Nicoclonate is a nicotinic acid derivative. It is an antilipidemic drug.

Silydianin is a flavonolignan from Silymarin, which is the major constituent of milk thistle extract. Silydianin, an active constituent of Silybium marianum, have inhibitory properties against the P2Y12 receptor and block ADP-induced blood platelet activation. Silydianin has antiinflammatory activity, it regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger. Silydianin non-competitively inhibits the lipoxygenase from soybeans in vitro. It also inhibits the formation of prostaglandins in vitro.

Nicanartine [MRZ 3124] is an antioxidant and cholesterol-lowering agent that was under development with Merz + Co. (later Merz Pharma) in Germany. Development of nicanartine for the treatment of atherosclerosis and reperfusion injury was discontinued at the phase I stage.

Flupimazine was invented as a neuroleptic agent. However, information about the current use of this drug is not available.

Draquinolol is a cardioselective beta-adrenoceptor antagonist with a long duration of action in vivo. The long duration of action of draquinolol in vivo is due to the formation of a tight complex with beta 1-adrenoceptors. Draquinolol reduced an exercise tachycardia.

Doxpicomine is the hydrochloride salt of l-3[(dimethylamino)-(m-dioxan-5-yl)methyl]pyridine, a derivative of substituted 1,3 dioxanes. Its analgesic effect appears to be mediated centrally through opiate-like receptors. Preclinical animal studies revealed analgesic activity and duration of action of the same order as that of meperidine and codeine when administered subcutaneously and of codeine but of shorter duration when administered orally. The analgesic effects were reversed by naloxone. The drug did not reduce or antagonize the analgesic effect of morphine. Drowsiness is an expected response to effective analgesics. It was the foremost side effect observed but was of short duration and minimal intensity and did not interfere with the postoperative regimen of coughing, deep breathing, and early ambulation. Nausea and vomiting were not reported after doxpicomine.

Siltenzepine is a tricyclic compound. It is an anti-acid agent. It is used in the treatment of peptic ulcers.

Orestrate was developed as an estrogenic steroid that has never been marketed.

Osmadizone was investigated as a uricosuric agent. Information about the current use of this compound is not available.