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Details

Stereochemistry UNKNOWN
Molecular Formula C19H19F2NO2
Molecular Weight 331.3565
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLAZALONE

SMILES

CN1CCC(O)(C(C1)C(=O)C2=CC=C(F)C=C2)C3=CC=C(F)C=C3

InChI

InChIKey=PPQZABOURJVKNI-UHFFFAOYSA-N
InChI=1S/C19H19F2NO2/c1-22-11-10-19(24,14-4-8-16(21)9-5-14)17(12-22)18(23)13-2-6-15(20)7-3-13/h2-9,17,24H,10-12H2,1H3

HIDE SMILES / InChI

Description

Flazalone is a nonsteroidal anti-inflammatory drug. In acute irritant anti-inflammatory tests, flazalone exhibited a wide spectrum of activity. The compound was active in affecting the course of paw swelling in adjuvant arthritis when given daily either at the outset of the polyarthritis or after induction. The most unusual aspect of this compound is its ability to inhibit graft rejection in goldfish and rabbits.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
5.7 µM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Flazalone inhibits edema induced by avariety of agents, such as carrageenan, serotonin, egg white, dextran, and yeast, at 50—100 mg/kg.
Route of Administration: Unknown
In Vitro Use Guide
Flazalone inhibits the RNA and DNA synthesis of lymphocytes in vitro at 0.5 mM.