DISOFENIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H26N2O5
Molecular Weight	350.4094
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C1=CC=CC(C(C)C)=C1NC(=O)CN(CC(O)=O)CC(O)=O

InChI

InChIKey=UDUSOMRJOPCWHT-UHFFFAOYSA-N

InChI=1S/C18H26N2O5/c1-11(2)13-6-5-7-14(12(3)4)18(13)19-15(21)8-20(9-16(22)23)10-17(24)25/h5-7,11-12H,8-10H2,1-4H3,(H,19,21)(H,22,23)(H,24,25)

HIDE SMILES / InChI

Molecular Formula	C18H26N2O5
Molecular Weight	350.4094
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/pro/technetium-tc-99m-disofenin.html | https://www.mayoclinic.org/drugs-supplements/technetium-tc-99m-disofenin-intravenous-route/description/drg-20122631 | https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=32c493f8-c4fa-4564-911b-ca2e1146c754 | https://pharmacyce.unm.edu/nuclear_program/neolibrary/libraryfiles/package_inserts/hepatolite_PI.pdf | https://www.ncbi.nlm.nih.gov/books/NBK501567/

Disofenin is an iminodiacetic acid derivative with no known pharmacologic actions at the doses recommended. Technetium Tc 99m disofenin injection is a radiopharmaceutical. Technetium Tc99m disofenin is indicated as a hepatobiliary imaging agent. Technetium Tc99m disofenin is indicated in the diagnosis of acute cholecystitis as well as to rule out the occurrence of acute cholecystitis in suspected patients with right upper quadrant pain, fever, jaundice, right upper quadrant tenderness and mass or rebound tenderness, but not limited to these signs and symptoms. Itching at the site of injection progressing to erythema multiforme has been reported following single administration. Also, rare cases of chills and nausea have been reported.

Approval Year

PubMed

Title	Date	PubMed
Nuclear imaging of the liver: is there a diagnostic role of HIDA in posttransplantation?	2008-07-11	19249514
Biliary atresia: feasibility of mangafodipir trisodium-enhanced MR cholangiography for evaluation.	2005-04	15749972
Corn oil emulsion: a simple cholecystagogue for diagnosis of chronic acalculous cholecystitis.	2005-01	15632036
Alternative quality control for technetium-99m IDA complexes.	2004-12	15388103
Meal size and starch content affect gastric emptying in horses.	2004-07	15253086

Sample Use Guides

In Vivo Use Guide

The suggested dose range to be employed in the average patient (70kg) is: Non-Jaundiced patient: 37 - 185 MBq (1-5 mCi) Patient with serum bilirubin level greater than 5 mg/dL: 111 - 296 MBq (3-8 mCi)

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:53:53 GMT 2025` Edited by `admin` on `Mon Mar 31 17:53:53 GMT 2025`
Record UNII	4V891LH5NB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DISOFENIN [II]

Preferred Name

English

DISOFENIN

Official Name

English

disofenin [INN]

Common Name

English

DISOFENIN [USAN]

Common Name

English

DISOFENIN [MI]

Common Name

English

GLYCINE, N-(2-((2,6-BIS(1-METHYLETHYL)PHENYL)AMINO)-2-OXOETHYL)-N-(CARBOXYMETHYL)-

Systematic Name

English

[[[(2,6-Diisopropylphenyl)carbamoyl]methyl]imino]diacetic acid

Systematic Name

English

DISOFENIN [VANDF]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1937