `Mon Mar 31 19:56:05 GMT 2025`
Record UNII	EXD4256WVW
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

Emodic acid

Common Name

English

2-Anthracenecarboxylic acid, 9,10-dihydro-4,5,7-trihydroxy-9,10-dioxo-

Preferred Name

English

9,10-Dihydro-4,5,7-trihydroxy-9,10-dioxo-2-anthracenecarboxylic acid

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID80963942

Created by admin on Mon Mar 31 19:56:05 GMT 2025 , Edited by admin on Mon Mar 31 19:56:05 GMT 2025

PRIMARY

CAS

478-45-5

Created by admin on Mon Mar 31 19:56:05 GMT 2025 , Edited by admin on Mon Mar 31 19:56:05 GMT 2025

PRIMARY

PUBCHEM

361510

Created by admin on Mon Mar 31 19:56:05 GMT 2025 , Edited by admin on Mon Mar 31 19:56:05 GMT 2025

PRIMARY

FDA UNII

EXD4256WVW

Created by admin on Mon Mar 31 19:56:05 GMT 2025 , Edited by admin on Mon Mar 31 19:56:05 GMT 2025

PRIMARY