FLAZALONE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C19H19F2NO2
Molecular Weight	331.3565
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCC(O)(C(C1)C(=O)C2=CC=C(F)C=C2)C3=CC=C(F)C=C3

InChI

InChIKey=PPQZABOURJVKNI-UHFFFAOYSA-N

InChI=1S/C19H19F2NO2/c1-22-11-10-19(24,14-4-8-16(21)9-5-14)17(12-22)18(23)13-2-6-15(20)7-3-13/h2-9,17,24H,10-12H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7668

Flazalone is a nonsteroidal anti-inflammatory drug. In acute irritant anti-inflammatory tests, flazalone exhibited a wide spectrum of activity. The compound was active in affecting the course of paw swelling in adjuvant arthritis when given daily either at the outset of the polyarthritis or after induction. The most unusual aspect of this compound is its ability to inhibit graft rejection in goldfish and rabbits.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine transporter 180 Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10669562	Inhibitor 8297		5.7 µM [Ki]
prostaglandin biosynthetic process 23 Target ID: GO:0001516 Sources: https://www.ncbi.nlm.nih.gov/pubmed/816374	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatoid arthritis 316 Sources: Scherrer, R. (2012) Anti-inflammatory Agents Part I: Chemistry and Pharmacology, v.1, page 198, retrieved from: https://books.google.ru/books?id=-DZRx_kaaCMC	Primary		Phase I 428	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
Alfa Chemistry	21221-18-1	https://www.alfa-chemistry.com/cas_21221-18-1.htm
Aurora Fine Chemicals LLC	A12.864.515	http://online.aurorafinechemicals.com/info?ID=A12.864.515
ChemMol	99048690	http://www.chemmol.com/chemmol/99048690.html
Chemspace	CSSS00015225351	https://chem-space.com/CSSS00015225351
Debye Scientific	DS-011364	http://www.debyesci.com/cas_21221-18-1.html
MolPort	MolPort-000-906-374	https://www.molport.com/shop/molecule-link/MolPort-000-906-374
Smolecule	S562070	https://www.smolecule.com/products/s562070
THE BioTek	bt-368938	https://www.thebiotek.com/product/others/bt-368938
Vitas-M Laboratory	STK097171	http://www.request.vitasmlab.biz/index.php?option=com_search_stk&Itemid=22&stk=STK097171&?utm_source=pubchem&utm_medium=p_search_link&utm_campaign=pubchem_search&utm_content=pubchem_slink
mcule	MCULE-1635753904	https://mcule.com/MCULE-1635753904/

PubMed

Title	Date	PubMed
The pharmacology of flazalone: a new class of anti-inflammatory agent.	1976 Aug	7668
Effect of substrate concentration on inhibition of prostaglandin synthetase of bull seminal vesicles by anti-inflammatory drugs and fenamic acid analogs.	1976 Mar 26	816374
Nonsteroid anti-inflammatory agents: regulators of the phagocytic secretion of lysosomal enzymes from guinea-pig neutrophils.	1978 Nov	712644

Patents

Sample Use Guides

In Vivo Use Guide

Flazalone inhibits edema induced by avariety of agents, such as carrageenan, serotonin, egg white, dextran, and yeast, at 50—100 mg/kg.

Route of Administration: Unknown

In Vitro Use Guide

Flazalone inhibits the RNA and DNA synthesis of lymphocytes in vitro at 0.5 mM.

Name

Type

Language

FLAZALONE

Official Name

English

(4-FLUOROPHENYL)(4-(4-FLUOROPHENYL)-4-HYDROXY-1-METHYL-3-PIPERIDINYL)METHANONE

Systematic Name

English

P-FLUOROPHENYL 4-(P-FLUOROPHENYL)-4-HYDROXY-1-METHYL-3-PIPERIDYL KETONE

Common Name

English

R-760

Code

English

flazalone [INN]

Common Name

English

METHANONE, (4-FLUOROPHENYL)(4-(4-FLUOROPHENYL)-4-HYDROXY-1-METHYL-3-PIPERIDINYL)-

Systematic Name

English

NSC-102629

Code

English

FLAZALONE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257