Pirquinozol, a pyrazolo[1,5-c]quinazoline, is an orally effective anti-allergic agent as demonstrated in animal model systems. Pirquinozol is prodrug, requiring oxidation to SQ 12,903 for expression of maximum antiallergic activity. In-vitro, pirquinozol inhibits histamine release from rat mast cells in a manner similar to that observed for disodium cromoglycate (DSCG) and doxantrazole. In the rat, pirquinozol is not an antagonist of histamine in serotonin, in beta adrenergic agonist or a bronchodilator. Prophylactically administered pirquinozol inhibits immunologically-induced bronchospasm in rats passively sensitized with whole rat serum containing IgE anti-egg albumin, as measured by changes in both airway conductance and dynamic compliance.

Disofenin is an iminodiacetic acid derivative with no known pharmacologic actions at the doses recommended. Technetium Tc 99m disofenin injection is a radiopharmaceutical. Technetium Tc99m disofenin is indicated as a hepatobiliary imaging agent. Technetium Tc99m disofenin is indicated in the diagnosis of acute cholecystitis as well as to rule out the occurrence of acute cholecystitis in suspected patients with right upper quadrant pain, fever, jaundice, right upper quadrant tenderness and mass or rebound tenderness, but not limited to these signs and symptoms. Itching at the site of injection progressing to erythema multiforme has been reported following single administration. Also, rare cases of chills and nausea have been reported.

(R)-(+)-Propranolol (also known as DEXPROPRANOLOL) is the less active enantiomer of propranolol and is an antagonist of the beta-adrenergic receptor. It is known, that propranolol had been used for myocardial infarction; arrhythmia, anxiety and some other disease, but adverse effects instigated the replacement by newer drugs.

Hexedine has been used as an antimicrobial agent and drug constituent. Information about the current use of this drug is not available.

Flazalone is a nonsteroidal anti-inflammatory drug. In acute irritant anti-inflammatory tests, flazalone exhibited a wide spectrum of activity. The compound was active in affecting the course of paw swelling in adjuvant arthritis when given daily either at the outset of the polyarthritis or after induction. The most unusual aspect of this compound is its ability to inhibit graft rejection in goldfish and rabbits.

Intrazole (also known as BL-R743) is an indole derivative patented by Bristol-Myers Co and studied for Fungal infections treatment. In preclinical modes Intrazole shows anti-inflammatory activity in intact and adrenalectomized animals, employing the foot edema assay. Intrazole increased the antiinflammatory effect of hydrocortisone in the granuloma pouch model and effectively inhibited or alleviated adjuvant-induced polyarthritis.

Chloralose (alpha-Chloralose, 1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose) is an avicide, and a rodenticide commonly used for the control of mice and birds. Since its initial description in 1893, alpha-chloralose has undergone extensive pharmacologic evaluation. It has been characterized as a compound possessing potent CNS activity and has been evaluated in humans and animal models for its therapeutic properties. Though the toxicity of the compound prohibits its use as a human therapeutic agent, it has been employed widely as an animal anesthetic in the laboratory setting. α-Chloralose is widely used as an anesthetic in studies of the cerebrovasculature because of its presumed minimal depression of autonomic function. α-Chloralose acts as the positive allosteric modulator of GABA-A receptor and increases the affinity for GABA 5-fold and produced a small increase in the efficacy of GABA. Studies of α-Chloralose interactions with other allosteric modulators determined that α-Chloralose binds to a site on the GABAA receptor complex distinct from the benzodiazepine, neurosteroid and barbiturate sites.