Atrimustine [bestrabucil, busramustine, KM 2210, kregan], a conjugate of estradiol and chlorambucil, is a DNA antagonist that was developed by Kureha Corporation (Japan). Atrimustine is an antineoplastic drug that was used for the treatment of breast cancer, non-Hodgkin's lymphoma, as well as Graft-versus-host disease. Side effects of atrimustine in clinical trials included vaginal bleeding and gynecomastia. Atrimustine reached preregistration in Japan for the treatment of cancer, however, its development has been discontinued.

Emiglitate (BAYo1248/ BAY- O-1248) a deoxynojirimycin derivative, is an alpha-glucosidase inhibitor that is a powerful inhibitor of glucose-induced insulin release. It was investigated the effect of prolonged administration of this drug on blood glucose control, insulin requirements and breath hydrogen excretion in patients with insulin-dependent diabetes mellitus. And was obtained, that drug reduced postprandial hyperglycaemia and insulin requirements

Estriol acetate benzoate is a semisynthetic, steroidal estrogen. Estriol benzoate diacetate is reported as an ingredient of Holin in Japan. It is an estrogen receptor agonist.

Xanthine derivative, diisobutylaminobenzoyloxypropyl theophylline (Vestphyllin), is a vasodilator, bronchodilator.

Lappaconitine is an alkaloid isolated from the root of Aconltitum sinomantanum Nakai. It has a strong analgesic activity that does not involve the opioid receptor. It was shown to have class-I antiarrhythmic action and irreversibly blocks cloned human heart (hH1) channels by binding to the site 2 receptor.

Silver benzoate is a water soluble crystalline salt composed of silver and benzoic acid with the formula C7H5AgO2 with marked antimicrobial activity. Silver benzoate can be used in synthesis of silver nanoparticle, and in the synthesis of triphenyltinbenzoate. Silver benzoate along with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD) is an efficient catalytic system for the reaction of carbon dioxide with various ketones.

Amidoflumet is a trifluoromethanesulfonanilide compound with high house dust miticidal activity which was discovered by Sumitomo Chemical, and was registered in Japan in 2004. House dust mites and their products are known to be major household allergens to children and the elderly, and they cause asthma and atopic dermatitis. Amidoflumet shows high lethal activity against common house dust mites.

Bopindolol (4-[benzoyloxy-3-tertbutylaminopropoxy]-2-methylindole hydrogen malonate) is an indole beta-adrenoceptor antagonist bearing a benzoyl ester residue on the beta-carbon atom of the propanolamine side chain. Bopindolol is metabolized by esterase to benzoic acid and an active metabolite, 18-502 [4-(3-t-butylamino-2-hydroxypropoxy)-2-methyl indole], which is further metabolized to 20-785 [4-(3-t-butylaminopropoxy)-2-carboxyl indole]. Bopindolol produces sustained blockade of beta 1- and beta 2-adrenoceptors, has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is used in the treatment of hypertension. In limited trials bopindolol has also successfully reduced symptoms in patients with angina pectoris, anxiety and essential tremor.

Delphinine is a toxic diterpenoid alkaloid from the plants Delphinium (larkspur) and Atragene (a clematis). In ancient times delphinine was used as a treatment of lice. In vivo experiments showed that focal application of delphinine causes cardiac arrhythmias, most likely due to modulation of voltage-gated Na+ channels.