DRAQUINOLOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C24H30N2O4
Molecular Weight	410.506
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C=C1)C=C(N(C)C2=O)C3=CC=C(OCC(O)CNC(C)(C)C)C=C3

InChI

InChIKey=MZELTXWHFDTAOO-UHFFFAOYSA-N

InChI=1S/C24H30N2O4/c1-24(2,3)25-14-18(27)15-30-19-9-6-16(7-10-19)22-12-17-8-11-20(29-5)13-21(17)23(28)26(22)4/h6-13,18,25,27H,14-15H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C24H30N2O4
Molecular Weight	410.506
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2883988 | https://www.ncbi.nlm.nih.gov/pubmed/2859028 | Morton, I.K., Hall, J.M. (2012) Concise Dictionary of Pharmacological Agents, page 106, retrieved from: https://books.google.ru/books?id=tsjrCAAAQBAJ

Draquinolol is a cardioselective beta-adrenoceptor antagonist with a long duration of action in vivo. The long duration of action of draquinolol in vivo is due to the formation of a tight complex with beta 1-adrenoceptors. Draquinolol reduced an exercise tachycardia.

Approval Year

PubMed

Title	Date	PubMed
Radioligand binding studies with 3-(4-(2-hydroxy-3-((1, 1-dimethylethyl)-amino)-propoxy)-phenyl)-7-methoxy-2-methyl- 1(2H)-isoquinolinone (HI-42), a new cardioselective beta-adrenoceptor blocker with long-lasting effects in vivo.	1985	2859028
The assessment in man of the beta-adrenoceptor blocking activity and cardioselectivity of H-I 42 BS, a long acting beta-adrenoceptor blocking drug.	1987 Apr	2883988
Beta-adrenoceptor-binding studies of the cardioselective beta blockers bisoprolol, H-I 42 BS, and HX-CH 44 BS to heart membranes and intact ventricular myocytes of adult rats: two beta 1-binding sites for bisoprolol.	1990 Mar	1691366

Sample Use Guides

In Vivo Use Guide

Single dose - 400 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:27:27 UTC 2023` Edited by `admin` on `Fri Dec 15 16:27:27 UTC 2023`
Record UNII	K3B3L3Q0GV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DRAQUINOLOL

Official Name

English

3-(P-(3-(TERT-BUTYLAMINO)-2-HYDROXYPROPOXY)PHENYL)-7-METHOXY-2-METHYLISOCARBOSTYRIL

Common Name

English

HI-42

Code

English

DRAQUINOLOL [MART.]

Common Name

English

1(2H)-ISOQUINOLINONE, 3-(4-(3-((1,1-DIMETHYLETHYL)AMINO)-2-HYDROXYPROPOXY)PHENYL)-7-METHOXY-2-METHYL-

Systematic Name

English

H-I-42BS

Code

English

draquinolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576