DRAQUINOLOL

Investigational

Details

Stereochemistry	RACEMIC
Molecular Formula	C24H30N2O4
Molecular Weight	410.506
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

COC1=CC2=C(C=C1)C=C(N(C)C2=O)C3=CC=C(OCC(O)CNC(C)(C)C)C=C3

InChI

InChIKey=MZELTXWHFDTAOO-UHFFFAOYSA-N

InChI=1S/C24H30N2O4/c1-24(2,3)25-14-18(27)15-30-19-9-6-16(7-10-19)22-12-17-8-11-20(29-5)13-21(17)23(28)26(22)4/h6-13,18,25,27H,14-15H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C24H30N2O4
Molecular Weight	410.506
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description

Draquinolol is a cardioselective beta-adrenoceptor antagonist with a long duration of action in vivo. The long duration of action of draquinolol in vivo is due to the formation of a tight complex with beta 1-adrenoceptors. Draquinolol reduced an exercise tachycardia.

Approval Year

PubMed

PubMed

Show entries

Title	Date	PubMed
The assessment in man of the beta-adrenoceptor blocking activity and cardioselectivity of H-I 42 BS, a long acting beta-adrenoceptor blocking drug.	1987 Apr	2883988
Beta-adrenoceptor-binding studies of the cardioselective beta blockers bisoprolol, H-I 42 BS, and HX-CH 44 BS to heart membranes and intact ventricular myocytes of adult rats: two beta 1-binding sites for bisoprolol.	1990 Mar	1691366