Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C25H22O10 |
Molecular Weight | 482.4362 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 7 / 7 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CO[C@@]3(O)C(=O)[C@H](C=C([C@H]4OC5=CC(O)=CC(O)=C5C(=O)[C@@H]4O)[C@@]13[H])[C@@H]2C6=CC(OC)=C(O)C=C6
InChI
InChIKey=CYGIJEJDYJOUAN-JSGXPVSSSA-N
InChI=1S/C25H22O10/c1-33-16-4-9(2-3-14(16)27)18-11-7-12(20-13(18)8-34-25(20,32)24(11)31)23-22(30)21(29)19-15(28)5-10(26)6-17(19)35-23/h2-7,11,13,18,20,22-23,26-28,30,32H,8H2,1H3/t11-,13-,18+,20+,22+,23-,25-/m1/s1
Molecular Formula | C25H22O10 |
Molecular Weight | 482.4362 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 7 / 7 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Silydianin is a flavonolignan from Silymarin, which is the major constituent of milk thistle extract. Silydianin, an active constituent of Silybium marianum, have inhibitory properties against the P2Y12 receptor and block ADP-induced blood platelet activation. Silydianin has antiinflammatory activity, it regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger. Silydianin non-competitively inhibits the lipoxygenase from soybeans in vitro. It also inhibits the formation of prostaglandins in vitro.
Approval Year
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16444663
When polymorphonuclear neutrophils were cultured with 100 uM silydianin for 24 h, caspase-3 was activated. Induction of apoptosis by silydianin was accompanied by a decrease in luminol-enhanced chemiluminescence as well as superoxide radical (O2*-) release in freshly isolated cells and lipid peroxidation in mouse spleen microsomes.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:27:29 GMT 2023
by
admin
on
Fri Dec 15 16:27:29 GMT 2023
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Record UNII |
7P89L7W179
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C2081
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NCI_THESAURUS |
C1745
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admin on Fri Dec 15 16:27:29 GMT 2023 , Edited by admin on Fri Dec 15 16:27:29 GMT 2023
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Code System | Code | Type | Description | ||
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29782-68-1
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SUB10520MIG
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C015505
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CHEMBL2107532
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7P89L7W179
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DTXSID70858696
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1612641
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4106
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11982272
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C152360
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100000083492
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249-848-5
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Related Record | Type | Details | ||
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ACTIVE MOIETY |